A glassy carbon electrode (GCE), modified with graphene (Gr) films, molecularly imprinted (MIP) o... more A glassy carbon electrode (GCE), modified with graphene (Gr) films, molecularly imprinted (MIP) over-oxidized polypyrrole (OPPy), and electrochemically de posited gold nanoparticles (AuNP) was used for rapid detection of dopamine (DA). The as-prepared electrode (AuNP/Gr/OPPy-MIP/GCE) was characterized by Raman spectroscopy and atomic force microscopy (AFM). Electrochemical determination of DA was conducted via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results showed that the modified electrodes exhibited high electrocatalytic activity towards the oxidation of DA in 0.1 M phosphate buffer solution (pH 6.9). Linear dependency of electrocatalytic oxidation current on DA concentrations was observed from 0.5 μM to 8 μM and detection limit was estimated to be 0.1 μM (S/N = 3). The developed electrode could serve as a viable platform for further studies on in vivo detection of DA.
Basic fibroblast growth factor (bFGF) is a potent neurotrophic and vasoactive peptide. Previous s... more Basic fibroblast growth factor (bFGF) is a potent neurotrophic and vasoactive peptide. Previous studies have shown that intraventricularly-administered bFGF reduces the size of cerebral infarcts following focal ischemia. In the current study, we tested the effects of intravenously-administered bFGF in a model of focal ischemia/reperfusion. The right middle cerebral artery of mature male Wistar rats was occluded by intraluminal suture. After 2 h of occlusion, the suture was removed and intravenous infusion of bFGF in vehicle (45 micrograms/kg/h) or vehicle alone was begun, lasting 3 h. Animals were weighed and evaluated neurologically until sacrifice 7 days after ischemia. The volume of cerebral infarcts was then determined by H and E staining and image analysis. We found a 40% reduction in infarct volume in bFGF- vs. vehicle-treated rats (n = 11 vs. 11, P < 0.05). Reduction in infarct volume was associated with improved neurological outcome and regained body weight in bFGF-treate...
A glassy carbon electrode (GCE), modified with graphene (Gr) films, molecularly imprinted (MIP) o... more A glassy carbon electrode (GCE), modified with graphene (Gr) films, molecularly imprinted (MIP) over-oxidized polypyrrole (OPPy), and electrochemically de posited gold nanoparticles (AuNP) was used for rapid detection of dopamine (DA). The as-prepared electrode (AuNP/Gr/OPPy-MIP/GCE) was characterized by Raman spectroscopy and atomic force microscopy (AFM). Electrochemical determination of DA was conducted via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The results showed that the modified electrodes exhibited high electrocatalytic activity towards the oxidation of DA in 0.1 M phosphate buffer solution (pH 6.9). Linear dependency of electrocatalytic oxidation current on DA concentrations was observed from 0.5 μM to 8 μM and detection limit was estimated to be 0.1 μM (S/N = 3). The developed electrode could serve as a viable platform for further studies on in vivo detection of DA.
Basic fibroblast growth factor (bFGF) is a potent neurotrophic and vasoactive peptide. Previous s... more Basic fibroblast growth factor (bFGF) is a potent neurotrophic and vasoactive peptide. Previous studies have shown that intraventricularly-administered bFGF reduces the size of cerebral infarcts following focal ischemia. In the current study, we tested the effects of intravenously-administered bFGF in a model of focal ischemia/reperfusion. The right middle cerebral artery of mature male Wistar rats was occluded by intraluminal suture. After 2 h of occlusion, the suture was removed and intravenous infusion of bFGF in vehicle (45 micrograms/kg/h) or vehicle alone was begun, lasting 3 h. Animals were weighed and evaluated neurologically until sacrifice 7 days after ischemia. The volume of cerebral infarcts was then determined by H and E staining and image analysis. We found a 40% reduction in infarct volume in bFGF- vs. vehicle-treated rats (n = 11 vs. 11, P < 0.05). Reduction in infarct volume was associated with improved neurological outcome and regained body weight in bFGF-treate...
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