Papers by Dr. Shamama Javed
Journal of Pharmaceutical Innovation, Jun 1, 2011
Objective Ipomoea genus is an excellent source of lysergol which is used as a hypotensive and p... more Objective Ipomoea genus is an excellent source of lysergol which is used as a hypotensive and psychrotopic analgesic. Microwave-assisted extraction (MAE) was employed to extract lysergol from Ipomoea seeds, and response surface methodology (RSM) was applied to predict optimum conditions for extraction. Methodology Box–Behnken statistical design was used to monitor the effect of independent variables like temperature (A—50°C, 60°C, and 70°C),
Journal of Pharmacy and Bioallied Sciences, 2023
Frontiers in Pharmacology, May 19, 2023
Breast cancer being one of the most frequent cancers in women accounts for almost a quarter of al... more Breast cancer being one of the most frequent cancers in women accounts for almost a quarter of all cancer cases. Early and late-stage breast cancer outcomes have improved dramatically, with considerable gains in overall survival rate and disease-free state. However, the current therapy of breast cancer suffers from drug resistance leading to relapse and recurrence of the disease. Also, the currently used synthetic and natural agents have bioavailability issues which limit their use. Recently, nanocarriers-assisted delivery of synthetic and natural anticancer drugs has been introduced to the breast cancer therapy which alienates the limitations associated with the current therapy to a great extent. Significant progress has lately been made in the realm of nanotechnology, which proved to be vital in the fight against drug resistance. Nanotechnology has been successfully applied in the effective and improved therapy of different forms of breast cancer including invasive, non-invasive as well as triple negative breast cancer (TNBC), etc. This review presents a comprehensive overview of various nanoformulations prepared for the improved delivery of synthetic and natural anticancer drugs alone or in combination showing better efficacy and pharmacokinetics. In addition to this, various ongoing and completed clinical studies and patents granted on nanotechnology-based breast cancer drug delivery are also reviewed.
Molecules, Jul 16, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Dissolution Technologies
Rosuvastatin (RST), a BCS class II drug, is a poorly water-soluble antihyperlipidemic agent. The ... more Rosuvastatin (RST), a BCS class II drug, is a poorly water-soluble antihyperlipidemic agent. The aim of the present work was to determine and compare the drug release kinetics from the RST calcium innovator (Crestor) and generic products (Ivarin and Resova) marketed in Saudi Arabia by employing various drug release kinetic mathematical models. A dissolution study was performed on all RST calcium immediate-release tablets. The in vitro drug release profiles were determined in three different dissolution media: 0.1 N HCl (pH 1.2), 0.05 M phosphate buffer (pH 6.8), and 0.05 M citrate buffer (pH 6.6). Drug release data were obtained, correlated quantitatively, and interpreted with the help of mathematical models, then the drug release kinetics were analyzed. The criterion for selecting the most suitable model was based on the highest coefficient of correlation (R 2) with the dissolution profile in each respective media. The innovator product followed the Hixson-Crowell model (R 2 = 0.955) only in 0.1 N HCl (pH 1.2), whereas in other media all the formulations followed first order release kinetics with non-swellable matrix Fickian diffusion, which is considered ideal for an immediate-release tablet formulation.
Pharmaceutics
Background: Quercetin (QCT) is a natural polyphenolic flavonoid showing great potential in the tr... more Background: Quercetin (QCT) is a natural polyphenolic flavonoid showing great potential in the treatment of skin cancer. However, its use is limited owing to its poor water solubility, poor absorption, quick metabolism and excretion, as well as low stability. Preparation of nanoemulgel has been proven to be an effective approach to deliver the drugs topically due to various advantages associated with it. Objectives: This study aimed to prepare stable nanoemulgel of QCT using a Design-of-Experiments (DoE) tool for optimization, to characterize and to assess its in vivo toxicity and efficacy against human cancer cell lines in vitro. Methods: An ultrasonication emulsification method was used for the preparation of QCT-loaded nanoemulsion (QCT@NE). Box–Behnken design was used for the optimization of developed nanoemulgel. Then, in vitro characterization of prepared nanoemulsion was performed using Fourier Transform-Infra Red (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM), part...
Food & Function
The utilization of plant-derived supplements for disease prevention and treatment has long been r... more The utilization of plant-derived supplements for disease prevention and treatment has long been recognized for their remarkable potential. Ananas comosus, commonly known as pineapple, produces a group of enzymes called...
Biomedicines, Apr 7, 2023
Nanotechnology Reviews
The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid lipid nan... more The lipid-based colloidal carriers, such as nanostructured lipid carriers (NLCs), solid lipid nanoparticles (SLNs), nanocapsules, liposomes, and microemulsion, are the latest and significant entrants in the development of drug delivery systems owing to their myriad advantages. The NLCs are second-generation SLNs having unstructured matrix, have high drug loading, and provide long-term drug stability in comparison to SLNs and other colloidal systems, which show lower drug loading and experience burst release/drug expulsion during storage. This review is aimed to summarize the formulation development and optimization strategies for NLCs as reported in the literature collected from authentic databases. Various types of NLCs, formulation components, methods of preparation, characterization parameters, optimization (statistical designs) strategies, toxicity, regulatory aspects, and their applications in oral, parenteral, ocular, pulmonary, nose-to-brain, tumor targeting, and transdermal ...
Brazilian Journal of Pharmaceutical Sciences, 2022
Pharmacokinetic studies were carried out in male and female rats to quantify silymarin as silybin... more Pharmacokinetic studies were carried out in male and female rats to quantify silymarin as silybin (A+B) after the oral administration of various silymarin formulations combined with three bioenhancers, namely, lysergol, piperine, and fulvic acid, and compared with plain silymarin formulation (control). A non-compartmental analysis, model independent analysis, was utilized, and various pharmacokinetic parameters (C max , T max , and AUC 0-t) were calculated individually for each treatment group, and the values were expressed as mean ± SEM (n = 6). Plasma samples obtained from the rats were analyzed for the concentration of silymarin through a validated RP-HPLC method and on the basis of data generated from the pharmacokinetic studies. Results indicated that the bioenhancers augmented pharmacokinetic parameters and bioavailability increased 2.4-14.5-fold in all the formulations compared with the control. The current work envisages the development of an industrially viable product that can be further subjected to clinical trials and scientifically supports the development of silymarin as a contemporary therapeutic agent with enhanced bioavailability and medicinal values.
Recent Patents on Anti-Cancer Drug Discovery
Background: Gefitinib, a tyrosine kinase inhibitor, is effectively used in the targeted treatment... more Background: Gefitinib, a tyrosine kinase inhibitor, is effectively used in the targeted treatment of malignant conditions. It suppresses the signal transduction cascades leading to cell proliferation in the tumors and is now currently approved in several countries globally as secondline and third-line treatment for non-small cell lung cancer (NSCLC). Objective: This review is aimed to summarize the journey of gefitinib as an established anticancer drug for the management of various cancers. Moreover, this review will focus on the mechanism of action, established anticancer activities, combination therapy, nanoformulations, as well as recent clinical trials and patents on gefitinib Methods: The data for this review was collected from scientific databases such as PubMed, Science Direct, Google Scholar, etc. Recent patents on gefitinib granted in the last two years were collected from databases Patentscope, USPTO, Espacenet, InPASS and Google Patents. Data for the recent clinical trial...
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, 2013
Microemulsions which are dispersions of an immiscible liquid within another liquid where droplet ... more Microemulsions which are dispersions of an immiscible liquid within another liquid where droplet formation is facilitated by the addition of surfactants and cosurfactants are being extensively used as eluents in microemulsion based high performance liquid chromatography methods to separate, resolve, detect, and quantify solutes within a given sample. Such a novel technique has considerable application in the fields of pharmaceuticals, analytical chemistry, quality control assays, natural products analysis, and non-pharmaceutical analysis as well.
Phytotherapy Research, 2022
Molecules, 2022
The present study aimed to develop a local dental nanoemulgel formulation of Nigella sativa oil (... more The present study aimed to develop a local dental nanoemulgel formulation of Nigella sativa oil (NSO) for the treatment of periodontal diseases. NSO purchased from a local market was characterized using a GC–MS technique. A nanoemulsion containing NSO was prepared and incorporated into a methylcellulose gel base to develop the nanoemulgel formulation. The developed formulation was optimized using a Box–Behnken statistical design (quadratic model) with 17 runs. The effects of independent factors, such as water, oil, and polymer concentrations, were studied on two dependent responses, pH and viscosity. The optimized formulation was further evaluated for droplet size, drug release, stability, and antimicrobial efficacy. The developed formulation had a pH of 7.37, viscosity of 2343 cp, and droplet size of 342 ± 36.6 nm. Sustained release of the drug from the gel for up to 8 h was observed, which followed Higuchi release kinetics with non-Fickian diffusion. The developed nanoemulgel form...
Objective: In the present study Foam Granulation Technique (FGT) TM was employed in the developme... more Objective: In the present study Foam Granulation Technique (FGT) TM was employed in the development of IR tablets of high dose of silymarin dried plant extract which is a very fine, poorly compressible material with poor water solubility and these characteristic features poses extensive technological challenge in its manufacturing. Methods: In FGT, the Methocel E6 PLV was used as foam binder in varying concentrations of 1%, 5%, 7% and 10%. The evaluation of potentially important foam properties, foam penetration mechanism assessment and tablet evaluation was carried out in details and compared with direct compression tablet of silymarin. Results and Discussion: The foam penetration followed foam drainage controlled mechanism and was found to be less dependent on the powder hydrophobicity compared to water drop which followed drop controlled mechanism. The foam induced nucleation successfully created nuclei with relatively uniform structure, size and sphericity as compared to water. The dissolution profile of silymarin foam bonded tablets with 5% Methocel E6 exhibited better dissolution profiles with T 20%, T 50%, T 75% at 6, 30 and 120 min, when compared with direct compression control tablets with T 20% at 120 min. The drug release from optimized 5% foam tablets followed Higuchi model with R 2 = 0.8831 and were found to be stable in accelerated stability studies for a period of 3 months. Conclusion: Thus silymarin with high dose-low solubility characteristics can be easily formulated into IR tablet for clinical and commercial use using this helpful technique.
Pharmaceutics, 2021
Recently, drug delivery using natural biological carriers has emerged as one of the most widely i... more Recently, drug delivery using natural biological carriers has emerged as one of the most widely investigated topics of research. Erythrocytes, or red blood cells, can act as potential carriers for a wide variety of drugs, including anticancer, antibacterial, antiviral, and anti-inflammatory, along with various proteins, peptides, enzymes, and other macromolecules. The red blood cell-based nanocarrier systems, also called nanoerythrosomes, are nanovesicles poised with extraordinary features such as long blood circulation times, the ability to escape immune system, the ability to release the drug gradually, the protection of drugs from various endogenous factors, targeted and specified delivery of drugs, as well as possessing both therapeutic and diagnostic applications in various fields of biomedical sciences. Their journey over the last two decades is escalating with fast pace, ranging from in vivo to preclinical and clinical studies by encapsulating a number of drugs into these car...
Critical Reviews™ in Therapeutic Drug Carrier Systems, 2020
Carbon nanotubes (CNTs) have been identified as one of the most advanced and versatile nanovector... more Carbon nanotubes (CNTs) have been identified as one of the most advanced and versatile nanovectors, theranostics, and futuristic drug delivery tools for highly effective delivery of genes, drugs, and biomolecules, as well as for use in bioimaging and as biosensors. CNTs have drawn tremendous attention and interest from researchers worldwide in the past two decades owing to a number of unique characteristics including well defined physicochemical properties, large surface area, in addition to exclusive electrical and optical properties. Numerous recent literature related to the design and applications of CNTs were studied and summarized accordingly. Special emphasis was given for the applications of CNTs in drug targeting. Specific targeting of anticancer drugs such as cisplatin, doxorubicin, taxol, gemcitabine, and methotrexate, and delivery of small interfering RNA, micro-RNA, as well as plasmid DNA have been successfully assisted using CNTs. All the major applications of CNTs were summarized in detail with possible toxicity concerns associated with them. As far as their toxicity is concerned, it was noticed that the functionalized CNTs pose little toxicity and do not have immunogenic effects. In conclusion, CNTs showed great potential in developing a new generation of carriers for various drugs and related biomolecules. The application of CNTs ranges from physics to chemistry and now they are expanding their roles in the therapeutic drug delivery in the modern healthcare system. With applications in every imaginable route of administration, CNTs bring therapeutic benefits to society. The pharmaceutical, biopharmaceutical, pharmacokinetic, pharmacodynamic, and clinical efficacy of CNTs is explored in detail in this review.
Journal of Liquid Chromatography & Related Technologies, 2019
Abstract Microemulsion Liquid Chromatography (MELC) and Microemulsion Electrokinetic Chromatograp... more Abstract Microemulsion Liquid Chromatography (MELC) and Microemulsion Electrokinetic Chromatography (MEEKC) respectively have emerged as new forms of analytical techniques for the separation of drugs of different water solubilities, solving different separation challenges and offer a variety of applications in pharmaceutical industry and routine quality control analysis of drugs. A comprehensive review of the literatures on recent developments in the field of Microemulsion based techniques was made. Various literatures dealing with microemulsion based chromatographic techniques were collected and studied extensively. Major findings of all the important literatures were summarized and classified in an appropriate manner to help reader understand the types, methods and applications of the technique. This article covers basic concepts of microemulsion, their optimization parameters, advantages and disadvantages and a plethora of applications and research done over the last decade. Almost all the major researches done in the field were tried to cover. Microemulsion based chromatographic techniques have been proved to be a newer and interesting technique that is extensively studied nowadays. Due to their polyphasic structure, microemulsion as eluent in both MELC and MEEKC offers a large number of advantages, applications and capability in separating the mixture of components. Graphical Abstract
Recent Patents on Drug Delivery & Formulation, 2010
Coenzyme Q10 (CoQ10) is a major antioxidant principle found in human body which plays a vital rol... more Coenzyme Q10 (CoQ10) is a major antioxidant principle found in human body which plays a vital role in maintaining several biochemical pathways of body. It acts as a potential mediator in transferring electrons in oxidoreductive reactions of electron transport chain. Chemically, it is a basic quinone containing moiety having a large and high molecular weight structure. Deficiency of this in body leads to several potential disorders like dysfunctions in cellular energetics, neurological degeneration, higher oxidative stress induced damage, breast cancer etc. The high molecular weight and lipophilicity of CoQ10 makes it poorly water soluble and consequently leads to low systemic availability. Several advancements have been made to enhance the bioavailability of CoQ10 using various approaches like size reduction, solubility enhancement (by solid dispersion, prodrug, complexation, ionization) and use of novel drug carriers such as liposomes, microspheres, nanoparticles, nanoemulsions and self-emulsifying system. The primary objective of the present review is to assemble patents representing the various approaches used for enhancement of CoQ10 bioavailability.
Acta Poloniae Pharmaceutica - Drug Research
This study was aimed to prepare, optimize and characterize cost-effective and mucoadhesive dental... more This study was aimed to prepare, optimize and characterize cost-effective and mucoadhesive dental minocycline microspheres for the treatment of periodontitis. There is a need and scope for a costeffective novel formulation of minocycline for periodontitis that can be delivered to the base of the pockets and is biodegradable, bioadhesive, and non-toxic. The Central composite design (CCD) was utilized to study the effects of process variables (5 levels) on the responses including size (R1), drug-entrapment (R2), mucoadhesion (R3), and percent in-vitro drug release (R4). Chitosan-minocycline microspheres were prepared by W/O emulsion technique using glutaraldehyde and sodium tripolyphosphate as different cross-linking agents. Results indicated that the concentration of polymer, drug, cross-linking agent, and cross-linking method significantly affected drug incorporation efficiencies and microsphere characteristics. The minocycline release from the microspheres provided a retarded release up to 8 h and all concentrations were observed to be more than the minimum inhibitory concentration (MIC) required for inhibiting the growth of Staphylococcus aureus. The study concluded that the microspherical system provides advantages over systemic drug administration, including reduction of systemic side effects and dramatic increase in sustained drug concentrations in the gingival cervicular fluid. Local delivery by means of microspheres has several advantages over systemic drug intake including lesser systemic side effects, reduction of dose, mucoadhesiveness, and cost-effectiveness.
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Papers by Dr. Shamama Javed