Papers by Eva Wiberg-itzel
BMC Pregnancy and Childbirth, May 4, 2021
BMC Pregnancy and Childbirth, Mar 8, 2023
Bjog: An International Journal Of Obstetrics And Gynaecology, Dec 12, 2008
To assess whether lactate determination in vaginal fluid is associated with and can predict onset... more To assess whether lactate determination in vaginal fluid is associated with and can predict onset of labour for women with suspected preterm prelabour rupture of membranes (PPROMs). Prospective observational study. Labour ward at South General Hospital, Stockholm, Sweden. POPULATION/PARTICIPANTS: Women with suspected PPROMs at 20-36 completed weeks of gestation (n = 81). All women underwent a speculum examination and a test for determining lactate concentration in vaginal fluid. We used logistic regression to estimate the association between lactate concentration in vaginal fluid and time to onset of labour. Time from examination to spontaneous onset of labour (cervix > or =4 cm). The median time between examination and onset of labour was 13.6 hours for those with a high (> or =4.5 mmol/l) lactate concentration and 1152 hours (i.e. 48 days) for those with a low (<4.5 mmol/l) lactate concentration. For a lactate threshold of 4.5 mmol/l, the likelihood ratio for positive test (LR+) was 12.6, and LR- was 0.14 for the outcome of spontaneous onset of labour within 48 hours. A high lactate concentration in vaginal fluid is strongly associated with whether a woman with suspected PPROM will commence onset of labour within 48 hours. If confirmed, use of lactate ('LAC test') as a predictive test for onset of preterm labour may be an attractive tool in bedside obstetrics.
Acta Obstetricia et Gynecologica Scandinavica, 2008
Journal of Maternal-fetal & Neonatal Medicine, Dec 1, 2020
American Journal of Obstetrics and Gynecology, 2014
Journal of Maternal-fetal & Neonatal Medicine, Nov 10, 2021
PURPOSE OF THIS REVIEW Even today, hundreds of thousands of women die or suffer high levels of mo... more PURPOSE OF THIS REVIEW Even today, hundreds of thousands of women die or suffer high levels of morbidity associated with childbirth. One of the most common causes is halted labor progress, or labor dystocia. There have been no developments in the diagnosis or treatment of dystocic deliveries since Friedman designed the Partogram in the 1950s. Oxytocin is the only treatment for dystocic labor. Sometimes, oxytocin is a lifesaver for the woman, especially in severe postpartum hemorrhages. At the same time, it is also one of the most overused drugs in obstetric care. This review article is meant to provide a short overview of the current knowledge of uterine metabolism during labor, uterine lactate production, and its association with labor dystocia. The article also intends to reflect new ways of thinking regarding practical recommendations for treating labor dystocia and offer a look at the future of dystocic labor management.
BioMed Research International, 2017
Open Journal of Obstetrics and Gynecology, 2021
Journal of Maternal-fetal & Neonatal Medicine, Jun 22, 2017
Human Reproduction, Jun 1, 2023
Bjog: An International Journal Of Obstetrics And Gynaecology, May 15, 2019
Acta Obstetricia et Gynecologica Scandinavica, Mar 12, 2020
Journal of Perinatal Medicine, Aug 28, 2018
Lactic acid dehydrogenase (LDH) is a valuable marker for some of the most important diseases in n... more Lactic acid dehydrogenase (LDH) is a valuable marker for some of the most important diseases in newborns and the plasma LDH activity in newborns correlates well with conditions such as asphyxia. If LDH should be considered as a useful tool also in obstetric care, key factors associated with maternal health before and during pregnancy which could affect umbilical cord LDH activity need to be known. The aims of this study were to explore relationships between selected maternal conditions and arterial lactic acid dehydrogenase activity (aLDH) in umbilical cord blood at delivery. A prospective observational study was conducted at Sodersjukhuset, Stockholm, Sweden. Included in the study were 1247 deliveries, and cord blood samples from each were analyzed for aLDH. Background, delivery and neonatal data were collected from the medical records. Higher median values of aLDH were found (P=0.001) among women with chronic disorders not related to pregnancy but there was no increased frequency of high aLDH levels (>612 μ/L, P=0.30). No difference in aLDH was identified between infants born to women with pregnancy-related disorders compared with healthy women, neither in median values, nor in high values (>612 μ/L, P=0.95). Newborn infants born to women with non-pregnancy-related chronic disorders had a somewhat higher median value of aLDH in cord blood at delivery. The influence of common maternal conditions and diseases on umbilical cord arterial LDH levels is small compared to the increase reported in fetal distress and several other critical conditions in the newborn.
American Journal of Hypertension, Aug 16, 2012
BMC Research Notes, Feb 6, 2013
European Journal of Obstetrics & Gynecology and Reproductive Biology, Sep 1, 2010
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Papers by Eva Wiberg-itzel