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First Evidence of Akodon-Borne Orthohantavirus in Northeastern Argentina

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Abstract

Orthohantaviruses (genus Orthohantavirus, family Hantaviridae) are the etiologic agents of Hantavirus Pulmonary Syndrome in the Americas. In South America, orthohantaviruses are highly diverse and are hosted by sigmodontine rodents (subfamiliy Sigmodontinae, family Cricetidae), an also diverse group of rodents. The aims of this work were to (1) identify orthohantavirus hosts and (2) to study the spatial and temporal variations in the prevalence of infection and their associations with community, environmental and individual characteristics, in different environments of Misiones province, northeastern Argentina. Live-capture sessions were carried out during two years in different land uses, with a trapping effort of 31,653 trap nights. We captured 719 individuals from the species Akodon montensis, Rattus rattus, Mus musculus, Calomys tener, Thaptomys nigrita, Oligoryzomys nigripes, Euryoryzomys russatus, Oligoryzomys flavescens, Brucepattersonius sp., and Juliomys pictipes. Antibodies against orthohantavirus were detected in Akodon montensis in one natural protected and one periurban areas, and it was the most abundant species in almost every study sites. We observed the presence of spatial focality of orthohantavirus infection and a positive association with host abundance suggesting the existence of a threshold density. At the individual level, large, reproductively active, and male individuals were more likely to have antibodies against orthohantavirus. This is the first record of orthohantavirus infection in A. montensis in Argentina, which shows the importance of investigations about emerging diseases.

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Acknowledgements

The authors acknowledge Ramon Sosa (INMeT), Nilso Molina (INMeT), Mara Urdapilleta (CONICET-INMeT), Daniela Lamattina (INMeT), Victoria Gnazzo (INMeT), Ariel Lopez (INMeT), Lara Thorton (FCEN-UBA), Cecilia Moreira (Ministry of Health of the Province of Buenos Aires), Lidiane García de Souza (Universidad de Lavras, Minas Gerais, Brazil) and Annika Schlötelburg. (JULIUS KÜHN-INSTITUT, Alemania) for their cooperation with the samplings and Cecilia Lanzone for helping us to confirm the host rodent species. We acknowledge to the neighbors and agricultural farmers for their interest in the project. Also, we are thankful to Administración de Parques Nacionales (Argentinian National Park Service), Ministerio de Ecología y Recursos Naturales Renovables (Misiones Ministry of Renewable Natural Resources), Gobierno de Misiones (Misiones government), and Ejército Argentino (Argentine Army) for granting us permission to work in natural protected areas.

Funding

Financial support was provided by Universidad de Buenos Aires (UBACyT 2018–20-20020170100171BA), CONICET (PIP 2015–17/11220150100536CO), Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (PICT-2018–01652, PICT-2016–1276), INMeT- ANLIS “Dr. Carlos G. Malbrán” and Sociedad Argentina para el Estudio de los Mamíferos (SAREM, fieldwork grant and Reig Graduate Student Award).

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Authors and Affiliations

  1. Instituto Nacional de Medicina Tropical, Administración Nacional de Laboratorios e Institutos de Salud “Dr. Carlos G. Malbrán”. Ambar s/n, Puerto Iguazú, Misiones, Argentina

    E. F. Burgos, M. V. Vadell & O. D. Salomon

  2. Consejo Nacional de Investigaciones Científicas y Técnicas, Godoy Cruz 2290, Ciudad Autónoma de Buenos Aires, Argentina

    E. F. Burgos, M. V. Vadell & O. D. Salomon

  3. Instituto Nacional de Enfermedades Infecciosas Administración Nacional de Laboratorios E Institutos de Salud Dr. Carlos G. Malbrán, Buenos Aires, Argentina

    C. M. Bellomo & V. P. Martinez

  4. Instituto de Ecología, Genética y Evolución de Buenos Aires (CONICET-UBA). Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160 - Ciudad Universitaria, C1428EGA, Ciudad Autónoma de Buenos Aires, Argentina

    I. E. Gómez Villafañe

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  1. E. F. Burgos
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  2. M. V. Vadell
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  3. C. M. Bellomo
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Correspondence to I. E. Gómez Villafañe.

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Burgos, E.F., Vadell, M.V., Bellomo, C.M. et al. First Evidence of Akodon-Borne Orthohantavirus in Northeastern Argentina. EcoHealth 18, 429–439 (2021). https://doi.org/10.1007/s10393-021-01564-6

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