(Q14864755)

https://gemma.msl.ubc.ca/phenotypes.html?phenotypeUrlId=DOID_0014667&ncbiId=4023

http://www.genome.gov/gwastudies/index.cfm?gene=LPL

Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits

Phenocarta

lipid metabolism disorder

25 May 2020

genome-wide association study

TAS

1 reference

https://gemma.msl.ubc.ca/phenotypes.html?phenotypeUrlId=DOID_3146&ncbiId=4023

http://www.genome.gov/gwastudies/index.cfm?gene=LPL

Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis

Phenocarta

familial lipoprotein lipase deficiency

25 May 2020

2 references

13 August 2019

Open Targets Platform

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000175445/MONDO_0009387

based on heuristic

inferred from an Open Targets association score over 0.7

hyperlipoproteinemia, type 1D

1 reference

Open Targets Platform

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000175445/Orphanet_411

based on heuristic

inferred from an Open Targets association score over 0.7

mixed hyperlipidemia

1 reference

Open Targets Platform

24 August 2023

https://platform.opentargets.org/evidence/ENSG00000175445/Orphanet_79211

based on heuristic

inferred from an Open Targets association score over 0.7

chromosome

human chromosome 8

genomic assembly

1 reference

1 reference

19901717

1 reference

19759228

1 reference

19824769

1 reference

19967259

lipoprotein lipase activity

1 reference

8p21.3

1 reference

15 May 2022

8 references

9 May 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Rapid and simple isolation procedure for lipoprotein lipase from human milk

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

phospholipase activity

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

triglyceride lipase activity

ISS

4 references

9 May 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

signaling receptor binding

1 reference

9 May 2017

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

4 references

9 May 2017

Missense mutation (Gly----Glu188) of human lipoprotein lipase imparting functional deficiency

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5

apolipoprotein binding

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

carboxylic ester hydrolase activity

IPI

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

5 references

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Identification and characterization of two novel mutations in the LPL gene causing type I hyperlipoproteinemia

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Rapid and simple isolation procedure for lipoprotein lipase from human milk

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

anchored component of membrane

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

very-low-density lipoprotein particle

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

extracellular exosome

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

retinoid metabolic process

biological process

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

2 references

fatty acid biosynthetic process

3 references

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

triglyceride metabolic process

IC

1 reference

9 May 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

phospholipid metabolic process

ISS

1 reference

9 May 2017

Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

positive regulation of cholesterol storage

ISS

1 reference

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

positive regulation of sequestering of triglyceride

1 reference

9 May 2017

VLDL-induced triglyceride accumulation in human macrophages is mediated by modulation of LPL lipolytic activity in the absence of change in LPL mass

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

triglyceride catabolic process

6 references

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Rapid and simple isolation procedure for lipoprotein lipase from human milk

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Modulation of lipoprotein lipase activity by apolipoproteins. Effect of apolipoprotein C-III

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

9 May 2017

Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

cholesterol homeostasis

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

positive regulation of inflammatory response

1 reference

9 May 2017

MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

regulation of lipoprotein lipase activity

IC

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

low-density lipoprotein particle mediated signaling

TAS

1 reference

9 May 2017

MicroRNA-590 attenuates lipid accumulation and pro-inflammatory cytokine secretion by targeting lipoprotein lipase gene in human THP-1 macrophages

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

Reduction of plasma triglycerides in apolipoprotein C-II transgenic mice overexpressing lipoprotein lipase in muscle

triglyceride homeostasis

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P06858

https://omabrowser.org/oma/vps/P06858/

IGI

HomoloGene ID

200

1 reference

15 May 2022

PBB GE LPL 203549 s at fs.png
732 × 530; 10 KB

0 references

PBB GE LPL 203548 s at fs.png
732 × 530; 10 KB

0 references

2 references

200

2 references

200

https://omabrowser.org/oma/vps/P06858/

1 reference

200

2 references

200

https://omabrowser.org/oma/vps/P06858/

expressed in

olfactory bulb

1

1 reference

7 June 2024

trigeminal ganglion

2

1 reference

7 June 2024

right ventricle

3

1 reference

7 June 2024

spinal ganglia

4

1 reference

7 June 2024

myocardium of left ventricle

5

1 reference

7 June 2024

adipose tissue

6

1 reference

7 June 2024

abdominal fat

7

1 reference

7 June 2024

subcutaneous adipose tissue

8

1 reference

7 June 2024

apex of heart

9

1 reference

7 June 2024

tibial nerve

10

1 reference

7 June 2024

http://identifiers.org/ncbigene/4023

exact match

1 reference

Identifiers.org

http://www.ebi.ac.uk/miriam/main/collections/MIR:00000069

Identifiers

1 reference

15 May 2022

1 reference

15 May 2022

Encyclopædia Britannica Online ID

topic/lipoprotein-lipase

subject named as

lipoprotein lipase

0 references

1 reference

Ensembl transcript ID

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

15 May 2022

1 reference

15 May 2022

1 reference

Online Mendelian Inheritance in Man

19 August 2019

1 reference

inferred by common HGNC mappings on source and on Wikidata

UMLS 2023