(Q14905181)

TGFβ superfamily receptor

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

activin types I and II receptor domain, protein family

1 reference

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

transmembrane receptor protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

protein serine/threonine kinase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

protein serine/threonine/tyrosine kinase activity

1 reference

14 February 2019

Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

protein binding

4 references

14 February 2019

RLP, a novel Ras-like protein, is an immediate-early transforming growth factor-beta (TGF-beta) target gene that negatively regulates transcriptional activity induced by TGF-beta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

growth factor binding

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27040&geneProductId=UniProtKB:P27040

24 April 2018

Regulation of myostatin activity and muscle growth

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27040&geneProductId=UniProtKB:P27040

24 April 2018

Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27040&geneProductId=UniProtKB:P27040

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27040&geneProductId=UniProtKB:P27040

transforming growth factor beta binding

1 reference

14 February 2019

Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

transferase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

inhibin binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

activin binding

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27040&geneProductId=UniProtKB:P27040

24 April 2018

Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27040&geneProductId=UniProtKB:P27040

24 April 2018

Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27040&geneProductId=UniProtKB:P27040

24 April 2018

A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27040&geneProductId=UniProtKB:P27040

transforming growth factor beta-activated receptor activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

transforming growth factor beta receptor activity, type II

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

growth factor binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Regulation of myostatin activity and muscle growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

type I transforming growth factor beta receptor binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

SMAD binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

activin binding

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Isolation and characterization of activin receptor from mouse embryonal carcinoma cells. Identification of its serine/threonine/tyrosine protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

membrane

integral component of plasma membrane

2 references

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

receptor complex

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

activin receptor complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

pattern specification process

biological process

1 reference

24 April 2018

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?protein=P27040&geneProductId=UniProtKB:P27040

gastrulation with mouth forming second

1 reference

14 February 2019

The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

transmembrane receptor protein serine/threonine kinase signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

lymphangiogenesis

1 reference

14 February 2019

ALK1 signaling regulates early postnatal lymphatic vessel development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

anterior/posterior pattern specification

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Generation of activin receptor type IIB isoform-specific hypomorphic alleles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Generation of activin receptor type IIB isoform-specific hypomorphic alleles

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

mesoderm development

1 reference

14 February 2019

The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

artery development

1 reference

14 February 2019

ALK1 signaling regulates early postnatal lymphatic vessel development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

pancreas development

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

determination of left/right symmetry

blood vessel remodeling

1 reference

14 February 2019

ALK1 signaling regulates early postnatal lymphatic vessel development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

regulation of signal transduction

1 reference

14 February 2019

Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

kidney development

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

skeletal system development

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

heart development

The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

activation of protein kinase activity

1 reference

14 February 2019

Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

organ growth

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

insulin secretion

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

response to glucose

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

lung development

1 reference

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

skeletal system morphogenesis

retina vasculature development in camera-type eye

1 reference

14 February 2019

ALK1 signaling regulates early postnatal lymphatic vessel development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

post-embryonic development

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

1 reference

14 February 2019

venous blood vessel development

1 reference

14 February 2019

ALK1 signaling regulates early postnatal lymphatic vessel development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

roof of mouth development

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

odontogenesis of dentin-containing tooth

Regulation of muscle growth by multiple ligands signaling through activin type II receptors

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Regulation of muscle growth by multiple ligands signaling through activin type II receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

embryonic foregut morphogenesis

1 reference

14 February 2019

Activin receptor patterning of foregut organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

lymphatic endothelial cell differentiation

1 reference

14 February 2019

ALK1 signaling regulates early postnatal lymphatic vessel development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

transforming growth factor beta receptor signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

pattern specification process

activin receptor signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

negative regulation of cold-induced thermogenesis

1 reference

14 February 2019

Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27040

serine/threonine-protein kinase, active site

has part(s)

1 reference

activin types I and II receptor domain

1 reference

protein kinase domain

1 reference