(Q28280601)

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Smads and early developmental signaling by the TGFbeta superfamily

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title

Smads and early developmental signaling by the TGFbeta superfamily (English)

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author name string

M Whitman

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1

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language of work or name

English

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publication date

15 August 1998

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published in

Genes & Development

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volume

12

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issue

16

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page(s)

2445-62

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cites work

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The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

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Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium

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The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A human Mad protein acting as a BMP-regulated transcriptional activator

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https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin.

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

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https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Processed Vg1 protein is an axial mesoderm inducer in Xenopus

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Diversity and pattern in the developing spinal cord

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Expression of Smad1 and Smad2 during embryogenesis suggests a role in organ development.

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Progressive determination during formation of the anteroposterior axis in Xenopus laevis.

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Expression of activin mRNA during early development in Xenopus laevis

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Mix.1, a homeobox mRNA inducible by mesoderm inducers, is expressed mostly in the presumptive endodermal cells of Xenopus embryos

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Role of TAK1 and TAB1 in BMP signaling in early Xenopus development

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5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TGF-beta signalling from cell membrane to nucleus through SMAD proteins

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad5 induces ventral fates in Xenopus embryo

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Immunodetection of Xenopus bone morphogenetic protein-4 in early embryos.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Mads and Smads in TGF beta signalling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Daughters against dpp modulates dpp organizing activity in Drosophila wing development

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Human Smad3 and Smad4 are sequence-specific transcription activators

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

From mouse to frogs: identification and functional analyses of genes required for induction and patterning of the mesoderm

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Betaglycan presents ligand to the TGF beta signaling receptor.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Ca2+ signaling and intracellular Ca2+ binding proteins

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta).

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Identification of a potential regulator of early transcriptional responses to mesoderm inducers in the frog embryo.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A transcriptional partner for MAD proteins in TGF-beta signalling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Graded changes in dose of a Xenopus activin A homologue elicit stepwise transitions in embryonic cell fate

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Characterization of functional domains within Smad4/DPC4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Conservation of dorsal-ventral patterning in arthropods and chordates.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Nomenclature: vertebrate mediators of TGFbeta family signals

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Localized BMP-4 mediates dorsal/ventral patterning in the early Xenopus embryo.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A structural basis for mutational inactivation of the tumour suppressor Smad4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Morphogens and pattern formation

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Regulation of epidermal induction by BMP2 and BMP7 signaling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TGF-beta signal transduction

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad4 and FAST-1 in the assembly of activin-responsive factor

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad2 role in mesoderm formation, left-right patterning and craniofacial development

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Antagonistic interactions between FGF and BMP signaling pathways: a mechanism for positioning the sites of tooth formation

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad6 inhibits signalling by the TGF-beta superfamily

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Smad proteins physically interact with calmodulin

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Activin signalling and response to a morphogen gradient.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

FGF-4 and BMP-2 have opposite effects on limb growth.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Direct and long-range action of a DPP morphogen gradient.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless.

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Regulation of differentiation by TGF-beta

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

The search for physiological substrates of MAP and SAP kinases in mammalian cells

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Bone morphogenetic proteins in the nervous system

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Molecular cloning and functional analysis of a new activin beta subunit: a dorsal mesoderm-inducing activity in Xenopus

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Formation and function of Spemann's organizer

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

Localization of MAP Kinase Activity in EarlyXenopusEmbryos: Implications for Endogenous FGF Signaling

1 reference

5 June 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.12.16.2445

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DOI

10.1101/GAD.12.16.2445

1 reference

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2170925

OpenCitations bibliographic resource ID

2170925

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2170925

PubMed publication ID

9716398

1 reference

stated in

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2170925

(Q28280601)

Smads and early developmental signaling by the TGFbeta superfamily

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