(Q34536583)

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Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells

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Europe PubMed Central

PubMed publication ID

2 August 2017

Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells (English)

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Europe PubMed Central

PubMed publication ID

2 August 2017

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renal cell carcinoma

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based on heuristic

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author name string

Lakshman Gunaratnam

1

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Europe PubMed Central

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2 August 2017

Melissa Morley

2

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Europe PubMed Central

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2 August 2017

Aleksandra Franovic

3

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Europe PubMed Central

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2 August 2017

Natalie de Paulsen

4

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Europe PubMed Central

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2 August 2017

Karim Mekhail

5

1 reference

Europe PubMed Central

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2 August 2017

Doris A E Parolin

6

1 reference

Europe PubMed Central

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2 August 2017

Eijiro Nakamura

7

1 reference

Europe PubMed Central

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2 August 2017

Ian A J Lorimer

8

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Europe PubMed Central

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2 August 2017

Stephen Lee

9

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2 August 2017

language of work or name

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publication date

27 August 2003

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Europe PubMed Central

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2 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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2 August 2017

278

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Europe PubMed Central

PubMed publication ID

2 August 2017

45

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

44966-44974

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Europe PubMed Central

PubMed publication ID

2 August 2017

Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer

1 reference

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Functions of the von Hippel-Lindau tumour suppressor protein

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Mutation and cancer: statistical study of retinoblastoma

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Genotype-phenotype correlation in von Hippel-Lindau disease: identification of a mutation associated with VHL type 2A

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Tumour suppression by the human von Hippel-Lindau gene product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

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https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis

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21 January 2018

Molecular basis of the VHL hereditary cancer syndrome

1 reference

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The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity

1 reference

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Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

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21 January 2018

Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C

1 reference

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pVHL19 is a biologically active product of the von Hippel-Lindau gene arising from internal translation initiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

1 reference

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21 January 2018

The Hallmarks of Cancer

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G1 events and regulation of cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Autocrine growth factors and cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Production and characterization of human 293 cell lines expressing the site-specific recombinase Cre.

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Transformation of rat cells by DNA of human adenovirus 5

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A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

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Tranilast inhibits protein kinase C-dependent signalling pathway linked to angiogenic activities and gene expression of retinal microcapillary endothelial cells

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Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

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Human transforming growth factors induce tyrosine phosphorylation of EGF receptors.

1 reference

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EGF receptor ligands

1 reference

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TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase

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21 January 2018

Germline mutations in the vhl gene in patients presenting with phaeochromocytomas

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

The von Hippel-Lindau tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Cancer-susceptibility genes. Gatekeepers and caretakers

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21 January 2018

Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305502200

21 January 2018

Transformation of normal rat kidney (NRK) cells by an infectious retrovirus carrying a synthetic rat type alpha transforming growth factor gene

1 reference

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Autocrine secretion and malignant transformation of cells.

1 reference

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In vitro formation and expansion of cysts derived from human renal cortex epithelial cells

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Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle

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Von Hippel‐Lindau Syndrome

1 reference

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Molecular genetic diagnosis of von Hippel-Lindau disease in familial phaeochromocytoma

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Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas

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The pVHL-associated SCF ubiquitin ligase complex: molecular genetic analysis of elongin B and C, Rbx1 and HIF-1alpha in renal cell carcinoma

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M305502200

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 August 2017

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