Yuhan Chen

Accademia di Belle Arti di Brera, Visual Art, Undergraduate

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Sophie is a freelance writer, and producer, designer . With a BA in English art Literature and MA in visual Art
Supervisors: designer and producer

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WENQING GE

Chung Ang University

Diego Noble

Universidade Federal do Rio Grande do Sul

George Vafiadis

National Technical University of Athens

Mohammad Reza Hosseiny Fatemi

Imam Reza International University

Svetislav Momcilovic

INESC-ID

Leonel Sousa

INESC-ID, IST, Universidade de Lisboa

Julien Dubois

Université de Bourgogne

Vivek Guntumadugu

Raju Rathod

Ze Chen

Hogeschool van Rotterdam

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Papers by Yuhan Chen

2.8 to 67.2mW Low-Power and Power-Aware H.264 Encoder for Mobile Applications

2007 IEEE Symposium on VLSI Circuits, 2007

SWLMs, and then shifted and reused in SRA. 87.5% A 2.8 to 67.2mW H.264 encoder is implemented on ... more SWLMs, and then shifted and reused in SRA. 87.5% A 2.8 to 67.2mW H.264 encoder is implemented on a memory power of IME is thus saved. 12.8mM2 die with 0.1I8 tm CMOS technology. The proposed shows the proposed fractional-pixel ME (FME) parallel architectures along with fast algorithms and data engine. Different from the sequential half-then-quarter reuse schemes enable 77.9% power savings. The power refinement algorithm, the proposed one-pass algorithm awareness is provided through a flexible system hierarchy searches 25 half-pixel/quarter-pixel candidates around the that supports content-aware algorithms and module-wise best integer-pixel candidate to facilitate parallel processing gated clock. and DR. In the proposed parallel architecture, 25 processing

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HFE: An Iron Uptake Regulation Molecule

The Faseb Journal, Apr 1, 2010

Rayon-based activated carbon fibers treated with both alkali metal salt and Lewis acid

Microporous and Mesoporous Materials, 2008

Rayon precursors marinated by mixture aqueous solution containing NaCl and H 3 PO 4 are activated... more Rayon precursors marinated by mixture aqueous solution containing NaCl and H 3 PO 4 are activated by steam for manufacture of activated carbon fibers (ACF) in this work. It is interesting to find that mesopores (2 nm < pore size < 50 nm) and even macropores (pore size > 50 nm) are greatly developed on ACF surface, which indicates that NaCl + H 3 PO 4 aqueous solution is an effectual pore sizeenlarging impregnant. The influences of the concentrations of NaCl and H 3 PO 4 on the pore distribution and morphology of the resulting ACFs are respectively examined by scanning electron microscopy (SEM), revealing that the pore structure can be controlled through an appropriate ratio of NaCl and H 3 PO 4 impregnation. As it has been demonstrated that the adsorptivity of the ACF is related to the fractal characteristics of the pore structure, the fractal structure of the meso/macropores in the ACF is analyzed by the small angle X-ray scattering (SAXS) method, providing the characteristics of volume, size distribution and fractal dimension (D) of the pores, Finally BET analysis has confirmed that ACFs with abundant mesopores/macropores indeed exhibit highly effective adsorption capacity.

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Activation of the JNK-c-Jun pathway in response to irradiation facilitates Fas ligand secretion in hepatoma cells and increases hepatocyte injury

Journal of Experimental & Clinical Cancer Research, 2016

It is well established that some irradiated liver non-parenchymal cells secrete pro-inflammatory ... more It is well established that some irradiated liver non-parenchymal cells secrete pro-inflammatory cytokines to facilitate the development of radiation-induced liver disease. However, little is known on whether the irradiated hepatoma cells-mediated non-irradiated hepatocyte injury occurs in HCC patients. Here, we elucidated the roles of the irradiated hepatoma cells in driving non-irradiated hepatocyte injury and its underlying mechanism. SMMC7721 cells were cultured and divided into irradiated (4-Gy X-ray, R) and non-irradiated (NR) groups. At 24th hour after irradiation, conditioned medium (CM) from these cultures was mixed with normal culture medium in specific proportions, and termed as 7721-R-CM and 7721-NR-CM. Following incubation with these CM compound, the biological characteristics of L02 cells related to liver cell injury including viability, apoptosis and liver dysfunction indices were comparatively analyzed. Simultaneously, the levels of proliferation- and apoptosis-related cytokines in irradiated and non-irradiated SMMC7721 cells were also measured. FasL as a cytokine with significantly differential expression, was selected to clarify its effects on L02 apoptosis. Subsequently, FasL expression following irradiation was examined in SMMC7721 and other HCC cells with varying malignant potentials, as well as in HCC tissues, the related mechanism of higher expression of FasL in irradiated HCC cells was further investigated. Apoptosis and liver dysfunction indices were all significantly enhanced in L02 cells treated with 7721-R-CM, whereas viability was suppressed, compared to those with 7721-NR-CM stimulation. FasL was identified as a leading differential cytokine in the irradiated SMMC7721 cells. Higher proportion of apoptosis was also found in L02 cells following FasL incubation. A recombinant Fas-Fc protein, which blocks Fas-FasL interaction, ameliorated 7721-R-CM-induced apoptosis in L02 cells. FasL was highly expressed in a dose-dependent manner, and peaked at the 24th hour post-irradiation in different HCC cells and their culture supernatant. Meanwhile, phosphorylation levels of JNK, ERK, Akt, and p38 were all upregulated significantly in irradiated HCC cells. But, only JNK inhibition was validated to block radiation-induced FasL expression in HCC cells. c-Jun, the target transcription factor of JNK, was also activated. In HCC cells, the JNK-c-Jun pathway plays an important role in mediating irradiation- induced FasL expression, which may be critical in determining non-irradiated hepatocyte injury.

MicroRNA-146a-5p Negatively Regulates Pro-Inflammatory Cytokine Secretion and Cell Activation in Lipopolysaccharide Stimulated Human Hepatic Stellate Cells through Inhibition of Toll-Like Receptor 4 Signaling Pathways

International Journal of Molecular Sciences, 2016

Lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4) signaling pathway is demonstrated to be invo... more Lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4) signaling pathway is demonstrated to be involved in the hepatic fibrosis. MicroRNA (miR)-146a-5p is a key regulator of the innate immune response. The functional significance of miR-146a-5p during the LPS/TLR4 mediated hepatic fibrosis process remains unclear. In this study, we found that TLR4 and α-smooth muscle actin (α-SMA) were up-regulated and miR-146a-5p was down-regulated in human hepatic stellate cell (HSC) line LX2 after LPS stimulation. Overexpression of miR-146a-5p inhibited LPS induced pro-inflammatory cytokines secretion through down-regulating the expression levels of TLR-4, IL-1 receptor-associated kinase 1 (IRAK1), TNF receptor associated factor-6 (TRAF6) and phosphorylation of nuclear factor-kappa B (NF-κB). Knockdown of IRAK1 and TRAF6 also suppressed pro-inflammatory cytokine production by inhibiting NF-κB phosphorylation. In addition, miR-146a-5p mimic blocked LPS induced TRAF6 dependent c-Jun N-terminal kinase (JNK) and Smad2 activation as well as α-SMA production. Taken together, these results suggest that miR-146a-5p suppresses pro-inflammatory cytokine secretion and cell activation of HSC through inhibition of TLR4/NF-κB and TLR4/TRAF6/JNK pathway.

Clinical Next Generation Sequencing for Precision Medicine in Cancer

Current Genomics, 2015

Rapid adoption of next generation sequencing (NGS) in genomic medicine has been driven by low cos... more Rapid adoption of next generation sequencing (NGS) in genomic medicine has been driven by low cost, high throughput sequencing and rapid advances in our understanding of the genetic bases of human diseases. Today, the NGS method has dominated sequencing space in genomic research, and quickly entered clinical practice. Because unique features of NGS perfectly meet the clinical reality (need to do more with less), the NGS technology is becoming a driving force to realize the dream of precision medicine. This article describes the strengths of NGS, NGS panels used in precision medicine, current applications of NGS in cytology, and its challenges and future directions for routine clinical use.

Study on Design Method of Project Management System Based on Nuclear Power Engineering General Contracting Enterprise

Proceedings of the 18th International Symposium on Advancement of Construction Management and Real Estate, 2014

The analysis of TiO2 doping by different ferric salts

Proceedings of the 2016 International Forum on Energy, Environment and Sustainable Development, 2016

Improvement on Parallel AQPSO Using the Best Position

Proceedings of the 2009 Second International Workshop on Knowledge Discovery and Data Mining, Jan 23, 2009

Propagation characteristics of anisotropic incoherent dipolar beams

Laser Physics, 2003

The effect of calcination temperature on the crystallinity of TiO2 nanopowders

Journal of Crystal Growth, 2003

TiO 2 nanopowders have been prepared using 0.1 M titanium tetraisopropoxide (TTIP) in varied pH a... more TiO 2 nanopowders have been prepared using 0.1 M titanium tetraisopropoxide (TTIP) in varied pH aqueous solution containing TMC and NP-204 surfactants. Only the powder acquired from a solution of pH=2 has a regular particle size distribution. Anatase phase powders are obtained by calcination in nitrogen in the 250-500°C temperature range. When calcined at 400°C, the diameter of the nanoparticles is approximately 10 nm with a specific surface area of 106.9 m 2/g. As the calcination temperature is increased, the particle size increases. Rutile phase powders are formed at calcination temperatures above 600°C.

Light Source Module for Stereoscopic Display, Imaging Device for Stereoscopic Display and Stereoscopic Display System

Position detecting system and method of the same

Methods and Apparatus for Dielectrophoretic Shuttling and Measurement of Single Cells or Other Particles in Microfluidic Chips

High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis

Oncotarget, Apr 13, 2015

Mesothelin is a cell surface glycoprotein which is highly expressed in several epithelial cancers... more Mesothelin is a cell surface glycoprotein which is highly expressed in several epithelial cancers and may have a role in cell adhesion and metastases. In this study, we used prospectively obtained clinical and pathological data to characterize mesothelin expression in advanced lung adenocarcinoma. Tissue was obtained from patients who underwent molecular profiling of potentially actionable genes on a trial of molecular profiling and targeted therapies in advanced thoracic malignancies. We immunohistochemically evaluated the intensity, and the percentage of cells expressing mesothelin in 93 advanced lung adenocarcinomas. The evaluation was blinded for molecular data and outcome. Mutations of EGFR, KRAS, BRAF, AKT1, PIK3CA and HER2 were assessed by pyrosequencing; HER2 amplification and ALK translocation were assessed by fluorescence in situ hybridization. 53% of advanced lung adenocarcinomas expressed mesothelin to some degree; high mesothelin expression, defined as mesothelin positivity in more than 25% of cells, was found in 24% of patients. High mesothelin expression was associated with inferior survival (median 18.2 months vs. 32.9 months; P = 0.014). High mesothelin expression was strongly associated with mutant KRAS (P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.0001) and wild-type EGFR (P = 0.002). Our results provide strong rationale to explore anti-mesothelin targeted therapies in advanced lung adenocarcinoma especially in the KRAS-mutant subgroup.

The chemical structure and genetic locus of Campylobacter jejuni CG8486 (serotype HS:4) capsular polysaccharide: the identification of 6-deoxy-D-ido-heptopyranose

Carbohydrate Research, May 5, 2008

In line with our on-going efforts to create a multivalent anti-Campylobacter jejuni vaccine based... more In line with our on-going efforts to create a multivalent anti-Campylobacter jejuni vaccine based on its capsule polysaccharides (CPSs), we report here the chemical structure and the genetic locus of the CPS produced by C. jejuni strain CG8486, which belongs to the serotype HS:4 CPS complex. C. jejuni CG8486 CPS was observed to be composed of approximately 17 disaccharide repeating blocks of 4-substituted N-acetyl-beta-D-glucopyranosamine and 3-substituted 6-deoxy-beta-D-ido-heptopyranose. A small number of 6-deoxy-beta-D-ido-heptopyranose units were observed to carry O-methyl phosphoramidate moieties at the O-2 or O-7 position. The gene content and organization of the CPS locus of C. jejuni CG8486 were comparable to those of C. jejuni strains NCTC 11168 and 81-176, but several CG8486 CPS genes were observed to be more divergent from those present in the CPS loci of NCTC 11168 and 81-176 CPS, which indicated that there are genetic characteristics specific to the C. jejuni HS:4 CPS complex. The efficacy of a glycoconjugate vaccine based on C. jejuni CG8486 CPS is presently being tested in an animal model, the results of which will be presented in future communications.

Indoor Sound Receiving System and Indoor Sound Receiving Method

Nonparametric Procedures for Simultaneous Identification of the Minimum Effective Dose in Each of Several Groups

Http Dx Doi Org 10 1081 Bip 200025693, Feb 2, 2007

This paper considers the extension of the dose finding problem in a one-way layout setting to the... more This paper considers the extension of the dose finding problem in a one-way layout setting to the case of several groups, in which the main goal is to identify the minimum effective dose (MED) of each group simultaneously. We propose two nonparametric procedures using the respective pairwise- and Helmert-type two-sample Mann-Whitney statistics, which are applied in a step-down testing scheme