Papers by Juan Pablo Quintero
Biomédica, 2012
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Iatreia, Jun 1, 2010
La sepsis, un síndrome de respuesta sistémica a la infección, es un problema de salud pública aso... more La sepsis, un síndrome de respuesta sistémica a la infección, es un problema de salud pública asociado a alta morbilidad y mortalidad alrededor del mundo. Entre los múltiples genes asociados a esta enfermedad se encuentra el gen que codifica para la caspasa12 (csp12), en el ...
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Biomédica, 2012
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Revista Digital Del Instituto Internacional De Costos, 2009
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Med U P B, Jun 1, 2012
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Tdx, 2016
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Colección General, 2012
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IFMBE Proceedings, 2007
Abstract A Van der Pauw electrolytic conductivimeter was development to calibrate an electrical ... more Abstract A Van der Pauw electrolytic conductivimeter was development to calibrate an electrical resistivity probe. This conductivimeter is used in studies of early cancer screen-ing because such studies require a measurement probe, ie, tetra-polar probe, which needs to be ...
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Revista Facultad De Ingenieria Universidad De Antioquia, Jun 1, 2009
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Revista Facultad De Ingenieria Universidad De Antioquia, Jun 1, 2009
ABSTRACT
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Journal of Hazardous Materials, 2014
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Malaria journal, 2015
Malaria transmission in Latin America is typically characterized as hypo-endemic and unstable wit... more Malaria transmission in Latin America is typically characterized as hypo-endemic and unstable with ~170 million inhabitants at risk of malaria infection. Although Colombia has witnessed an important decrease in malaria transmission, the disease remains a public health problem with an estimated ~10 million people currently living in areas with malaria risk and ~61,000 cases reported in 2012. This study aimed to establish the malaria prevalence in three endemic regions of Colombia to aid in designing new interventions for malaria elimination. A cross-sectional survey was conducted in three regions of Colombia with different malaria epidemiological profiles: Tierralta (Ta), Tumaco (Tu) and Buenaventura (Bv). The Annual Parasite Index (API) was 10.7, 6.9 and 3.1, respectively. Participants were asked to respond to a sociodemographic questionnaire and then were bled to determine the Duffy genotype and the prevalence of malaria infection by microscopy and quantitative real-time PCR (qPCR)...
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Genetics in medicine : official journal of the American College of Medical Genetics, Jan 12, 2015
Purpose:The current curative treatment of Fanconi anemia is hematopoietic stem cell transplantati... more Purpose:The current curative treatment of Fanconi anemia is hematopoietic stem cell transplantation; this treatment has a higher rate of successful outcome when donors are compatible siblings. Therefore some families opt to have a healthy and compatible baby after selecting an embryo using preimplantation genetic diagnosis with human leukocyte antigen (HLA) typing. This study aims to estimate the success rate of this procedure from the family's perspective.Methods:Genetic and embryology data were collected from genetic reports provided by the families.Results:A total of 524 oocytes (14.1 oocytes/cycle) and 299 embryos were generated (8.0 embryos/cycle) after 38 in vitro fertilization cycles. Sixteen embryos were transferred to the uterus because they were non-Fanconi anemia and HLA matched. One baby was born. A younger couple delivered a healthy and HLA-compatible baby after four cycles. Therefore, the success rate per cycle is less than 5% (two babies from 42 trials).Conclusion...
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EMBO molecular medicine, 2014
Gene targeting is progressively becoming a realistic therapeutic alternative in clinics. It is un... more Gene targeting is progressively becoming a realistic therapeutic alternative in clinics. It is unknown, however, whether this technology will be suitable for the treatment of DNA repair deficiency syndromes such as Fanconi anemia (FA), with defects in homology-directed DNA repair. In this study, we used zinc finger nucleases and integrase-defective lentiviral vectors to demonstrate for the first time that FANCA can be efficiently and specifically targeted into the AAVS1 safe harbor locus in fibroblasts from FA-A patients. Strikingly, up to 40% of FA fibroblasts showed gene targeting 42 days after gene editing. Given the low number of hematopoietic precursors in the bone marrow of FA patients, gene-edited FA fibroblasts were then reprogrammed and re-differentiated toward the hematopoietic lineage. Analyses of gene-edited FA-iPSCs confirmed the specific integration of FANCA in the AAVS1 locus in all tested clones. Moreover, the hematopoietic differentiation of these iPSCs efficiently ...
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Papers by Juan Pablo Quintero