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Fail:Dna-SNP.svg

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Ringkasan

Keterangan
English: A Single Nucleotide Polymorphism is a change of a nucleotide at a single base-pair location on DNA. Created using OpenSCAD v2021.01 and Inkscape v1.0.2.
Tarikh
Sumber Karya sendiri
Pengarang David Eccles (Gringer)

Construction process

This file was derived from a 3D model of DNA, converted to SVG and coloured using David Eccles' STL2SVG script:

type=orig; ~/scripts/stl2svg.pl ./DNA_linear_complete_helix1.stl:330 ./DNA_linear_complete_helix2.stl:200 ./DNA_linear_complete_${type}_A.stl:140 ./DNA_linear_complete_${type}_C.stl:250 ./DNA_linear_complete_${type}_G.stl:90 ./DNA_linear_complete_${type}_T.stl:30  > out_${type}.svg
type=mut; ~/scripts/stl2svg.pl ./DNA_linear_complete_helix1.stl:330 ./DNA_linear_complete_helix2.stl:200 ./DNA_linear_complete_${type}_A.stl:140 ./DNA_linear_complete_${type}_C.stl:250 ./DNA_linear_complete_${type}_G.stl:90 ./DNA_linear_complete_${type}_T.stl:30  > out_${type}.svg

The DNA models were then combined and annotated using Inkscape. The DNA backbone for the model is a pentagon extruded over a sine wave using David Eccles' guided path extrude script. The model source file (in OpenSCAD format) is shown below:

use <guided_extrude.scad>;

hl = 100; // helix length
hp = 33.2; // helix pitch [in angstroms]
hr = 10; // helix radius [in angstroms]
bbr = 1.5; // backbone radius

loops = hl / hp;

// random bases
//bases = rands(0, 4, ceil(360 * loops / 34.3),1);

// *GRINGENE* -- TAA GGN MGN ATH AAY GGN GAR AAY GAR TGA
//            -- TAA GGC AGG ATC AAC GGC GAG AAC GAG TGA
// A = 0; G = 1; C = 2; T = 3
// [different from my usual order,
//  to simplify the 3D model logic]
bases = [3,3,3, 1,1,2, 0,1,1, 0,3,2, 0,0,2,
         1,1,2, 1,0,1, 0,0,2, 1,0,1, 3,1,0];

bAng = atan2(sin(120) - sin(0), cos(120) - cos(0));

drawMode = "all";

module lineTo(x1, x2){
  hull(){
    translate(x1) sphere(r=0.25, $fn=5);
    translate(x2) sphere(r=0.25, $fn=5);
  }
}

backbone_profile = [for(th = [0:72:359]) [bbr*cos(th),
                                          bbr*sin(th)*1]];

inc = floor($t * 30);
thf = ($t * 30) - inc;
h1limit = (360 * loops);
h1jump = (360 * loops);


helix_1 = [for(th = [(thf*34.3):(34.3/2):h1jump])
  [hr * cos(th), hr * sin(th), hl * th / (360 * loops)]];

helix_2 = [for(th = [120:(34.3/2):(360 * loops+120)])
  [hr * cos(th), hr * sin(th), hl * (th-120) / (360 * loops)]];

module purine(){
  linear_extrude(height=0.75, center=true){
    // average hydrogen bond length in water: 1.97 A
    // https://en.wikipedia.org/wiki/Hydrogen_bond#Structural_details  
    translate([-0.985,0])
      // scale: average of C-C and C=C bond length
      scale(1.435) translate([-2,0]) rotate(12) rotate(18){
        rotate(-30) translate([1,0]) circle(r=1, $fn=6);
        color("blue")
          rotate(36) translate([-1 / (2*sin(36)),0])
            circle(r=1 / (2*sin(36)), $fn=5);
    }
  }
}

module pyrimidine(){
  linear_extrude(height=0.75, center=true){
    // average hydrogen bond length in water: 1.97 A
    // https://en.wikipedia.org/wiki/Hydrogen_bond#Structural_details  
    translate([-0.985,0])
      scale(1.435) translate([-2, 0]) translate([1,0])
         circle(r=1, $fn=6);
  }
}

$vpt = [0, 0, 0];
//$vpr = [310, 105, 10];
$vpr = [0, 0, 0];

rotate([310, 105, 130]) translate([0,0,-hl/2]) {
  if(drawMode == "all" || drawMode == "helix1") color("lightblue")
    mapExtrude("vertCylinder", backbone_profile, helix_1);
  if(drawMode == "all" || drawMode == "helix2") color("pink")
    mapExtrude("vertCylinder", backbone_profile, helix_2);
  for(thb = [inc:(360 * loops / 34.3 + inc)]) {
    thi = thb-inc;
    th = (thi-thf) * 34.3;
    thisBase = bases[floor(thb%30)];
    doPur = (thisBase < 2);
    // base bond has a -1.2° angle;
    // not quite sure how to implement that
    baseFrac = (doPur ? 0.55 : 0.45);
    baseFInv = 1 - baseFrac;
    translate([0,0,hl * th / (360 * loops)]) rotate([-1.2,0,0]){
      if(drawMode == "all" || drawMode == "helix2") color("pink")
        lineTo([hr * cos(th)*(baseFrac-0.15) +
                hr * cos(th+120) * (baseFrac+0.15),
                hr * sin(th)*(baseFrac-0.15) +
                hr * sin(th+120) * (baseFrac+0.15)],
               [hr * cos(th+120), hr * sin(th+120)]);
      if(th < (h1jump))
        if(drawMode == "all" || drawMode == "helix1") color("lightblue")
          lineTo([hr * cos(th), hr * sin(th)],
                 [hr * cos(th)*(baseFrac+0.15) +
                  hr * cos(th+120) * (baseFrac-0.15),
                  hr * sin(th)*(baseFrac+0.15) +
                  hr * sin(th+120) * (baseFrac-0.15)]);
      if(drawMode == "all" ||
         (drawMode == "A" && thisBase == 0) ||
         (drawMode == "G" && thisBase == 1) ||
         (drawMode == "C" && thisBase == 2) ||
         (drawMode == "T" && thisBase == 3)
        )
      color((thisBase < 1) ? "green" : 
            (thisBase < 2) ? "gold"  :
            (thisBase < 3) ? "blue"  :
                             "red")
      translate([hr * cos(th)*baseFrac + hr * cos(th+120) * baseFInv,
                 hr * sin(th)*baseFrac + hr * sin(th+120) * baseFInv])
         rotate(180 + bAng + th) if(doPur) {
            purine(); } else { pyrimidine(); };
      if(drawMode == "all" ||
         (drawMode == "A" && thisBase == 3) ||
         (drawMode == "G" && thisBase == 2) ||
         (drawMode == "C" && thisBase == 1) ||
         (drawMode == "T" && thisBase == 0)
        )
        if(th < (h1jump))
        color((thisBase < 1) ? "red"  : 
              (thisBase < 2) ? "blue" :
              (thisBase < 3) ? "gold" :
                               "green")
        translate([hr * cos(th)*baseFrac + hr * cos(th+120) * baseFInv,
                   hr * sin(th)*baseFrac + hr * sin(th+120) * baseFInv])
           rotate(bAng+th) if(doPur) {
              pyrimidine(); } else { purine(); };
    }
  }
  if(drawMode == "all" || drawMode == "helix1") color("lightblue") {
    translate(helix_1[len(helix_1)-1]) sphere(r=bbr, $fn=5);
    translate(helix_1[0]) sphere(r=bbr, $fn=5);
  }
  if(drawMode == "all" || drawMode == "helix2") color("pink") {
    translate(helix_2[0]) sphere(r=bbr, $fn=5);
    translate(helix_2[len(helix_2)-1]) sphere(r=bbr, $fn=5);
  }
}

Perlesenan

Dengan ini, saya selaku pemegang hak cipta karya ini, menerbitkannya di bawah lesen-lesen yang berikut:
GNU head Kebenaran diberikan untuk menyalin, mengedar dan/atau mengubah dokumen ini di bawah syarat-syarat Lesen Pendokumenan Bebas GNU, versi 1.2 atau mana-mana versi selepas ini, yang diterbitkan oleh Yayasan Perisian Bebas; tanpa Seksyen yang Tak Berubah, tanpa Teks Kulit Depan dan tanpa Teks Kulit Belakang. Salinan lesen ini boleh didapati dalam seksyen yang bertajuk Lesen Pendokumenan Bebas GNU".
w:ms:Creative Commons
pengiktirafan
Fail ini dilesenkan di bawah lesen Pengiktirafan 4.0 Antarabangsa Creative Commons.
Pengiktirafan: SNP model by David Eccles (gringer)
Anda bebas:
  • untuk berkongsi – untuk menyalin, mengedar dan memindah hasil kerja
  • untuk mencampur semula – untuk menyesuaikan karya
Di bawah syarat berikut:
  • pengiktirafan – Anda mesti memberi penghargaan yang berpatutan, bekalkan pautan ke lesen, dan tunjukkan jika perubahan telah dibuat. Anda boleh lakukannya dalam sebarang cara yang munasabah, tetapi bukan dalam sebarang cara yang mencadangkan pemberi lesen mengendors anda atau penggunaan anda.
Anda boleh memilih mana-mana lesen yang anda mahukan.

Captions

Add a one-line explanation of what this file represents
DNA sequence variation in a population. A SNP is just a single nucleotide difference in the genome. The upper DNA molecule differs from the lower DNA molecule at a single base-pair location (a G/A polymorphism)

Items portrayed in this file

menggambarkan

18 Disember 2014

media type Inggeris

image/svg+xml

1,203,312 bait

333 piksel

520 piksel

80e2618911371d2da8252d8edc5d36cf8c929c94

Sejarah fail

Klik pada tarikh/waktu untuk melihat rupa fail tersebut pada waktu itu.

Tarikh/WaktuGambar kenitUkuranPenggunaKomen
semasa13:07, 8 Mei 2021Gambar kenit bagi versi pada 13:07, 8 Mei 2021520 × 333 (1.15 MB)GringerUpdate to slightly more accurate 3D model, showing base rings
21:50, 17 Disember 2014Gambar kenit bagi versi pada 21:50, 17 Disember 2014457 × 298 (251 KB)GringerIncrease nominal size to something readable
21:46, 17 Disember 2014Gambar kenit bagi versi pada 21:46, 17 Disember 2014120 × 80 (244 KB)GringerUpdated to 3D model, different DNA sequence
01:40, 6 Julai 2007Gambar kenit bagi versi pada 01:40, 6 Julai 2007416 × 521 (59 KB)Gringer{{Information |Description=A Single Nucleotide Polymorphism is a change of a nucleotide at a single base-pair location on DNA. Created using Inkscape v0.45.1. [modified to remove long tails on DNA] |Source=self-made |Date=2007-07-06 |Author=David Hall (~~
00:56, 6 Julai 2007Gambar kenit bagi versi pada 00:56, 6 Julai 2007471 × 521 (59 KB)Gringer{{Information |Description=A Single Nucleotide Polymorphism is a change of a nucleotide at a single base-pair location on DNA. Created using Inkscape v0.45.1. |Source=self-made |Date=2007-07-06 |Author=David Hall (~~~) |other_versions= }}

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