Prolonged, sustained or extended release systems, release the active ingredient slowly than conve... more Prolonged, sustained or extended release systems, release the active ingredient slowly than conventional dosage forms similarly administered. Tamsulosin is a selective, potent and competitive α 1 -adrenoreceptor antagonist. It has a greater affinity for the α 1A -receptor subtype and is indicated to treat uretheral stone symptoms associated with benign prostatic hyperplasia. In the present work, attempt was made to develop an once daily sustained release matrix tablet of Tamsulosin hydrochloride. Hydroxy propyl methyl cellulose was used as a hydrophilic matrix polymer. The formulation showed acceptable pharmacotechnical properties and HPLC assay requirements. The present work also involves application of Higuchi's equation, Drug release kinetics, Korsmeyer's and Hixsen-crowell plots. In vitro drug release studies indicated a sustained release pattern.
Prolonged, sustained or extended release systems, release the active ingredient slowly than conve... more Prolonged, sustained or extended release systems, release the active ingredient slowly than conventional dosage forms similarly administered. Tamsulosin is a selective, potent and competitive α 1 -adrenoreceptor antagonist. It has a greater affinity for the α 1A -receptor subtype and is indicated to treat uretheral stone symptoms associated with benign prostatic hyperplasia. In the present work, attempt was made to develop an once daily sustained release matrix tablet of Tamsulosin hydrochloride. Hydroxy propyl methyl cellulose was used as a hydrophilic matrix polymer. The formulation showed acceptable pharmacotechnical properties and HPLC assay requirements. The present work also involves application of Higuchi's equation, Drug release kinetics, Korsmeyer's and Hixsen-crowell plots. In vitro drug release studies indicated a sustained release pattern.
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Papers by Hareesh R