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Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health ...
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Low energy, brain fog, and poor recovery aren’t just part of getting older—they’re often signs that your cells are underperforming. And one major reason? They’re starved for oxygen. In this episode of Extend, I talk with Dr. Scott Sherr, a hyperbaric medicine specialist who helps patients and doctors worldwide use oxygen therapy to restore cellular…
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Fatigue, brain fog, joint pain, blood pressure that won’t budge, these aren’t isolated symptoms. They’re your cells signaling that something’s off. In this episode of Extend, I sit down with Dr. Bill Rawls, a board-certified OB/GYN who now focuses entirely on cellular health. We explore why most chronic illness isn’t about your diagnosis, it’s abou…
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Your doctor says your health problems are genetic, so you're destined for the same fate. But what if that's completely wrong? In this episode of Extend, I'm joined by Professor Tim Spector, one of the world's leading microbiome researchers, to reveal the truth: your gut bacteria have more control over your health than your genes do. We explore Tim'…
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What if the real reason you’re gaining weight, feeling wired, or struggling to nourish your family isn’t about willpower—but the culture you live in? On this episode of Extend, I’m joined by Shawn Stevenson—nutritionist, bestselling author, and host of The Model Health Show—to explore how our food environment, not personal discipline, is fueling th…
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Back pain is one of the most common health issues—but it’s also one of the most misunderstood. In this episode of Extend, I’m joined by Dr. Grant Elliott, a physical therapist and founder of RehabFix, to unpack the real reasons people stay stuck in chronic pain and what it actually takes to recover. We break down why most diagnoses like sciatica or…
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You’re bloated. Tired. Anxious. Maybe even burnt out. You’ve tried the diets, the supplements, the meditation apps… But you’re still not healing. Why? In this episode of Extend, I’m joined by Elissa Goodman, a holistic health expert and cancer survivor, to explore the deep connection between gut health, inflammation, and overall well-being. We dive…
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What if your bloating, fatigue, or fertility struggles aren’t separate issues, but signs of a deeper imbalance no one’s connected yet? In this episode of Extend, I’m joined by Dr. Robin Berzin, founder of Parsley Health, and we dig into how functional medicine uncovers the why behind your symptoms and why conventional care keeps missing it. We talk…
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What if the root cause of burnout, inflammation, and hormone dysfunction isn’t just physical—but energetic? In this episode of Extend, I sit down with Dr. Pedram Shojai—Taoist monk, doctor of Oriental medicine, and author of The Urban Monk—to explore how ancient wisdom meets modern health. We unpack why true healing requires addressing your qi (lif…
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What if your exhaustion, brain fog, or cravings aren’t a motivation problem—but a sleep problem no one’s diagnosed yet? In this episode of Extend, I’m joined by Dr. Michael Breuss, a sleep specialist, and we dig into why so many high performers are chronically under-recovered, why sleep disorders go undetected for years, and how wearables are both …
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Most people focus on physical health. But after years of practicing medicine, I’ve seen this truth again and again: you can’t heal your body if your mind and nervous system are stuck in survival mode. In this episode of Extend, I sat down with Kelly Gores, creator of HEAL and founder of WellSet, to explore how trauma, stress, and emotional blocks d…
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What if aging isn’t just inevitable—but programmable? In this episode of Extend, I sit down with Dr. Kara Fitzgerald, pioneering epigenetic researcher and author of Younger You, to explore how your daily choices—food, movement, sleep, stress—can literally rewire your genes to slow down aging. We unpack her groundbreaking study showing biological ag…
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Most people are treating stress with the wrong tools, and it’s silently sabotaging their longevity. In this episode of Extend, I sit down with Jen Batchelor, Ayurvedic health optimizer and co-founder of Kin Euphorics, to talk about what your nervous system actually needs to feel calm, connected, and well. We dive into what adaptogens are really doi…
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What if your real age isn’t on your driver’s license—but buried in your biology? In this episode of Extend, I’m joined by Chris Mirabile, founder of NOVOS and one of the few people actually slowing down his pace of aging. We break down why the average person is aging faster than they realize, and how mainstream medicine is decades behind when it co…
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Most supplements don’t work. Some might actually harm you. That’s the hard truth no one in the $50 billion supplement industry wants to say out loud—but we will. In today’s episode of Extend, I’m joined by Steve Martocci, co-founder of SuppCo, to expose what’s really going on behind the labels. We break down why “clinically dosed” means nothing, wh…
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What if the reason you can’t focus, feel chronically overwhelmed, or keep slipping into the same unhealthy habits… isn’t a discipline problem, it's your brain’s biology working against you? In this episode of Extend, I'm joined by Dr. Austin Perlmutter, board-certified internal medicine physician and neuroscientist, to explore how inflammation hija…
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In this episode of Extend, we’re digging into one of the most dangerous—and most overlooked—drivers of heart disease: LP(a). You could have a clean lifestyle, normal labs, and still be at high risk for a heart attack or stroke. Why? Because LP(a) isn’t included in standard cholesterol tests—and 1 in 5 people have elevated levels without knowing it.…
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What if the reason you're tired, inflamed, or not recovering the way you used to has nothing to do with aging, and everything to do with your NAD system being under attack? In this episode of Extend, I’m joined by Dr. Charles Brenner, the scientist who discovered nicotinamide riboside (NR) and one of the leading experts on NAD metabolism. We unpack…
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Most people know mindset matters, but almost no one knows how to actually train it for better health, performance, and longevity. In today's episode of Extend, I'm joined by David Nurse, NBA mindset coach and best-selling author. We dive deep into why mindset is the real missing piece in most health optimization plans, and how flow states, identity…
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What if the hidden toxins in your everyday life are secretly sabotaging your health, hormones, and longevity? Most people underestimate how deeply their health is impacted by toxins—and conventional medicine isn’t addressing the root of the issue. In this episode of Extend, I'm joined by Dr. Aly Cohen, renowned integrative rheumatologist, environme…
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In this episode of Extend, we’re rethinking everything you’ve been told about cholesterol. For decades, the focus has been on lowering LDL, but that’s only part of the story. The truth? LDL and total cholesterol are outdated metrics. If you're still relying on those alone to assess your heart health, you’re missing the bigger picture. I’ll break do…
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What if the secret to better energy, fat loss, and gut health wasn’t more discipline… but a smarter strategy? Most people are hacking the wrong system—and it’s backfiring. In this episode of Extend, I’m joined by Joel Greene, creator of the VEEP Nutrition System and one of the most innovative minds in metabolic health. We break down the science beh…
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What if our food system wasn’t designed for our health, but for shelf life, convenience, and corporate profit? In today’s episode of Extend, I’m joined by Ricky Silver, CEO of Daily Harvest, who brings a rare inside-the-industry view of how our food system really works, and how we can change it. We explore how government subsidies, processed foods,…
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What if the reason your supplements aren’t working has nothing to do with your body—and everything to do with what’s in the bottle? In this episode of Extend, I’m joined by biochemist and ingredient formulator Shawn Wells, a leading voice in evidence-based supplementation and mitochondrial health. Together, we uncover why so many products fail to d…
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What if menopause didn’t have to be a challenge, but an opportunity? In this episode of Extend, I’m joined by Zora Benhamou, host of the Hack My Age podcast, to challenge the common narrative around menopause. Zora shares a refreshing perspective that empowers women to see this stage of life as a chance for reinvention, growth, and better health. W…
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Brain fog, forgetfulness, and lack of focus are becoming the norm, but they don’t have to be. In this episode of Extend, I’m joined by Jim Kwik, a world-renowned brain coach and author of the bestselling book Limitless, to uncover how to unlock your brain’s full potential. We dive into the science of neuroplasticity, daily habits that sabotage your…
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In today’s episode of Extend, we’re tackling a crucial health issue: high blood pressure. Often called the "silent killer," high blood pressure increases your risk for heart attacks, strokes, kidney disease, and more. But what if you could prevent these risks before they escalate? I’ll break down why measuring your blood pressure at home is far mor…
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Ever feel stuck, even when you're doing all the right things? In this episode, Dr. Shah sits down with Dr. Alok Trivedi, also known as Dr. Rewire, to explore how our unresolved traumas, subconscious beliefs, and identity patterns silently shape our health, habits, and happiness. You’ll discover how trauma wires into the nervous system, why mindset …
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With shelves full of flashy promises, it’s time to cut through the noise. In this episode, Dr. Shah and Dr. Greg Kelly explore what science actually says about supplements—and what your body truly needs to perform at its best. You’ll learn how nootropics, adaptogens, and probiotics influence brain health, stress resilience, and longevity. Backed by…
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Inflammation drives nearly every chronic disease, yet most people overlook a key player in regulating it: the vagus nerve. This critical nerve connects brain to body, controlling digestion, heart rate, immunity, and recovery. But chronic stress shuts it down, leading to poor vagal tone, dysregulated inflammation, and reduced resilience. In this epi…
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Heart disease is still the number one cause of death, yet most people don’t realize how preventable it actually is. In this solo episode of Extend, I’m kicking off our new series on preventative medicine by breaking down the essential tests and metrics you need to know to protect your heart. I’ll walk you through the four key areas I evaluate in ev…
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Most people don’t think about their health until something goes wrong—but what if you could catch potential issues before they become a problem? Studies show that up to 70% of serious health conditions are preventable with early detection, yet traditional healthcare often focuses on treating symptoms rather than identifying root causes. Taking a pr…
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In today’s episode, I sat down with Rajeev Kapur, an AI expert and author of AI Made Simple, to explore the rapidly evolving role of AI in medicine. We dive into how AI is enhancing diagnostics, optimizing treatment plans, and helping patients take control of their own health data. We also break down common fears and misconceptions—will AI replace …
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Bone health is often overlooked until a fracture happens—but by then, the damage has already been done. What most people don’t realize is that bones are not just structural; they play a critical role in metabolism, hormone regulation, and long-term vitality. In fact, emerging research shows that osteoporosis and bone loss start much earlier than ex…
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What if the symptoms you've been chalking up to "normal life"—brain fog, persistent insomnia, chronic fatigue, and the stubborn belly fat—were actually signs of a deeper disconnection from what makes us truly human? In this episode, I sit down with Jeff Krasno, author of "Good Stress: The Health Benefits of Doing Hard Things," to explore the hidden…
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We often hear about the latest treatments for chronic disease, but what if you could prevent these conditions before they even begin? The truth is, most of the top 10 causes of death are entirely preventable, yet our healthcare system focuses on treating disease rather than stopping it in its tracks. In today’s episode of Extend, I’m breaking down …
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Fasting has been praised as a powerful tool for weight loss, metabolic health, and longevity, but is it always beneficial? The truth is, fasting can either optimize your biology or work against you, depending on how, when, and for how long you do it. Research now suggests that skipping breakfast, a common intermittent fasting practice, is linked to…
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What if the symptoms you’ve been chalking up to aging, low energy, brain fog, stubborn belly fat, and lack of motivation, were actually signs of a deeper hormonal imbalance? The truth is, testosterone levels in men have been plummeting for decades, and it’s not just about aging. Environmental toxins, chronic stress, poor sleep, and nutrient deficie…
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Have you ever wondered why gut health is at the root of everything, from metabolism and cravings to immunity and even mental clarity? Why do some people struggle with weight gain, energy crashes, and digestive issues despite eating well? And could the rise of GLP-1 medications like Ozempic be a sign that we’ve been ignoring a natural solution all a…
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What if everything you’ve been told about nutrition is only half the story? It’s not just about avoiding carbs, counting macros, or following the latest health trend—it’s about how food impacts your metabolism, gut, and long-term health on a deeper level. The problem? Most people are stuck in a cycle of restrictive diets, misinformation, and ultra-…
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Sleep isn't just about rest, it's a critical pillar of metabolic health, cognitive function, and longevity. In this solo episode of Extend, I dive deep into the science of sleep routines and circadian rhythms. I share how proper sleep habits are foundational to the new healthcare paradigm focused on vitality rather than disease management. I explai…
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Have you ever felt like mental health care is stuck in the past? Why are rates of depression, anxiety, and even conditions like autism skyrocketing in today’s world? And why does traditional treatment often fall short? Spoiler: the answer lies deeper than just brain chemistry… it’s all about your metabolic health. In this week’s episode of Extend, …
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What if the key to peak performance and longevity isn’t just in your workouts, diet, or sleep, but in how well your body handles stress? Optimizing your health isn’t just about the latest supplements or fitness trends, it’s about understanding your nervous system, heart rate variability (HRV), and how small daily habits shape your resilience over t…
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If you’re struggling to fall asleep, waking up in the middle of the night, or feeling groggy in the morning, the problem might not be you—it might be your sleep environment. Most people don’t realize just how much their bedroom setup impacts sleep quality. In this episode of Xtend, I’m breaking down exactly how you can optimize your space to promot…
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Do you ever feel like your wellness journey is missing something? We often focus on physical health—what we eat, how we exercise—but overlook the powerful role our mind plays in driving true transformation. From reducing stress to optimizing focus, your thoughts and beliefs shape every aspect of your well-being. The key to lasting change may be clo…
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Most people think longevity is about expensive treatments, cutting-edge technology, or the latest supplements. But what if the real key to aging well comes down to something much simpler, understanding your body, making informed choices, and building habits that last? Healthspan matters more than lifespan, and the small, consistent actions you take…
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Sleep isn’t just about rest, it’s a critical pillar of metabolic health, cognitive function, and longevity. Poor sleep quality is linked to increased risks of cardiovascular disease, diabetes, neurodegeneration, and even cancer. In this episode of Extend, I break down how tracking your sleep can uncover hidden disorders, optimize recovery, and impr…
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Most of us think hitting the gym a few times a week is enough—but what about the other 23 hours of your day? Your daily habits could be silently limiting your mobility and longevity without you even realizing it. In this episode of Extend, I sit down with Kelly and Juliet Starrett, bestselling authors of Built to Move and pioneers in the world of m…
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How often do you find yourself struggling with cravings, feeling like your hunger is out of control, or wondering why weight loss feels impossible? The truth is, your gut is running the show, specifically, a powerful hormone called GLP-1 that regulates appetite, metabolism, and even inflammation. And the secret to boosting it naturally? Bitterness.…
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You hit the gym, push your limits, and stay consistent, but if you’re skipping recovery, you’re actually holding yourself back. Overtraining doesn’t just slow muscle growth; it ramps up inflammation, messes with your metabolism, and puts unnecessary stress on your heart. In today’s episode of Extend, I’m breaking down why recovery is the missing pi…
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How many nights have you told yourself you’ll catch up on sleep later? You push through exhaustion, thinking it’s just part of life. But here’s the truth: chronic sleep deprivation isn’t just making you tired—it’s rewiring your brain, disrupting your hormones, and holding you back from living your best life. In this episode of Extend, I sit down wi…
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