“Got Knowledge Doc” Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Eac ...
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A joint project of Costs of Care and the ABIM Foundation, the Teaching Value in Health Care Learning Network is a dynamic community of medical residents, students, faculty and others who are committed to learning and teaching the principles of stewardship and high-value care. Our podcasts include conversations with leaders and innovators who are implementing successful tools and strategies in their organizations.
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The California Work Comp Report is a podcast for California workers' compensation professionals and injured workers. In a series of interviews with Dr. John Alchemy, physicians, QMEs, and other industry experts, all aspects of California workers' compensation are demystified. The series also covers current events related to workers’ compensation.
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Sweat 💦, Synapses 🧠, Survival 🛡️: Exercise and the Ageing Brain
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4:10🧠 Regular endurance exercise boosts brain health by increasing blood flow 💓, enhancing neuroplasticity 🔁, and reducing inflammation 🔥. 🏃♂️ High cardiorespiratory fitness (CRF) lowers dementia risk 🧩, supports memory 📝, and promotes the release of powerful brain molecules like BDNF 🧬 and irisin 💪. ✨ In short: Move more, age slower, think sharper!…
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🔬 Cataracts Decoded: Clarity, Surgery, and the Silver Years 👓”
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2:57👁️ Cataracts are a common cause of vision loss in older adults, leading to blurry vision, glare, and difficulty with daily tasks. 💉 Surgery is safe, quick, and effective — restoring clarity, reducing fall risk, and even lowering dementia risk. 🔬 Advanced lenses can reduce dependence on glasses, while intraocular antibiotics help prevent rare infect…
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Staph Aureus Bacteremia 🦠 Detect. 💊 Treat. 🔍 Control the Source!”
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3:54🦠 Staphylococcus aureus bacteremia (SAB) is a deadly bloodstream infection with high rates of complications like endocarditis and abscesses. 💉 Early detection, MRSA coverage with vancomycin/daptomycin, and source control (🪛 remove catheters, drain abscesses) are critical. 🔍 Use echocardiography and VIRSTA score to guide management. ✅ Once susceptib…
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🧠 People often say they want big wins (like lotteries), but in practice, they choose what wins more often—even if it pays less. 🎮 In experiments, when outcomes are shown side-by-side, we tend to favor the “frequent winner.” 📉 This bias can make us overlook rare, high rewards—shaping real-world choices in money, health, and risk. 🔍 Bottom line: It’s…
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Dr. RR Baliga’s Philosophical Discourses: Zhuangzi (China, c. 369–286 BCE) – Taoist Philosopher
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3:25Zhuang Zhou, also known as Zhuangzi, was an influential 4th-century BCE Chinese philosopher during the Warring States period. As a foundational figure of Taoism, he authored the Zhuangzi, a text known for its profound philosophical insights, parables, and critiques of societal norms, emphasizing personal freedom and harmony with the Tao. His ideas …
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Hands Down, Cream Wins! 🖐️🧴💥 Delgocitinib vs Alitretinoin in Chronic Eczema
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3:56🧴 Delgocitinib cream outperformed oral alitretinoin in treating severe chronic hand eczema over 24 weeks. 📉 Greater reduction in HECSI, 😊 better quality of life, and ⚠️ fewer side effects make it a promising non-steroidal alternative. 💊 Time to rethink systemic pills — topical wins hands down! 🖐️✅By MasterMedFacts LLC
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🧠🦴🚼 “Brains, Balance, and Birth: Cracking the Pelvic Code
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2:53🧬 Human pelvic evolution reflects a tug-of-war between 🚶♀️ efficient walking, 🧠 growing brains, and 🚼 safe childbirth. Using AI and genetic data from 31,115 individuals, Xu et al. found the pelvis is highly heritable, sex-dimorphic, and shaped by multiple selective pressures—not just bipedalism or birth. Larger canals ease delivery but risk 💥 pelv…
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🫁💥 “Lung Clues & Blood Blues: How Tiny Lung Vesicles Spark Deadly Cancer Clots” 🧬🩸
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2:43🩸 Summary: Lung interstitial macrophages, activated by tumor-derived CXCL13, release integrin β2⁺ extracellular vesicles (sEVs) 🧬 that bind platelet GPIb 🧲, triggering clot formation across the body. These sEVs are both a driver of cancer-associated thrombosis and a potential biomarker for early risk detection 🎯, offering safer, targeted therapeuti…
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Inflammation 🔥, Dopamine 💊, and Apathy 😐: A Neuroimmune Pathway in Brain Fog?
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3:30Cancer cachexia isn’t just weight loss—it’s a hijacking of motivation 😔. Elevated IL-6 🔥 activates a brainstem-to-basal ganglia circuit 🧠 that suppresses dopamine 💊 in the nucleus accumbens, leading to effort-based apathy 💤. Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway 💡.…
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“🧠 Fewer Strokes, 🚫 No Bleeds, ✅ Stronger Choice: Clopidogrel After PCI?
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4:17🧪 SMART-CHOICE 3 in a Nutshell 🟣 Clopidogrel beat 🟠 aspirin post-PCI: 📉 Fewer MACCE (4.4% vs 6.6%) 🩸 Same bleeding risk 🍽️ Fewer GI events ⚠️ Editorial: Fragile stats, late benefit, open questions on lifelong therapy. 🎯 Verdict: Promising—but not bulletproof.By MasterMedFacts
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🔋 Mitochondrial transplants are emerging as a powerful therapy to repair damaged cells, boost energy, and even reverse aging. From saving 🫀 baby hearts to protecting 🧠 stroke-affected brains, this tiny powerhouse may revolutionize medicine—one cell at a time. 🧬💉✨By MasterMedFacts LLC
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Dr. RR Baliga’s Philosophical Discourses: Plato (Greece, 427–347 BCE) – Founder of the Academy
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4:48Plato (c. 428-348 BCE), a foundational figure in Western philosophy, was a student of Socrates and teacher of Aristotle. He established the Academy in Athens and is known for his theory of Forms, dialogues on justice, ethics, and politics, and lasting influence on philosophy, science, and education.By MasterMedFacts LLC
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Mitochondria the Tiny Travelers, Big Impact, Bold Future
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1:49🧬 Mitochondria are on the move! Once thought to stay put, these powerhouses travel between cells 🚀—healing neurons 🧠, boosting immunity 🛡️, and even aiding cancer cells ⚠️. Scientists are now exploring how to harness this dynamic dance for future therapies 💉.By MasterMedFacts LLC
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From Cold to Bold: The Legacy of Winter Conception
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3:21❄️ Conceived in the Cold? Individuals conceived during colder months show higher brown fat activity, increased thermogenesis, and lower BMI as adults. 🔬 Using PET/CT, NIR-TRS, and doubly labeled water (DLW), the study linked preconception cold exposure to greater energy expenditure and reduced visceral fat. 🧬 The key factor: Temperature and its diu…
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“Heart on Fire? Timing Colchicine Right ⏳🧯🏥”
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3:15Colchicine 💊, once a humble gout remedy, is now reshaping coronary care 🫀. Trials show it reduces events in stable CAD ✅, but its benefit post-MI ⛑️ depends on timing ⏰. Inflammation matters — and so does when we strike. Colchicine in CAD: Small Pill, Big Debate 💊🔥🫀 An ancient anti-inflammatory has found new life in cardiology — reducing heart atta…
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The Kilimanjaro Cure 🌋🥬:: 🧬: How Heritage Diets Heal
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3:01🌿 Switching to a Western diet 🍔 increased inflammation 🔥 and metabolic dysfunction. 🍌 Mbege and traditional foods calmed the immune system 🧘 and boosted IL-10 🕊️.By MasterMedFacts LLC
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“Salted Truths: 🧂❤️⚖️ Rethinking Sodium for Heart and Kidney Health”
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2:04Not all salts are created equal! 🧂 Sodium chloride raises blood pressure and harms the heart 😈, while sodium bicarbonate may protect kidneys and improve outcomes in CKD/HF patients 🛡️🫀. Chloride channels (CLICs) play a hidden but vital role in heart health 🔌❤️. We need large RCTs 🧪📊 to guide smarter, personalized salt strategies for better cardiova…
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💊 Oral Semaglutide Enters the Arena — The SOUL Trial
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3:11The SOUL trial 🧪 showed that oral semaglutide 💊 significantly reduced major cardiovascular events ❤️ (MACE) in people with type 2 diabetes 🩸 and ASCVD/CKD 🚑. Over ~4 years, it cut heart attacks 💥, lowered HbA1c 📉, reduced weight ⚖️, and inflammation 🔥 — all with a once-daily pill 🕊️ and no rise in serious side effects.…
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Dr. RR Baliga’s Philosophical Discourses: Mozi (China, c. 470–391 BCE) – Founder of Mohism
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3:48Mozi, a prominent Chinese philosopher during the Warring States period, founded Mohism, a school of thought emphasizing universal love, meritocracy, anti-war principles, and consequentialist ethics. He advocated for frugality, social welfare, and pragmatic governance guided by Heaven’s will.By MasterMedFacts LLC
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Coronary Artery Disease: Fix the Future, Not Just the Flow 🌍🫀🛠️”
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2:14The Lancet Commission calls for a shift from focusing on late-stage ischaemia to targeting early atherosclerosis (ACAD) 🫀🔍. By detecting and treating plaque early, we can prevent heart attacks, reduce deaths, and promote lifelong heart health 🌍❤️💡.By MasterMedFacts LLC
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🧠💉 “Shots, Shingles, and Sharp Minds: The Brain-Boosting Power of a Vaccine
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2:16💉 A natural experiment in Wales showed that the shingles vaccine (Zostavax) reduced dementia risk by 20% over 7 years. 🧠 The study used a clever birthdate cutoff to mimic randomization and avoid confounding. 👩🔬 Women benefited more, suggesting immune or viral mechanisms beyond shingles prevention. 📊 Findings offer hope for low-cost, brain-protecti…
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🚶♂️💉 Giant Strides with Weekly Semaglutide Jabs!
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3:04🚶♂️ The STRIDE trial tested semaglutide in patients with PAD and type 2 diabetes. 💉 Weekly injections for 52 weeks improved walking distance, pain-free mobility, and quality of life. 📊 Results showed significant gains vs placebo, with low adverse events. 🌟 Semaglutide may offer a new stride forward in treating functional limitations in PAD.…
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Microbial Enzymes, Human Time: The Xenotopic Way to Live Longer
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3:11🧬 Xenotopic synthetic biology explores using enzymes from microbes (like bacteria and yeast) to reprogram human metabolism and delay aging. 🔋 These “borrowed” enzymes target amino acid levels, mitochondrial function, and redox balance to boost healthspan and fight age-related diseases. 🦠 From methioninase to NDI1 and AOX, these tools may turn micro…
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🏃♂️💔 Heartbreak at the Finish Line: Racing Against Cardiac Arrest ⚡🚑
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2:55🏃♂️💔 In a study of 29 million race finishers (2010–2023), cardiac arrest rates during marathons and half-marathons stayed steady, but deaths dropped by half. 🧠⚡ Rapid CPR and AED use saved lives, with coronary artery disease—not hypertrophic cardiomyopathy—being the top culprit. 🫀🚑By MasterMedFacts LLC
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🏃♂️🧠💡 Move. Spark. Remember: The Brain Boost of Exercise
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2:16🧠 Exercise is a powerful neuroprotective tool—it boosts memory, preserves brain volume, and reduces dementia risk. 💪 Through exerkines like BDNF and irisin, it sparks neurogenesis, clears inflammation, and enhances brain plasticity. 🌱 It also nurtures your gut microbiome and rewires your genes, making movement medicine for the mind.…
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Dr. RR Baliga’s Philosophical Discourses: Socrates (Greece, 469–399 BCE) – Classical Philosopher
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2:51A brief overview of Socrates, the classical Greek philosopher widely regarded as the founder of Western philosophy. Known for his Socratic method of questioning, he profoundly influenced ethical thought, epistemology, and later philosophical traditions.By MasterMedFacts LLC
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🎙️ “🥗 Plants, 🍽️ Plates, and 🤔 Paradoxes: Decoding Diets for a Long Life”
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5:26🍎 In this episode, we unpack a 30-year study on how diet influences aging. 🥗 AHEI, DASH, and Mediterranean diets boost your odds of healthy aging—by as much as 86%! ⚠️ But not all plant-based diets are equal: hPDI underwhelms, likely due to excluding protective animal foods like fish and dairy. 🚫 Ultra-processed foods, sugary drinks, and trans fats…
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Hearts on the Line: Choosing Wisely, Saving Lives ❤️🫀
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5:19🫀 Heart transplantation is a life-saving treatment for end-stage heart failure, but donor hearts are scarce. 🔍 Donor selection is complex, involving factors like age, heart size, LV function, and comorbidities. 🌍 The U.S. is more conservative than Europe, with higher donor heart nonuse rates. ⚙️ New tools like Predicted Heart Mass (PHM), Organ Care…
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⚡ Cardiogenic Shock Strategy: 👁️ Spot It • ✋ Stop It • 💓 Save Lives
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5:58🚑 A rapid-fire guide to cardiogenic shock — from first suspicion to life-saving interventions. 🩺 ACC’s latest on Cardiogenic Shock: 👁️ Early detection with SUSPECT CS 💉 First-line meds: norepinephrine & dobutamine 🛠️ tMCS for refractory cases (Impella, VA-ECMO) 🏥 Transfer to Level 1 centers 🤝 Team-based care = better outcomes 💡 Act fast, save lives…
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Leg Cramps at Night 💤, Relief in Sight 🛌, Powered by Vitamin K2 💊
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3:18🧪 A randomized clinical trial in older adults (65+) found that Vitamin K2 (menaquinone-7, 180 μg/day) significantly reduced nocturnal leg cramps in terms of frequency, severity, and duration—with no adverse effects reported. 🌙🦵💊 This safe (?), over-the-counter supplement may offer a simple, science-backed solution for painful nighttime cramps—avoid…
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📊 Too much sitting hurts the heart. 🧍♂️ Ajufo et al. (2024) tracked 89,530 people using accelerometers and found that 🪑 >10.6 hours/day of sitting sharply increases the risk of ❤️ heart failure, 💔 heart attacks, 💓 AFib, and ⚰️ cardiovascular death. 🏃 Even active people aren’t fully protected. 🔁 Replacing just 30 minutes of sitting with movement—🕺 …
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Young, Fit… Gone? The Hidden Dangers of Cardiac Arrest
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6:08🧑⚕️💔 Young, Fit… Gone? Every year, thousands of seemingly healthy young adults suffer sudden cardiac arrest (SCA) outside the hospital. 📉 Only 9–16% survive to discharge — yet 90% of survivors leave with good brain function. 🔍 Many have hidden risk factors — hypertension, diabetes, even genetic arrhythmia syndromes like Brugada or Long QT. ⚡ Rapid…
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Dr. RR Baliga’s Philosophical Discourses: Gautama Buddha (India, c. 563–483 BCE) – Founder of Buddhism
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3:13Siddhartha Gautama, known as the Buddha (“the awakened one”), was a spiritual teacher who founded Buddhism in the 5th or 6th century BCE in South Asia. His core teachings include the Middle Way, the Four Noble Truths, and the Noble Eightfold Path, emphasizing mindfulness, ethics, and liberation from suffering.…
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🔥 Sizzle, 🔄 Swap, 💪 Survive: Oils That Heal, Fats That Harm
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3:22•Olive. Canola. Soybean. •Not just flavor—they’re lifelines. 🌱 •Every 10g a day drops mortality by 16%. •They don’t just cook food—they cook up longevity? 🔥⏳By MasterMedFacts LLC
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🧬 Your mother’s X chromosome may shape how your brain ages. In female mice, when only the maternal X chromosome (Xm) is active, older animals show worse memory 🧠🕳️ than those with random X-inactivation. This is due to imprinted genes — some only expressed from the paternal X (Xp) — which are silent when Xm dominates. 🧠💡 Using CRISPR–Cas9, researche…
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Genes, Families, and Households: Rethinking Biobank Science
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6:04🔬 Confounding, Clarity, and Causality Family-based biobanks 🧬 are the next frontier in genetic research—tackling bias 🧠, boosting causal inference 🎯, and revealing insights hidden in the noise of population studies 🌍. It’s not just about big data—it’s about better data 👨👩👧👦.By MasterMedFacts LLC
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🧠 Brain aging decoded! Scientists identify 64 genes & 13 blood proteins linked to aging.
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3:11🧠 Brain Aging & Research Advances 🔍 Key Findings: • Brain Age Gap (BAG): Difference between estimated and chronological brain age. • 64 genes identified as influencing brain aging. • 13 proteins in blood linked to accelerated/slowed brain aging. 🩺 Potential Interventions: • 13 anti-aging drugs (e.g., Rapamycin, Dasatinib) show promise in slowing de…
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Brain Slime to the Rescue! 🧠🛡️ How Mucins Protect Against Aging & Cognitive Decline 🚀
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4:58The blood-brain barrier (BBB) 🛡️ protects the brain from harmful molecules but weakens with aging 🧓, leading to neuroinflammation 🔥 and cognitive decline 📉. Mucins 🧬, slippery proteins in the glycocalyx 🏗️, help maintain BBB integrity 🧠. This study found that mucin loss 🚨 increases BBB permeability, allowing toxins to enter. Using gene therapy 🧪, r…
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🧠 Migraine is a complex neurological disorder affecting 1 billion people worldwide. Historically misunderstood, it was once seen as a vascular or psychological issue but is now recognized as a brain network dysfunction involving the hypothalamus and limbic system. 💊 Gepants and CGRP blockers have revolutionized treatment, though they only work for …
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“Alcohol: A Double-Edged Sword ⚖️🍷 – Cancer, Heart Risks & What You Need to Know!”
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3:38Alcohol is a proven carcinogen 🚨, increasing the risk of at least 7 cancers (mouth, throat, breast, liver, etc.) 🦠💀. Even small amounts (5g ethanol/day) raise cancer risk, with no safe threshold 📊🚫. Similarly, exceeding 14 drinks/week (men) or 7 (women) raises CHD risk by up to 43% 💔📈. Past claims of heart benefits from moderate drinking are now be…
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Dr. RR Baliga’s Philosophical Discourses: Heraclitus (Greece, c. 535–475 BCE) – Pre-Socratic Philosopher
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3:29Heraclitus (c. 500 BC), a pre-Socratic philosopher from Ephesus, is renowned for his doctrine of perpetual change and the unity of opposites, encapsulated in the phrase “Everything flows” and “No man ever steps in the same river twice.” His concept of logos as the rational order of the universe influenced ancient and modern philosophy, including th…
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☕ Brewed for Your Gut? 🔬 Coffee, Microbiome, & Metabolic Magic! 🦠✨
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2:34☕ Coffee & Gut Microbiome 🦠 🔬 A multi-cohort study (N = 22,867) found a strong link between coffee consumption and the gut bacterium Lawsonibacter asaccharolyticus. 🧪 Metabolomics identified key coffee-derived metabolites like quinic acid, hippurate, and trigonelline. 📊 Machine learning (AUC = 0.89) confirmed microbiome composition predicts coffee …
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Move over, Bionic Man—this titanium heart 🫀⚙️ just made science fiction a reality! 🚀💙
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2:22By MasterMedFacts LLC
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🔬 Antioxidants & Health: The Science Behind the Hype ❌❤️
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2:39🔬 Antioxidants & Health: Myths vs. Reality ❌🍊💊 Despite popular belief, vitamins C & E do not reduce the risk of cancer, heart disease, or chronic illness 🚫❤️. High doses of vitamin A increase the risk of hip fractures & prostate cancer ⚠️🦴, while vitamin E is linked to respiratory infections, prostate cancer, and even death 😷❌. However, a specific …
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“🩸 Iron & Folate: The Power of Nutrients for a Healthy Life 💪🍎”
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3:34🔬 Anemia & Folate: Key Insights 🩸 Anemia is primarily caused by iron deficiency in the U.S., especially in pregnancy (30% prevalence). 📊 NHANES data shows high iron deficiency in young females (up to 77.5% at ferritin 45 mg/day may cause nausea & constipation. 👶 Maternal iron status affects infant birth weight, and delayed cord clamping improves ne…
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Vitamin B12: Essential for Health 🩸🧠 Vitamin B12 is crucial for red blood cell formation, brain function, and DNA synthesis. Found in animal-based foods 🥛🍳🐟, those on vegan diets need fortified foods or supplements 💊. Deficiency can cause anemia, neurological issues, and cognitive decline ⚠️. High-risk groups include vegans, vegetarians, older adul…
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☀️ Vitamin D: The Sunshine Nutrient for Strong Bones & Immunity? 🦴🛡️”
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5:59Vitamin D is essential for bone health 🦴, immune function 🛡️, and muscle strength 🏋️. Deficiency is common and affects women 👩⚕️, young adults 🧑🎓, and non-Hispanic Black Americans. Main sources include sunlight ☀️, oily fish 🐟, eggs 🥚, and fortified foods 🥛. Recommended intake is 600-800 IU/day 💊. Studies show mixed results 📊, but it may help wit…
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🔥 Vitamin D & Multiple Sclerosis: Defending the Nervous System 🧠🛡️
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3:03🧠 High-dose Vitamin D (100,000 IU biweekly) reduced disease activity in Clinically Isolated Syndrome (CIS) of MS 🌞📉. Patients had fewer MRI lesions 🖥️, longer time to disease activity ⏳, but no significant impact on relapses ❌. Well-tolerated with minimal side effects ⚕️, These findings support further research on Vitamin D as an MS therapy 🔬🚀.…
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BEAM-302: Rewriting Genes, Restoring Health – A Breakthrough in AATD Therapy! 🔬🚀
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3:30🔬 BEAM-302 is a liver-targeting gene therapy using base editing to correct the PiZ mutation in Alpha-1 Antitrypsin Deficiency (AATD). 🧬 I t increases functional AAT 🫁 while reducing toxic Z-AAT, showing up to 78% reduction at the 60 mg dose. 📊 The Phase 1/2 trial demonstrated dose-dependent efficacy, a well-tolerated safety profile, and no serious …
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Dr. RR Baliga’s Philosophical Discourses: Confucius (China, 551–479 BCE) – Founder of Confucianism
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4:02Confucius (c. 551–479 BCE), a renowned Chinese philosopher and teacher, founded Confucianism, emphasizing morality, family loyalty, social harmony, and virtuous governance. His teachings, compiled in the Analects, profoundly influenced Chinese culture, ethics, and education.By MasterMedFacts LLC
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