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Flip and Mozi

Tinkercast | Wondery

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Created by Tinkercast in collaboration with The Pop Ups, Flip and Mozi is an intergalactic musical journey that brings conservation into the conversation for kids and their grown-ups. Available every Thursday or listen ad-free and 1 week early and ad-free on Wondery+, Wondery+ Kids on Apple Podcasts, or on Amazon Music with a Prime membership or Amazon Music Unlimited subscription. Visit flipandmozi.com for conversation starters, book lists and activities to keep the wow rolling long after t ...
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β€œGot Knowledge Doc” Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Eac ...
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Az AlkotΓ‘s Útja 2007-ben jelent meg a Tilos RΓ‘diΓ³ szΓΆvetΓ©ben. A rΓ©szvΓ©teli alapon szervezΕ‘dΕ‘ adΓ‘sfolyam, azΓ³ta folyamatosan, heti egy alkalommal jelentkezik, Γ©s figyelem Γ©s reflexiΓ³-befektetΓ©skΓ©nt mΕ±kΓΆdik. Az Γ‘ltalΓ‘ban egyetlen vendΓ©gre Γ©pΓΌlΕ‘, hallgatΓ³i hozzΓ‘szΓ³lΓ‘sokra nyitott adΓ‘s, egyszersmind diszkurzΓ­v platformot is nyΓΊjt. Az eredeti cΓ©loknak megfelelΕ‘en a kortΓ‘rsmΕ±vΓ©szeti szcΓ©na szereplΕ‘it hΓ­vjuk el aktuΓ‘lis tΓ©mΓ‘krΓ³l beszΓ©lgetni. Az eddigi kb. 500+ adΓ‘sban kb. 400 vendΓ©g szerepelt, jΓ³nΓ© ...
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Mozi, a prominent Chinese philosopher during the Warring States period, founded Mohism, a school of thought emphasizing universal love, meritocracy, anti-war principles, and consequentialist ethics. He advocated for frugality, social welfare, and pragmatic governance guided by Heaven’s will.By MasterMedFacts LLC
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Not all salts are created equal! πŸ§‚ Sodium chloride raises blood pressure and harms the heart 😈, while sodium bicarbonate may protect kidneys and improve outcomes in CKD/HF patients πŸ›‘οΈπŸ«€. Chloride channels (CLICs) play a hidden but vital role in heart health πŸ”Œβ€οΈ. We need large RCTs πŸ§ͺπŸ“Š to guide smarter, personalized salt strategies for better cardiova…
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The SOUL trial πŸ§ͺ showed that oral semaglutide πŸ’Š significantly reduced major cardiovascular events ❀️ (MACE) in people with type 2 diabetes 🩸 and ASCVD/CKD πŸš‘. Over ~4 years, it cut heart attacks πŸ’₯, lowered HbA1c πŸ“‰, reduced weight βš–οΈ, and inflammation πŸ”₯ β€” all with a once-daily pill πŸ•ŠοΈ and no rise in serious side effects.…
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The Lancet Commission calls for a shift from focusing on late-stage ischaemia to targeting early atherosclerosis (ACAD) πŸ«€πŸ”. By detecting and treating plaque early, we can prevent heart attacks, reduce deaths, and promote lifelong heart health πŸŒβ€οΈπŸ’‘.By MasterMedFacts LLC
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πŸ’‰ A natural experiment in Wales showed that the shingles vaccine (Zostavax) reduced dementia risk by 20% over 7 years. 🧠 The study used a clever birthdate cutoff to mimic randomization and avoid confounding. πŸ‘©β€πŸ”¬ Women benefited more, suggesting immune or viral mechanisms beyond shingles prevention. πŸ“Š Findings offer hope for low-cost, brain-protecti…
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πŸšΆβ€β™‚οΈ The STRIDE trial tested semaglutide in patients with PAD and type 2 diabetes. πŸ’‰ Weekly injections for 52 weeks improved walking distance, pain-free mobility, and quality of life. πŸ“Š Results showed significant gains vs placebo, with low adverse events. 🌟 Semaglutide may offer a new stride forward in treating functional limitations in PAD.…
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🧬 Xenotopic synthetic biology explores using enzymes from microbes (like bacteria and yeast) to reprogram human metabolism and delay aging. πŸ”‹ These β€œborrowed” enzymes target amino acid levels, mitochondrial function, and redox balance to boost healthspan and fight age-related diseases. 🦠 From methioninase to NDI1 and AOX, these tools may turn micro…
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πŸƒβ€β™‚οΈπŸ’” In a study of 29 million race finishers (2010–2023), cardiac arrest rates during marathons and half-marathons stayed steady, but deaths dropped by half. 🧠⚑ Rapid CPR and AED use saved lives, with coronary artery diseaseβ€”not hypertrophic cardiomyopathyβ€”being the top culprit. πŸ«€πŸš‘By MasterMedFacts LLC
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🧠 Exercise is a powerful neuroprotective toolβ€”it boosts memory, preserves brain volume, and reduces dementia risk. πŸ’ͺ Through exerkines like BDNF and irisin, it sparks neurogenesis, clears inflammation, and enhances brain plasticity. 🌱 It also nurtures your gut microbiome and rewires your genes, making movement medicine for the mind.…
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A brief overview of Socrates, the classical Greek philosopher widely regarded as the founder of Western philosophy. Known for his Socratic method of questioning, he profoundly influenced ethical thought, epistemology, and later philosophical traditions.By MasterMedFacts LLC
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🍎 In this episode, we unpack a 30-year study on how diet influences aging. πŸ₯— AHEI, DASH, and Mediterranean diets boost your odds of healthy agingβ€”by as much as 86%! ⚠️ But not all plant-based diets are equal: hPDI underwhelms, likely due to excluding protective animal foods like fish and dairy. 🚫 Ultra-processed foods, sugary drinks, and trans fats…
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πŸ«€ Heart transplantation is a life-saving treatment for end-stage heart failure, but donor hearts are scarce. πŸ” Donor selection is complex, involving factors like age, heart size, LV function, and comorbidities. 🌍 The U.S. is more conservative than Europe, with higher donor heart nonuse rates. βš™οΈ New tools like Predicted Heart Mass (PHM), Organ Care…
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πŸš‘ A rapid-fire guide to cardiogenic shock β€” from first suspicion to life-saving interventions. 🩺 ACC’s latest on Cardiogenic Shock: πŸ‘οΈ Early detection with SUSPECT CS πŸ’‰ First-line meds: norepinephrine & dobutamine πŸ› οΈ tMCS for refractory cases (Impella, VA-ECMO) πŸ₯ Transfer to Level 1 centers 🀝 Team-based care = better outcomes πŸ’‘ Act fast, save lives…
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πŸ§ͺ A randomized clinical trial in older adults (65+) found that Vitamin K2 (menaquinone-7, 180β€―ΞΌg/day) significantly reduced nocturnal leg cramps in terms of frequency, severity, and durationβ€”with no adverse effects reported. πŸŒ™πŸ¦΅πŸ’Š This safe (?), over-the-counter supplement may offer a simple, science-backed solution for painful nighttime crampsβ€”avoid…
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πŸ“Š Too much sitting hurts the heart. πŸ§β€β™‚οΈ Ajufo et al. (2024) tracked 89,530 people using accelerometers and found that πŸͺ‘ >10.6 hours/day of sitting sharply increases the risk of ❀️ heart failure, πŸ’” heart attacks, πŸ’“ AFib, and ⚰️ cardiovascular death. πŸƒ Even active people aren’t fully protected. πŸ” Replacing just 30 minutes of sitting with movementβ€”πŸ•Ί …
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πŸ§‘β€βš•οΈπŸ’” Young, Fit… Gone? Every year, thousands of seemingly healthy young adults suffer sudden cardiac arrest (SCA) outside the hospital. πŸ“‰ Only 9–16% survive to discharge β€” yet 90% of survivors leave with good brain function. πŸ” Many have hidden risk factors β€” hypertension, diabetes, even genetic arrhythmia syndromes like Brugada or Long QT. ⚑ Rapid…
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Siddhartha Gautama, known as the Buddha (β€œthe awakened one”), was a spiritual teacher who founded Buddhism in the 5th or 6th century BCE in South Asia. His core teachings include the Middle Way, the Four Noble Truths, and the Noble Eightfold Path, emphasizing mindfulness, ethics, and liberation from suffering.…
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🧬 Your mother’s X chromosome may shape how your brain ages. In female mice, when only the maternal X chromosome (Xm) is active, older animals show worse memory πŸ§ πŸ•³οΈ than those with random X-inactivation. This is due to imprinted genes β€” some only expressed from the paternal X (Xp) β€” which are silent when Xm dominates. πŸ§ πŸ’‘ Using CRISPR–Cas9, researche…
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πŸ”¬ Confounding, Clarity, and Causality Family-based biobanks 🧬 are the next frontier in genetic researchβ€”tackling bias 🧠, boosting causal inference 🎯, and revealing insights hidden in the noise of population studies 🌍. It’s not just about big dataβ€”it’s about better data πŸ‘¨β€πŸ‘©β€πŸ‘§β€πŸ‘¦.By MasterMedFacts LLC
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🧠 Brain Aging & Research Advances πŸ” Key Findings: β€’ Brain Age Gap (BAG): Difference between estimated and chronological brain age. β€’ 64 genes identified as influencing brain aging. β€’ 13 proteins in blood linked to accelerated/slowed brain aging. 🩺 Potential Interventions: β€’ 13 anti-aging drugs (e.g., Rapamycin, Dasatinib) show promise in slowing de…
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The blood-brain barrier (BBB) πŸ›‘οΈ protects the brain from harmful molecules but weakens with aging πŸ§“, leading to neuroinflammation πŸ”₯ and cognitive decline πŸ“‰. Mucins 🧬, slippery proteins in the glycocalyx πŸ—οΈ, help maintain BBB integrity 🧠. This study found that mucin loss 🚨 increases BBB permeability, allowing toxins to enter. Using gene therapy πŸ§ͺ, r…
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🧠 Migraine is a complex neurological disorder affecting 1 billion people worldwide. Historically misunderstood, it was once seen as a vascular or psychological issue but is now recognized as a brain network dysfunction involving the hypothalamus and limbic system. πŸ’Š Gepants and CGRP blockers have revolutionized treatment, though they only work for …
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Alcohol is a proven carcinogen 🚨, increasing the risk of at least 7 cancers (mouth, throat, breast, liver, etc.) πŸ¦ πŸ’€. Even small amounts (5g ethanol/day) raise cancer risk, with no safe threshold πŸ“ŠπŸš«. Similarly, exceeding 14 drinks/week (men) or 7 (women) raises CHD risk by up to 43% πŸ’”πŸ“ˆ. Past claims of heart benefits from moderate drinking are now be…
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Heraclitus (c. 500 BC), a pre-Socratic philosopher from Ephesus, is renowned for his doctrine of perpetual change and the unity of opposites, encapsulated in the phrase β€œEverything flows” and β€œNo man ever steps in the same river twice.” His concept of logos as the rational order of the universe influenced ancient and modern philosophy, including th…
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β˜• Coffee & Gut Microbiome 🦠 πŸ”¬ A multi-cohort study (N = 22,867) found a strong link between coffee consumption and the gut bacterium Lawsonibacter asaccharolyticus. πŸ§ͺ Metabolomics identified key coffee-derived metabolites like quinic acid, hippurate, and trigonelline. πŸ“Š Machine learning (AUC = 0.89) confirmed microbiome composition predicts coffee …
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πŸ”¬ Antioxidants & Health: Myths vs. Reality βŒπŸŠπŸ’Š Despite popular belief, vitamins C & E do not reduce the risk of cancer, heart disease, or chronic illness 🚫❀️. High doses of vitamin A increase the risk of hip fractures & prostate cancer ⚠️🦴, while vitamin E is linked to respiratory infections, prostate cancer, and even death 😷❌. However, a specific …
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πŸ”¬ Anemia & Folate: Key Insights 🩸 Anemia is primarily caused by iron deficiency in the U.S., especially in pregnancy (30% prevalence). πŸ“Š NHANES data shows high iron deficiency in young females (up to 77.5% at ferritin 45 mg/day may cause nausea & constipation. πŸ‘Ά Maternal iron status affects infant birth weight, and delayed cord clamping improves ne…
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Vitamin B12: Essential for Health 🩸🧠 Vitamin B12 is crucial for red blood cell formation, brain function, and DNA synthesis. Found in animal-based foods πŸ₯›πŸ³πŸŸ, those on vegan diets need fortified foods or supplements πŸ’Š. Deficiency can cause anemia, neurological issues, and cognitive decline ⚠️. High-risk groups include vegans, vegetarians, older adul…
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🧠 High-dose Vitamin D (100,000 IU biweekly) reduced disease activity in Clinically Isolated Syndrome (CIS) of MS πŸŒžπŸ“‰. Patients had fewer MRI lesions πŸ–₯️, longer time to disease activity ⏳, but no significant impact on relapses ❌. Well-tolerated with minimal side effects βš•οΈ, These findings support further research on Vitamin D as an MS therapy πŸ”¬πŸš€.…
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Vitamin D is essential for bone health 🦴, immune function πŸ›‘οΈ, and muscle strength πŸ‹οΈ. Deficiency is common and affects women πŸ‘©β€βš•οΈ, young adults πŸ§‘β€πŸŽ“, and non-Hispanic Black Americans. Main sources include sunlight β˜€οΈ, oily fish 🐟, eggs πŸ₯š, and fortified foods πŸ₯›. Recommended intake is 600-800 IU/day πŸ’Š. Studies show mixed results πŸ“Š, but it may help wit…
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πŸ”¬ BEAM-302 is a liver-targeting gene therapy using base editing to correct the PiZ mutation in Alpha-1 Antitrypsin Deficiency (AATD). 🧬 I t increases functional AAT 🫁 while reducing toxic Z-AAT, showing up to 78% reduction at the 60 mg dose. πŸ“Š The Phase 1/2 trial demonstrated dose-dependent efficacy, a well-tolerated safety profile, and no serious …
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Confucius (c. 551–479 BCE), a renowned Chinese philosopher and teacher, founded Confucianism, emphasizing morality, family loyalty, social harmony, and virtuous governance. His teachings, compiled in the Analects, profoundly influenced Chinese culture, ethics, and education.By MasterMedFacts LLC
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This study identifies the Median Raphe Nucleus (MRN) 🧠 as a behavioral switchboard πŸ”„, regulating perseverance πŸ›‘, exploration πŸš€, and disengagement ❌ through distinct neuron types. GABAergic neurons 🟒 promote perseverance, Glutamatergic neurons πŸ”΅ drive exploration, and Serotonergic neurons 🟠 maintain engagement. Using optogenetics πŸ’‘, fiber photometry…
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πŸ”¬ Study Overview: A meta-analysis comparing alternative LDL cholesterol-lowering strategies (moderate-intensity statins + ezetimibe) vs high-intensity statins in patients with ASCVD. πŸ“Š Key Findings: βœ… No significant difference in 3-year cardiovascular events (7.5% vs 7.7%) πŸ“‰ Lower LDL cholesterol in the alternative strategy (64.8 vs 68.5 mg/dL) 🩸 R…
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🦴 USPSTF Osteoporosis Screening Summary πŸ“‹ πŸ” Why? Prevent fractures, disability, and mortality. πŸ‘©β€βš•οΈ Who? Women 65+ βœ…, at-risk postmenopausal women βœ…, men ❌ (insufficient evidence). 🩻 How? DXA scan (bone density test) is the gold standard. ⚠️ Risk Factors: Age, low weight, family history, smoking, alcohol, medications. βœ… Benefits: Reduces fracture r…
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πŸ«€ Cardiac CT Calcium Score: Key Insights πŸ”¬πŸ“Š πŸ” What is CAC? βœ… Measures calcified plaque in coronary arteries via cardiac CT πŸ“Έ βœ… Higher CAC = Higher cardiovascular risk ⚠️ βœ… Agatston Score: 0 (None) β†’ >400 (Severe Atherosclerosis) πŸ“Š Clinical Impact: βœ… Strong predictor of ASCVD events (MI, stroke, CHD death) πŸ“‰ βœ… MESA Study: CAC >300 β†’ 10-year CHD risk…
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Tirzepatide & Weight Maintenance πŸ’ŠπŸ“‰ A phase 3 clinical trial (SURMOUNT-4) showed that continued use of tirzepatide helps maintain weight loss in adults with obesity. Participants on tirzepatide lost an extra 5.5%, while those on placebo regained 14%. βœ… 89.5% maintained at least 80% of their weight loss, compared to 16.6% on placebo. Common side eff…
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πŸ«€ CAUGHT-CAD Trial Summary πŸ”¬ πŸ” Objective: Investigated whether CAC scoring combined with a prevention strategy slows plaque progression in intermediate-risk patients with a family history of CAD. πŸ“Š Key Findings: βœ… LDL Reduction: -51 mg/dL (CAC group) vs. -2 mg/dL (Usual Care) πŸ“‰ βœ… Slower Plaque Progression: +15.4 mmΒ³ vs. +24.9 mmΒ³ (p=0.009) πŸ₯ βœ… Less…
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🩸 Bleeding & Cancer Risk in AF Patients on Anticoagulants πŸ₯ πŸ”Ž Study Goal: Investigate the link between bleeding after anticoagulation for atrial fibrillation (AF) and new cancer diagnoses. πŸ“Š Findings: βœ… Bleeding 4X increases the risk of cancer diagnosis (HR: 4.0). πŸ”΄ GI Bleeding β†’ 15.4X risk of GI Cancer 🟠 GU Bleeding β†’ 11.8X risk of GU Cancer 🟑 Res…
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Laozi, a legendary Chinese philosopher and author of the Tao Te Ching, is regarded as the founder of Taoism. His teachings emphasize living in harmony with the Tao (the Way), advocating simplicity, humility, and wu wei (effortless action) for a balanced life.By MasterMedFacts LLC
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This study explores how environmental exposures (exposome) 🌍 and genetics 🧬 contribute to aging ⏳ and mortality ⚰️. Using UK Biobank data πŸ“Š, researchers found that the exposome explains 17% of mortality risk, while genetics accounts for only 2%. Smoking 🚬, socioeconomic status πŸ’°, and physical activity πŸƒβ€β™‚οΈ are major environmental influences, wherea…
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