Created by Tinkercast in collaboration with The Pop Ups, Flip and Mozi is an intergalactic musical journey that brings conservation into the conversation for kids and their grown-ups. Available every Thursday or listen ad-free and 1 week early and ad-free on Wondery+, Wondery+ Kids on Apple Podcasts, or on Amazon Music with a Prime membership or Amazon Music Unlimited subscription. Visit flipandmozi.com for conversation starters, book lists and activities to keep the wow rolling long after t ...
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2019[MOZI]~ βJustice League Dark: Apokolips War β TELJES FILM VIDEA HD (INDAVIDEO) MAGYARUL
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A SΓΆtΓ©t IgazsΓ‘g LigΓ‘ja: Apokoliszi hΓ‘borΓΊ LetΓΆltΓ©s >>> https://bit.ly/2STysih Streaming>>>> https://tinyurl.com/y9gzoq3w
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Mozi ~ (Peter Rabit 2) NyΓΊl PΓ©ter 2. - NyΓΊlcipΕ Online 2020 Teljes Filmek Videa HD (Film Magyarul)
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PLAY : https://bit.ly/39kyvsE
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βGot Knowledge Docβ Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Eac ...
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Az AlkotΓ‘s Γtja 2007-ben jelent meg a Tilos RΓ‘diΓ³ szΓΆvetΓ©ben. A rΓ©szvΓ©teli alapon szervezΕdΕ adΓ‘sfolyam, azΓ³ta folyamatosan, heti egy alkalommal jelentkezik, Γ©s figyelem Γ©s reflexiΓ³-befektetΓ©skΓ©nt mΕ±kΓΆdik. Az Γ‘ltalΓ‘ban egyetlen vendΓ©gre Γ©pΓΌlΕ, hallgatΓ³i hozzΓ‘szΓ³lΓ‘sokra nyitott adΓ‘s, egyszersmind diszkurzΓv platformot is nyΓΊjt. Az eredeti cΓ©loknak megfelelΕen a kortΓ‘rsmΕ±vΓ©szeti szcΓ©na szereplΕit hΓvjuk el aktuΓ‘lis tΓ©mΓ‘krΓ³l beszΓ©lgetni. Az eddigi kb. 500+ adΓ‘sban kb. 400 vendΓ©g szerepelt, jΓ³nΓ© ...
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HΓ©t Γ©vvel felesΓ©ge halΓ‘la utΓ‘n Dr. John Dolittle (Downey), a viktoriΓ‘nus Anglia hΓres orvosa Γ©s Γ‘llatorvosa kastΓ©lya falai kΓΆzΓ© zΓ‘rkΓ³zva Γ©l egy Γ‘llatsereglettel.
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(nΓ©zd)!videa Bad Boys β MindΓΆrΓΆkkΓ© rosszfiΓΊk Teljes Film HD ( Magrayul ) online.4k
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Nezd HD >+> https://bit.ly/3ahMOjm Β© Szerintetek: 16+ | 113" | Premier (HU): 2020.01.16. | InterCom
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Dr. RR Baligaβs Philosophical Discourses: Mozi (China, c. 470β391 BCE) β Founder of Mohism
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3:48Mozi, a prominent Chinese philosopher during the Warring States period, founded Mohism, a school of thought emphasizing universal love, meritocracy, anti-war principles, and consequentialist ethics. He advocated for frugality, social welfare, and pragmatic governance guided by Heavenβs will.By MasterMedFacts LLC
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adΓ‘s archΓvumBy Tilos RΓ‘diΓ³
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βSalted Truths: π§β€οΈβοΈ Rethinking Sodium for Heart and Kidney Healthβ
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2:04Not all salts are created equal! π§ Sodium chloride raises blood pressure and harms the heart π, while sodium bicarbonate may protect kidneys and improve outcomes in CKD/HF patients π‘οΈπ«. Chloride channels (CLICs) play a hidden but vital role in heart health πβ€οΈ. We need large RCTs π§ͺπ to guide smarter, personalized salt strategies for better cardiovaβ¦
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π Oral Semaglutide Enters the Arena β The SOUL Trial
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3:11The SOUL trial π§ͺ showed that oral semaglutide π significantly reduced major cardiovascular events β€οΈ (MACE) in people with type 2 diabetes π©Έ and ASCVD/CKD π. Over ~4 years, it cut heart attacks π₯, lowered HbA1c π, reduced weight βοΈ, and inflammation π₯ β all with a once-daily pill ποΈ and no rise in serious side effects.β¦
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Coronary Artery Disease: Fix the Future, Not Just the Flow ππ«π οΈβ
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2:14The Lancet Commission calls for a shift from focusing on late-stage ischaemia to targeting early atherosclerosis (ACAD) π«π. By detecting and treating plaque early, we can prevent heart attacks, reduce deaths, and promote lifelong heart health πβ€οΈπ‘.By MasterMedFacts LLC
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π§ π βShots, Shingles, and Sharp Minds: The Brain-Boosting Power of a Vaccine
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2:16π A natural experiment in Wales showed that the shingles vaccine (Zostavax) reduced dementia risk by 20% over 7 years. π§ The study used a clever birthdate cutoff to mimic randomization and avoid confounding. π©βπ¬ Women benefited more, suggesting immune or viral mechanisms beyond shingles prevention. π Findings offer hope for low-cost, brain-protectiβ¦
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πΆββοΈπ Giant Strides with Weekly Semaglutide Jabs!
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3:04πΆββοΈ The STRIDE trial tested semaglutide in patients with PAD and type 2 diabetes. π Weekly injections for 52 weeks improved walking distance, pain-free mobility, and quality of life. π Results showed significant gains vs placebo, with low adverse events. π Semaglutide may offer a new stride forward in treating functional limitations in PAD.β¦
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Microbial Enzymes, Human Time: The Xenotopic Way to Live Longer
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3:11𧬠Xenotopic synthetic biology explores using enzymes from microbes (like bacteria and yeast) to reprogram human metabolism and delay aging. π These βborrowedβ enzymes target amino acid levels, mitochondrial function, and redox balance to boost healthspan and fight age-related diseases. π¦ From methioninase to NDI1 and AOX, these tools may turn microβ¦
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adΓ‘s archΓvumBy Tilos RΓ‘diΓ³
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πββοΈπ Heartbreak at the Finish Line: Racing Against Cardiac Arrest β‘π
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2:55πββοΈπ In a study of 29 million race finishers (2010β2023), cardiac arrest rates during marathons and half-marathons stayed steady, but deaths dropped by half. π§ β‘ Rapid CPR and AED use saved lives, with coronary artery diseaseβnot hypertrophic cardiomyopathyβbeing the top culprit. π«πBy MasterMedFacts LLC
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πββοΈπ§ π‘ Move. Spark. Remember: The Brain Boost of Exercise
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2:16π§ Exercise is a powerful neuroprotective toolβit boosts memory, preserves brain volume, and reduces dementia risk. πͺ Through exerkines like BDNF and irisin, it sparks neurogenesis, clears inflammation, and enhances brain plasticity. π± It also nurtures your gut microbiome and rewires your genes, making movement medicine for the mind.β¦
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Dr. RR Baligaβs Philosophical Discourses: Socrates (Greece, 469β399 BCE) β Classical Philosopher
2:51
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2:51A brief overview of Socrates, the classical Greek philosopher widely regarded as the founder of Western philosophy. Known for his Socratic method of questioning, he profoundly influenced ethical thought, epistemology, and later philosophical traditions.By MasterMedFacts LLC
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ποΈ βπ₯ Plants, π½οΈ Plates, and π€ Paradoxes: Decoding Diets for a Long Lifeβ
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5:26π In this episode, we unpack a 30-year study on how diet influences aging. π₯ AHEI, DASH, and Mediterranean diets boost your odds of healthy agingβby as much as 86%! β οΈ But not all plant-based diets are equal: hPDI underwhelms, likely due to excluding protective animal foods like fish and dairy. π« Ultra-processed foods, sugary drinks, and trans fatsβ¦
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Hearts on the Line: Choosing Wisely, Saving Lives β€οΈπ«
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5:19π« Heart transplantation is a life-saving treatment for end-stage heart failure, but donor hearts are scarce. π Donor selection is complex, involving factors like age, heart size, LV function, and comorbidities. π The U.S. is more conservative than Europe, with higher donor heart nonuse rates. βοΈ New tools like Predicted Heart Mass (PHM), Organ Careβ¦
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β‘ Cardiogenic Shock Strategy: ποΈ Spot It β’ β Stop It β’ π Save Lives
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5:58π A rapid-fire guide to cardiogenic shock β from first suspicion to life-saving interventions. π©Ί ACCβs latest on Cardiogenic Shock: ποΈ Early detection with SUSPECT CS π First-line meds: norepinephrine & dobutamine π οΈ tMCS for refractory cases (Impella, VA-ECMO) π₯ Transfer to Level 1 centers π€ Team-based care = better outcomes π‘ Act fast, save livesβ¦
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Leg Cramps at Night π€, Relief in Sight π, Powered by Vitamin K2 π
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3:18π§ͺ A randomized clinical trial in older adults (65+) found that Vitamin K2 (menaquinone-7, 180β―ΞΌg/day) significantly reduced nocturnal leg cramps in terms of frequency, severity, and durationβwith no adverse effects reported. ππ¦΅π This safe (?), over-the-counter supplement may offer a simple, science-backed solution for painful nighttime crampsβavoidβ¦
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adΓ‘s archΓvumBy Tilos RΓ‘diΓ³
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πͺ Sit Less. πββοΈ Move More. β€οΈ Live Longer
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5:15π Too much sitting hurts the heart. π§ββοΈ Ajufo et al. (2024) tracked 89,530 people using accelerometers and found that πͺ >10.6 hours/day of sitting sharply increases the risk of β€οΈ heart failure, π heart attacks, π AFib, and β°οΈ cardiovascular death. π Even active people arenβt fully protected. π Replacing just 30 minutes of sitting with movementβπΊ β¦
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Young, Fit⦠Gone? The Hidden Dangers of Cardiac Arrest
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6:08π§ββοΈπ Young, Fitβ¦ Gone? Every year, thousands of seemingly healthy young adults suffer sudden cardiac arrest (SCA) outside the hospital. π Only 9β16% survive to discharge β yet 90% of survivors leave with good brain function. π Many have hidden risk factors β hypertension, diabetes, even genetic arrhythmia syndromes like Brugada or Long QT. β‘ Rapidβ¦
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Dr. RR Baligaβs Philosophical Discourses: Gautama Buddha (India, c. 563β483 BCE) β Founder of Buddhism
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3:13Siddhartha Gautama, known as the Buddha (βthe awakened oneβ), was a spiritual teacher who founded Buddhism in the 5th or 6th century BCE in South Asia. His core teachings include the Middle Way, the Four Noble Truths, and the Noble Eightfold Path, emphasizing mindfulness, ethics, and liberation from suffering.β¦
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π₯ Sizzle, π Swap, πͺ Survive: Oils That Heal, Fats That Harm
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3:22β’Olive. Canola. Soybean. β’Not just flavorβtheyβre lifelines. π± β’Every 10g a day drops mortality by 16%. β’They donβt just cook foodβthey cook up longevity? π₯β³By MasterMedFacts LLC
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𧬠Your motherβs X chromosome may shape how your brain ages. In female mice, when only the maternal X chromosome (Xm) is active, older animals show worse memory π§ π³οΈ than those with random X-inactivation. This is due to imprinted genes β some only expressed from the paternal X (Xp) β which are silent when Xm dominates. π§ π‘ Using CRISPRβCas9, researcheβ¦
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Genes, Families, and Households: Rethinking Biobank Science
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6:04π¬ Confounding, Clarity, and Causality Family-based biobanks 𧬠are the next frontier in genetic researchβtackling bias π§ , boosting causal inference π―, and revealing insights hidden in the noise of population studies π. Itβs not just about big dataβitβs about better data π¨βπ©βπ§βπ¦.By MasterMedFacts LLC
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π§ Brain aging decoded! Scientists identify 64 genes & 13 blood proteins linked to aging.
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3:11π§ Brain Aging & Research Advances π Key Findings: β’ Brain Age Gap (BAG): Difference between estimated and chronological brain age. β’ 64 genes identified as influencing brain aging. β’ 13 proteins in blood linked to accelerated/slowed brain aging. π©Ί Potential Interventions: β’ 13 anti-aging drugs (e.g., Rapamycin, Dasatinib) show promise in slowing deβ¦
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Brain Slime to the Rescue! π§ π‘οΈ How Mucins Protect Against Aging & Cognitive Decline π
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4:58The blood-brain barrier (BBB) π‘οΈ protects the brain from harmful molecules but weakens with aging π§, leading to neuroinflammation π₯ and cognitive decline π. Mucins π§¬, slippery proteins in the glycocalyx ποΈ, help maintain BBB integrity π§ . This study found that mucin loss π¨ increases BBB permeability, allowing toxins to enter. Using gene therapy π§ͺ, rβ¦
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adΓ‘s archΓvumBy Tilos RΓ‘diΓ³
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π One Billion Suffer: Decoding Migraine π§ ππ
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3:58π§ Migraine is a complex neurological disorder affecting 1 billion people worldwide. Historically misunderstood, it was once seen as a vascular or psychological issue but is now recognized as a brain network dysfunction involving the hypothalamus and limbic system. π Gepants and CGRP blockers have revolutionized treatment, though they only work for β¦
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βAlcohol: A Double-Edged Sword βοΈπ· β Cancer, Heart Risks & What You Need to Know!β
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3:38Alcohol is a proven carcinogen π¨, increasing the risk of at least 7 cancers (mouth, throat, breast, liver, etc.) π¦ π. Even small amounts (5g ethanol/day) raise cancer risk, with no safe threshold ππ«. Similarly, exceeding 14 drinks/week (men) or 7 (women) raises CHD risk by up to 43% ππ. Past claims of heart benefits from moderate drinking are now beβ¦
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Dr. RR Baligaβs Philosophical Discourses: Heraclitus (Greece, c. 535β475 BCE) β Pre-Socratic Philosopher
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3:29Heraclitus (c. 500 BC), a pre-Socratic philosopher from Ephesus, is renowned for his doctrine of perpetual change and the unity of opposites, encapsulated in the phrase βEverything flowsβ and βNo man ever steps in the same river twice.β His concept of logos as the rational order of the universe influenced ancient and modern philosophy, including thβ¦
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β Brewed for Your Gut? π¬ Coffee, Microbiome, & Metabolic Magic! π¦ β¨
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2:34β Coffee & Gut Microbiome π¦ π¬ A multi-cohort study (N = 22,867) found a strong link between coffee consumption and the gut bacterium Lawsonibacter asaccharolyticus. π§ͺ Metabolomics identified key coffee-derived metabolites like quinic acid, hippurate, and trigonelline. π Machine learning (AUC = 0.89) confirmed microbiome composition predicts coffee β¦
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Move over, Bionic Manβthis titanium heart π«βοΈ just made science fiction a reality! ππ
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2:22By MasterMedFacts LLC
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π¬ Antioxidants & Health: The Science Behind the Hype ββ€οΈ
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2:39π¬ Antioxidants & Health: Myths vs. Reality βππ Despite popular belief, vitamins C & E do not reduce the risk of cancer, heart disease, or chronic illness π«β€οΈ. High doses of vitamin A increase the risk of hip fractures & prostate cancer β οΈπ¦΄, while vitamin E is linked to respiratory infections, prostate cancer, and even death π·β. However, a specific β¦
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βπ©Έ Iron & Folate: The Power of Nutrients for a Healthy Life πͺπβ
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3:34π¬ Anemia & Folate: Key Insights π©Έ Anemia is primarily caused by iron deficiency in the U.S., especially in pregnancy (30% prevalence). π NHANES data shows high iron deficiency in young females (up to 77.5% at ferritin 45 mg/day may cause nausea & constipation. πΆ Maternal iron status affects infant birth weight, and delayed cord clamping improves neβ¦
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adΓ‘s archΓvumBy Tilos RΓ‘diΓ³
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Vitamin B12: The Brain & Blood Booster? π©Έπ§ πͺ
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2:54Vitamin B12: Essential for Health π©Έπ§ Vitamin B12 is crucial for red blood cell formation, brain function, and DNA synthesis. Found in animal-based foods π₯π³π, those on vegan diets need fortified foods or supplements π. Deficiency can cause anemia, neurological issues, and cognitive decline β οΈ. High-risk groups include vegans, vegetarians, older adulβ¦
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π₯ Vitamin D & Multiple Sclerosis: Defending the Nervous System π§ π‘οΈ
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3:03π§ High-dose Vitamin D (100,000 IU biweekly) reduced disease activity in Clinically Isolated Syndrome (CIS) of MS ππ. Patients had fewer MRI lesions π₯οΈ, longer time to disease activity β³, but no significant impact on relapses β. Well-tolerated with minimal side effects βοΈ, These findings support further research on Vitamin D as an MS therapy π¬π.β¦
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βοΈ Vitamin D: The Sunshine Nutrient for Strong Bones & Immunity? π¦΄π‘οΈβ
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5:59Vitamin D is essential for bone health π¦΄, immune function π‘οΈ, and muscle strength ποΈ. Deficiency is common and affects women π©ββοΈ, young adults π§βπ, and non-Hispanic Black Americans. Main sources include sunlight βοΈ, oily fish π, eggs π₯, and fortified foods π₯. Recommended intake is 600-800 IU/day π. Studies show mixed results π, but it may help witβ¦
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BEAM-302: Rewriting Genes, Restoring Health β A Breakthrough in AATD Therapy! π¬π
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3:30π¬ BEAM-302 is a liver-targeting gene therapy using base editing to correct the PiZ mutation in Alpha-1 Antitrypsin Deficiency (AATD). 𧬠I t increases functional AAT π« while reducing toxic Z-AAT, showing up to 78% reduction at the 60 mg dose. π The Phase 1/2 trial demonstrated dose-dependent efficacy, a well-tolerated safety profile, and no serious β¦
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Dr. RR Baligaβs Philosophical Discourses: Confucius (China, 551β479 BCE) β Founder of Confucianism
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4:02Confucius (c. 551β479 BCE), a renowned Chinese philosopher and teacher, founded Confucianism, emphasizing morality, family loyalty, social harmony, and virtuous governance. His teachings, compiled in the Analects, profoundly influenced Chinese culture, ethics, and education.By MasterMedFacts LLC
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βThe Brainβs Switchboard π: How MRN Controls Perseverance π, Exploration π & Disengagement ββ
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4:46This study identifies the Median Raphe Nucleus (MRN) π§ as a behavioral switchboard π, regulating perseverance π, exploration π, and disengagement β through distinct neuron types. GABAergic neurons π’ promote perseverance, Glutamatergic neurons π΅ drive exploration, and Serotonergic neurons π maintain engagement. Using optogenetics π‘, fiber photometryβ¦
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βπ High Intensity Statins vs Smart Alternatives: A Heart-Healthy Showdown! β€οΈπβ
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1:54π¬ Study Overview: A meta-analysis comparing alternative LDL cholesterol-lowering strategies (moderate-intensity statins + ezetimibe) vs high-intensity statins in patients with ASCVD. π Key Findings: β
No significant difference in 3-year cardiovascular events (7.5% vs 7.7%) π Lower LDL cholesterol in the alternative strategy (64.8 vs 68.5 mg/dL) π©Έ Rβ¦
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βStronger Bones, Fewer Fractures! π¦΄π USPSTF Osteoporosis Screening Guideβ
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2:22𦴠USPSTF Osteoporosis Screening Summary π π Why? Prevent fractures, disability, and mortality. π©ββοΈ Who? Women 65+ β
, at-risk postmenopausal women β
, men β (insufficient evidence). π©» How? DXA scan (bone density test) is the gold standard. β οΈ Risk Factors: Age, low weight, family history, smoking, alcohol, medications. β
Benefits: Reduces fracture rβ¦
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βπ« Cracking the Calcium Code: How CAC Scoring Transforms Cardiovascular Risk Assessment! π¬πβ
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6:22π« Cardiac CT Calcium Score: Key Insights π¬π π What is CAC? β
Measures calcified plaque in coronary arteries via cardiac CT πΈ β
Higher CAC = Higher cardiovascular risk β οΈ β
Agatston Score: 0 (None) β >400 (Severe Atherosclerosis) π Clinical Impact: β
Strong predictor of ASCVD events (MI, stroke, CHD death) π β
MESA Study: CAC >300 β 10-year CHD riskβ¦
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Tirzepatide: Game Changer for Weight Maintenance ππ
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2:46Tirzepatide & Weight Maintenance ππ A phase 3 clinical trial (SURMOUNT-4) showed that continued use of tirzepatide helps maintain weight loss in adults with obesity. Participants on tirzepatide lost an extra 5.5%, while those on placebo regained 14%. β
89.5% maintained at least 80% of their weight loss, compared to 16.6% on placebo. Common side effβ¦
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adΓ‘s archΓvumBy Tilos RΓ‘diΓ³
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βπ« Stop Plaque in Its Tracks! How CAC Scoring Transforms Heart Health πβ
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3:56π« CAUGHT-CAD Trial Summary π¬ π Objective: Investigated whether CAC scoring combined with a prevention strategy slows plaque progression in intermediate-risk patients with a family history of CAD. π Key Findings: β
LDL Reduction: -51 mg/dL (CAC group) vs. -2 mg/dL (Usual Care) π β
Slower Plaque Progression: +15.4 mmΒ³ vs. +24.9 mmΒ³ (p=0.009) π₯ β
Lessβ¦
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π©Έ Bleeding After Anticoagulation: A Hidden Cancer Warning? ππ¨
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1:51π©Έ Bleeding & Cancer Risk in AF Patients on Anticoagulants π₯ π Study Goal: Investigate the link between bleeding after anticoagulation for atrial fibrillation (AF) and new cancer diagnoses. π Findings: β
Bleeding 4X increases the risk of cancer diagnosis (HR: 4.0). π΄ GI Bleeding β 15.4X risk of GI Cancer π GU Bleeding β 11.8X risk of GU Cancer π‘ Resβ¦
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The RENOVE trial compared reduced-dose versus full-dose DOACs for extended venous thromboembolism VTE treatment in high-risk patients. While the reduced dose cut major bleeding risk by 39% π¨, it did not meet non-inferiority criteria for preventing VTE recurrence π.By MasterMedFacts LLC
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Dr. RR Baligaβs Philosophical Discourses: Laozi (China, c. 6th Century BCE) β Founder of Taoism
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3:00Laozi, a legendary Chinese philosopher and author of the Tao Te Ching, is regarded as the founder of Taoism. His teachings emphasize living in harmony with the Tao (the Way), advocating simplicity, humility, and wu wei (effortless action) for a balanced life.By MasterMedFacts LLC
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β𧬠vs. π: How Genetics and the Exposome Shape Aging & Mortality β³β°οΈβ
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2:50This study explores how environmental exposures (exposome) π and genetics 𧬠contribute to aging β³ and mortality β°οΈ. Using UK Biobank data π, researchers found that the exposome explains 17% of mortality risk, while genetics accounts for only 2%. Smoking π¬, socioeconomic status π°, and physical activity πββοΈ are major environmental influences, whereaβ¦
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