Welcome to The Pharma Podcast - Insights from industry experts and business leaders about important and current topics in Canadian Pharma, Biotech and Medtech.
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On Happy Sad Confused, Josh Horowitz gets nerdy and intimate with the biggest movie stars and filmmakers on the planet. Each and every week, you’ll hear in-depth, career-spanning conversations with everyone from Samuel L. Jackson and Scarlett Johansson to Christopher Nolan and Quentin Tarantino. If you’ve ever wanted to know what it was like to get casual with A-listers like Tom Hiddleston or Kristen Stewart (all HSC regulars), then come on in and join Josh on Happy Sad Confused.
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Bill Maher rewrites the rules of podcasting the way he did in television in this series of one on one, hour long conversations with a wide variety of unexpected guests in the undisclosed location called Club Random. There’s a whole big world out there that isn’t about politics and Bill and his guests talk about all of it. For advertising opportunities please email [email protected] We wanna make the podcast even better, help us learn how we can: https://bit.ly/2EcYbu4 Privac ...
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Bitcoin pioneer Charlie Shrem peels back the layers on the lives and backgrounds of the world's most impactful innovators. Centering around intimate narratives, Shrem uncovers a detailed, previously unspoken story of the genesis and evolution of bitcoin, cryptocurrency, artificial intelligence, and the web3 movements. Join Shrem as he journeys through the uncharted territories of tech revolutions, revealing the human side of the stories that shaped the digital world we live in today.
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Actor, comedian, and Hollywood California native Brian Lally explores the lives of his guests and shares his experiences living and working in Hollywood as an actor and acting teacher.
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In an exclusive and unfiltered conversation, Bill Maher sits down with legendary musician Billy Joel for a rare long-form interview about life, legacy, and the making of his new HBO documentary, Billy Joel: And So It Goes. From the early days playing Long Island bars to selling out Madison Square Garden for decades, Billy reflects on the stories be…
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James Gunn, Vol. III (SUPERMAN Spoiler Special)
58:00
58:00
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58:00James Gunn's SUPERMAN is out and it's time to talk spoilers! In this wide-ranging chat, Gunn talks everything from casting and cut scenes to the future of Superman and the entire DCU. Check out the Happy Sad Confused patreon here…
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In the latest Club Random, Bill Maher goes toe-to-toe with actor-activist John Leguizamo in a rapid-fire conversation that jumps from the Knicks firing Tom Thibodeau to the eternal New York vs. L.A. debate. They dive into Latino representation in Hollywood and Leguizamo’s MSNBC docuseries "Leguizamo Does America," while trading war stories about aw…
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Madelyn Cline knows a change is coming as she starts shooting the final season of OUTER BANKS. But before she mourns that end she's celebrating her horror debut in I KNOW WHAT YOU DID LAST SUMMER, working with Johnny Depp, and more. Check out the Happy Sad Confused patreon h…
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Whitney Cummings drops by Club Random and things get weirdly hilarious in the best way. What starts as a wild gift quickly spirals into an uncensored dive into loneliness, AI, and the strange ways we seek connection. Bill and Whitney riff on everything from UFOs and conspiracy theories to the creeping presence of tech in our lives — and who’s reall…
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Bill Maher sits down with Odell Beckham Jr. for a wide-ranging conversation on everything from his iconic Giants catch to navigating injuries and the intensity of being in the spotlight. Odell opens up about the coaches and quarterbacks he respects, teases a possible return to the field, and reflects on the values of humility, fatherhood, teamwork,…
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Yes, Matthew Goode is as charming as you'd expect. Matthew joins Josh to chat about his re-teaming with Scott Frank in the critically acclaimed DEPT. Q, a disastrous James Bond meeting, his early experiences on CHASING LIBERTY, WATCHMEN, and much more! Check out the Happy Sad…
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Bill Maher welcomes actor Esai Morales for a rapid-fire hangout that jumps from tequila and raw-food fitness to fatherhood and playing the villain in Mission: Impossible – The Final Reckoning. They swap Pacino impressions, riff on devil lore and dating, then spiral into AI and conspiracy theories. Subscribe to the Club Random YouTube channel: https…
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When Sam Rockwell shows up good things happen. From indies to blockbusters to his latest instantly iconic surprise turn in THE WHITE LOTUS, he's a true chameleon and an actor's actor. Sam joins Josh to chat memorable monologues, his favorite actors, why Philip Seymour Hoffman was such an inspiration, and more. Check out the …
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28 YEARS LATER with Jodie Comer, Aaron Taylor-Johnson, & Danny Boyle
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53:14
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53:14It hasn't quite been 28 years but it's been a long time since 28 DAYS LATER. Now at long last director Danny Boyle is back. He joins Josh along with his 28 YEARS LATER stars Jodie Comer and Aaron Taylor-Johnson for this sneak peek at the long-awaited sequel to the horror classic. Recorded live at the 92nd Street Y. Check out the …
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BATMAN BEGINS 20th Anniversary special with David Goyer
50:23
50:23
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50:23We're celebrating 20 years since the launch of the Dark Knight trilogy with BATMAN BEGINS co-writer David Goyer! It's a deep dive into everything that made the movie special and changed the pop culture landscape forever! Check out the Happy Sad Confused patreon here…
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Sean Penn returns to Club Random for another wild ride with Bill Maher. From kissing James Franco in Milk to drone warfare in Ukraine, the conversation covers it all, politics, war, Hollywood, and even AI going rogue. Sean opens up about his documentary Superpower, Putin’s ambitions, America’s contradictions, and what it means to live fully in a br…
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Bitcoin as Pristine Collateral: Risk Redefined. @PeoplesReserve with @CJKonstantinos
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20:31
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20:31During the darkest days of the last bear market, 5 years ago, I met my friend and guest @CJKonstantinos at The Green Flash in Florida. This guy is the definition of OG by doubling down and starting @peoplesreserve. He's creating Bitcoin-backed financial products that are reshaping the way we think about money. Tomorrow we are both speaking at Bitco…
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One of the all time greats, Gary Oldman, returns for another masterclass discussion of acting, Hogwarts houses, and TIPTOES. Plus SLOW HORSES, DRACULA, and so much more! #happysadconfused #joshhorowitz #garyoldman #slowhorses Check out the Happy Sad Confused patreon here…
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Bush frontman Gavin Rossdale drops by Club Random to chat with Bill Maher about his new album “I Beat Loneliness,” the craft of songwriting, touring life, dad duties, aging like a rock star, mental health, religion, AI paranoia - and yes, a little life advice from David Bowie himself. Don’t forget to subscribe to the podcast for free wherever you'r…
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From Bitcoin to Boat Storage: Joey Rosati on Diversifying Investments
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34:26
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34:26I've gotten to know Joey Rosati (@rosaticorp) over the last 3 years working alonside hime in the VC trenches of Druid Ventures. Let me tell you, the VC world is a funny place and there are gems if you know where to find them. Joey is one of them. He knows that behind every successful business, it's all about people. In today's epic episode, Joey jo…
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Of course Tom Hiddleston is back! His latest film, THE LIFE OF CHUCK, is earning rave reviews so the man himself is here to talk about it, plus his return as Loki, his Everest adventure, Much Ado About Nothing, and what his favorite project in his career is. Check out the Happy Sa…
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One of the most versatile and fascinating actors of the last 30 years joins Josh on the podcast this week. Benicio Del Toro takes centerstage in a new Wes Anderson film and is here to talk about it, not to mention his experience making THE USUAL SUSPECTS, SICARIO, and much more. UPCOMING EVENTS Gary Oldman in LA 6/3 -- tickets here C…
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David Mamet and Bill Maher cover a lot of ground this spirted conversation, discussing Mamet’s recent film Henry Johnson, his upcoming projects including a novel on education and a film about Abraham Lincoln, the 2020 election, media bias, foreign interference in U.S. elections, Trump’s leadership style, gender policies in sports, the state of Cali…
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HOUSE OF THE DRAGON (Matt Smith, Emma D'Arcy, Olivia Cooke, Fabien Frankel, Tom Glynn-Carney & more)
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1:02:19The HOUSE OF THE DRAGON cast (Matt Smith, Emma D'Arcy, Olivia Cooke, Fabien Frankel, Tom Glynn-Carney, Steve Toussaint, and Ewan Mitchell) gathers (along with Ryan Condal and Sara Hess) to talk about key relationships, creative challenges, and look ahead to season 3. UPCOMING EVENTS 28 YEARS LATER Q&A with Jodie Comer, Aaron Taylor-Johnson, & Danny…
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It may or may not be the FINAL reckoning for the MISSION: IMPOSSIBLE franchise but writer/director Christopher McQuarrie is here to talk about the unusual way they make these films, plus give some teases about the future of TOP GUN and DAYS OF THUNDER, and a glimpse at the Superman sequel he wanted to do. UPCOMING EVENTS 28 YEARS LATER Q&A with Jod…
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Bill Maher sits down with Tim Pool host of The Culture War Podcast for a conversation on health, aging and the bizarre wellness trends sweeping the culture to the impact of media polarization, the manipulation of public perception, generational divides in politics, the rise of wokeness, and the cultural shifts defining Gen Z and Gen Alpha, the chal…
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He's just coming off a Tony win and he just might be in line for another! Jonathan Groff takes center stage on this episode to talk about playing Bobby Darin in JUST IN TIME, how SPRING AWAKENING changed his life, why he was so well suited for MINDHUNTER, and what he considers the best movie musicals of all time! UPCOMING EVENTS 28 YEARS LATER Q&A …
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How do you make the most celebrated STAR WARS story in decades without so much as a jedi in sight? You hire Tony Gilroy. The filmmaker behind MICHAEL CLAYTON and THE BOURNE LEGACY joins Josh to talk about his unlikely journey to ANDOR. Recorded at the 92nd Street Y. UPCOMING EVENTS 28 YEARS LATER Q&A with Jodie Comer, Aaron Taylor-Johnson, & Danny …
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On this episode, Bill sits down with fitness icon, wellness entrepreneur and straight-talking firebrand Jillian Michaels. Bill and Jillian settle in for a free-wheeling chat that drifts from lighthearted ribbing to debates about public health, politics, and pop culture. One minute they’re laughing about early-morning phone alerts or swapping travel…
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Sure, Alexander Skarsgard can be the leading man of your dreams but what he really wants to do is play a socially awkward android. And that's what he's doing in MURDERBOT, his new Apple series. He joins Josh at this live taping at the 92nd Street Y to discuss his journey from TRUE BLOOD to BIG LITTLE LIES to THE NORTHMAN to here, plus why he's more…
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John Boyega is one of us. Sure he's a STAR WARS star but he's also an unapologetic fanboy. He brings his enthusiasm to his chat with Josh taped in front of a live audience in Chicago at C2E2 to talk all things STAR WARS, Marvel, ATTACK THE BLOCK, and more. UPCOMING EVENTS Alexander Skarsgard in NY 5/12 -- tickets here Tony Gilroy in NY 5/14 -- …
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Bill Maher sits down with Tony Hinchcliffe, the ringmaster behind the hit live podcast Kill Tony. Tony reminisces about his early days answering phones at the Comedy Store, how Mitzi Shore ruled the club, how talent coordinators silently decide careers, the jelly fish ghost in the Belly room, Tony’s Puerto Rico joke at the Trump rally and the socia…
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Lee Coc: Clint Eastwood, Jessica Alba, Gabrielle Union, James Franco, Acting, Music, Prison & more
1:24:31
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1:24:31Episode 28 with Lee Coc, Brian Lally, Verity Van Dams, and Scott Williams. Thank you to our sponsors: LOLAS Acting School https://lolasactingschool.com Patreon https://www.patreon.com/BrianLallyHollywoodNative Chew on Vegan https://www.youtube.com/@ChewonVegan Lee Coc Instagram https://www.instagram.com/leecoc TikTok https://www.tiktok.com/@holdero…
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Jeremy Renner is a survivor, an inspiration, an amazing actor, a superhero, and now an author! Her returns to the podcast to talk about all of it, his long road of recovery after a horrific accident, lessons learned, and what the future holds for him in Marvel and beyond. UPCOMING EVENTS Alexander Skarsgard in NY 5/12 -- tickets here Tony Gilroy …
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On this episode Bill hangs out with author-podcaster Lewis Howes for a free-wheeling chat about life choices and staying sane. They swap stories on moving to L.A., falling in (and out of) love, and how childhood baggage can push you toward self-improvement—or self-destruction. Bill explains why he’s happily child-free and “married to the job,” whil…
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Paul Feig has lived in director's jail and lived to tell the tale. Now he's out though and making crowd-pleaser after crowd-pleaser. Paul joins Josh at a special taping at the Miami Film Festival for a chat about sequels (ANOTHER SIMPLE FAVOR), the legacy of FREAKS & GEEKS, and the success story that is BRIDESMAIDS. UPCOMING EVENTS! Alexander Skars…
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Get a peek behind the STRANGER THINGS curtain with the creative team of STRANGER THINGS: THE FIRST SHADOW! UPCOMING EVENTS! Tony Gilroy in NY 5/14 -- Tickets here! SUPPORT OUR SPONSORS! Quince -- Go to Quince.com/happysadco for 365 day returns and free shipping! Check out the …
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On this episode, Bill hangs out with actor Terrence Howard for a free-wheeling chat that bounces between Hollywood and big ideas. Terrence speaks about clashing with studios over money, why Empire was both a blessing and a headache, and how an early brush with Richard Dreyfus taught him to fight for every scene. He and Bill riff on environmental ju…
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Kaitlyn Dever, Vol. II (THE LAST OF US spoilers!)
59:29
59:29
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59:29SPOILERS for THE LAST OF US season 2, episode 2! Kaitlyn Dever joins Josh to talk about her long history with THE LAST OF US, nearly playing Ellie, getting cast as Abby, her personal loss while filming, and shooting "the scene". #happysadconfused #joshhorowitz #thelastofus #kaitlyndever UPCOMING EVENTS! Tony Gilroy in NY 5/14 -- Tickets here! SUPPO…
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Bitcoin = Home: The Mortgage Revolution No One Saw Coming with Josip Rupena of Milo
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23:44
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23:44Here’s a sentence I never thought I’d say: you can buy a house with your Bitcoin — without ever selling it. That’s the financial revolution Josip Rupena is building. He’s the founder and CEO of Milo, the fintech startup that’s already issued over $60 million in crypto mortgages — loans backed by your Bitcoin, not your bank account. And here’s the k…
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Bryce Dallas Howard returns to talk about her documentary, PETS, her directing career, STAR WARS, plus she gets surprised by her dad, Ron Howard! SUPPORT OUR SPONSORS! Quince -- Go to Quince.com/happysadco for 365 day returns and free shipping! Check out the …
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Crypto, AI Agents, and the Future of Decentralized Infrastructure with Chris “Jinx” Jenkins
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17:32
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17:32My buddy Chris Jenkins just got back from ETHDenver, and he’s buzzing about the convergence of crypto and AI. He’s the head of operations at the Pocket Network Foundation, and right now, they’re gearing up for their biggest protocol upgrade ever: Shannon. What they’re doing is wild — opening up full permissionless access to decentralized data, from…
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On this episode Bill welcomes Turning Point USA founder and conservative firebrand Charlie Kirk. The two sit down for a long‑form, surprisingly cordial debate that roams from identity politics to faith, personal freedom, and the state of American institutions. They spar over marijuana, public safety, the limits of adult choice—topics that segue int…
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Silk Road to Satoshi: Digging Up Bitcoin’s Buried Past with Pete Rizzo
45:03
45:03
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45:03Pete Rizzo Thinks We're Losing Bitcoin's History. I'm Helping Him Fix That. Pete Rizzo’s been called Bitcoin’s historian — and after this conversation, you’ll understand why. He’s spent the past few years diving deep into the stories, people, and drama that built Bitcoin from nothing into a global force. We talk about that work — the threads, the a…
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Emilio Estevez ran away from early fame only to now come full circle with it. He joins Josh to talk about revisiting his early works, from THE BREAKFAST CLUB and THE MIGHTY DUCKS to YOUNG GUNS. SUPPORT OUR SPONSORS! Quince -- Go to Quince.com/happysadco for 365 day returns and free shipping! Check out the …
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Computer Arbitrage, Inefficient Markets, Tariffs, and Monetizing Stranded Energy with Sopris Capital’s Head of Special Situations Dan Wedman
24:33
24:33
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24:33Welcome back, everyone! I sat down with my new friend Daniel Wedman, the head of special situations at Sopris Capital. We delved into a variety of topics, focusing on the dynamic world of Bitcoin and crypto investments, and the evolving landscape of capital markets. Daniel's Career Journey Daniel shared his fascinating career trajectory, starting f…
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THE LAST OF US Season 2 Spoilers w/Craig Mazin
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53:14THE LAST OS US is finally back! And so is co-creator Craig Mazin to spill the secrets about the approach to season 2, casting of chharacters, and the future of the series. SPOILERS ahead if you don't know what happens in the THE LAST OF US 2! You've been warned. UPCOMING EVENTS! April 14th -- Bryce Dallas Howard In New York -- Tickets here! SUPPO…
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On this episode, Bill sits down with musician, podcaster and one-time Mumford & Sons banjoist Winston Marshall. The two reflect on Winston’s departure from the band following a social media firestorm over a controversial book endorsement, how that ordeal exposed the intense pressures of “cancel culture” within the music world and why Winston ultima…
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At barely 21 years of age, Kit Connor is one of the youngest guests in the history of Happy Sad Confused, but to look at his resume he's off to quite the impressive start. He talks about it all from HEARTSTOPPER and his Broadway debut in ROMEO & JULIET to his life-changing experience making WARFARE. UPCOMING EVENTS! April 12th -- C2E2 events in Chi…
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On this episode, Bill catches up with journalist Chris Cuomo. They get into Chris’s current life since his CNN exit, why he’s suing to clear his name, and reflect on the media’s “scalp-hunting” mentality. Chris opens up about growing up in a political dynasty under his father Mario and working closely with his brother Andrew, how policy fights don’…
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Vincent D'Onofrio is an actor's actor. Since making his film debut in FULL METAL JACKET he's always poured his heart and soul into role after role. He joins Josh to talk about his big swings in films like MEN IN BLACK, why he defends the method, and the unexpected gift of playing Kingpin in DAREDEVIL. UPCOMING EVENTS! April 6th -- Paul Feig in Miam…
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If you didn't know his work in New Zealand or in BANSHEE, Antony Starr's powerful performance as Homelander in THE BOYS came as a shock to the system. Who is this guy? Josh gets to the bottom of it, getting to know Antony and his path from comedy to a James Bond audition to the most subversive TV show going. UPCOMING EVENT! Paul Feig -- April 6th i…
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On this episode, Bill sits down with New York Times columnist Maureen Dowd for a wide-ranging, personal chat about her new book “Notorious"—a collection of her incisive profiles of major cultural and political figures—and why she once went viral for a botched edible experience in Denver. The two swap stories about growing up in Washington, D.C. (he…
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In a live taping at Symphony Space in New York, Nathan Lane discusses his return to TV with MID-CENTURY MODERN, his early days in theater, THE BIRDCAGE, THE LION KING, and gets emotional talking about his parents. UPCOMING EVENTS! April 6th -- Paul Feig in Miami -- Tickets here! April 12th -- C2E2 events in Chicago -- Tickets here! April 14th -…
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