Peptidiltransferaza
(Preusmjereno sa stranice Peptidil transferaza)
| Peptidiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.3.2.12 | ||||||||
| CAS broj | 9059-29-4 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Peptidiltransferaza (EC 2.3.2.12, transpeptidaza, ribosomalna peptidiltransferaza) je enzim sa sistematskim imenom peptidil-tRNK:aminoacil-tRNK N-peptidiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- peptidil-tRNK1 + aminoacil-tRNK2 tRNK1 + peptidil(aminoacil-tRNK2)
Ovaj enzim je ribozim. Dve neekvivantne ribonukleoproteinske podjednice deluju na neusaglažen način pri peptidnoj elongaciji.
- ↑ Rychlik, I. (1966). „Release of lysine peptides by puromycin from polylysyl-transfer ribonucleic acid in the presence of ribosomes”. Biochim. Biophys. Acta 114: 425-427. PMID 5329275.
- ↑ Rychlik, I., Cerná, J., Chládek, S., Zemlicka, J. and Haladová, Z. (1969). „Substrate specificity of ribosomal peptidyl transferase: 2′(3′)-O-aminoacyl nucleosides as acceptors of the peptide chain on the amino acid site”. J. Mol. Biol. 43: 13-24. PMID 4897787.
- ↑ Traut, R.R. and Monro, R.E. (1964). „The puromycin reaction and its relation to protein synthesis”. J. Mol. Biol. 10: 63-72.
- ↑ Voorhees, R.M., Weixlbaumer, A., Loakes, D., Kelley, A.C. and Ramakrishnan, V. (2009). „Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome”. Nat. Struct. Mol. Biol. 16: 528-533. PMID 19363482.
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