<p>The relationships among Vt by Logan plot analysis, SUV at 30 min, radioactivity count by... more <p>The relationships among Vt by Logan plot analysis, SUV at 30 min, radioactivity count by well counter, and AChE activity by fluorometric assay.</p
ABSTRACT Positron emission tomography (PET) with [F-18]-FDG can display cancerous activity depend... more ABSTRACT Positron emission tomography (PET) with [F-18]-FDG can display cancerous activity depending on glucose uptake. Consequently, different PET tracers with different metabolisms are needed for further indication. We have developed multifunctional PET agents by combining Zn-62(2+) ion with laserphyrin (R) and bisglycosylated 5,10,15,20-tetrakis (pentafluorophenyl)porphyrins (H(2)Glccis-2 and H(2)Glctrans-2), which can be easily synthesized and have a half-life of 9 h. Zn-62-Labeled chemicals were successfully detected as PET signals in vivo and showed PDT-induced cell death by photoirradiation.
In nuclear medicine, the development of portable imaging devices that provide high imaging resolu... more In nuclear medicine, the development of portable imaging devices that provide high imaging resolution and sensitivity, capable of imaging gamma rays with a wide energy range and multiple radioisotopes tracing capabilities, is so important. These goals have been possible thanks to developing a compact Compton camera, a collimatorless detector coupled to compact silicon photomultiplier(SiPM) array, using scintillator crystal. In this study, the portable segmented GAGG:Ce scintillator-based Compton camera (CC) is optimized with the GATE, a Monte Carlo simulation toolkit based on Geant4, to maximize its performance for a wide range of gamma-ray energy (364–1000 keV). The geometrical parameters are selected as optimization parameters to investigate their effects on CC's performance, including imaging resolution and absolute detection efficiency (DE a ). The geometry parameters of CC include the planner area of scatterer and absorber detectors, their thicknesses, and the distance between them. The results for the energy range of 364–1000 keV show that the most important contributions to the spatial resolution and DE a of the camera are SAD (scatterer to absorber distance) and the scatterer area while changing absorber area (AA ) showed the most negligible impact. In the short SADs, imaging resolution and DE a are significantly affected by the detector's size and thickness. On the other hand, in the long SADs (&gt; 4 cm), both spatial resolution and DE a are significantly affected by the detector's area but less affected by the detector's thickness. Decreasing the scatterer's thickness and the absorber's size or thickness improves imaging resolution without significantly reducing DE a . The simulation study's findings presented here will provide valuable guidelines for researchers choosing a desired CC's design according to particular objectives, manufacturing limitations in scintillator growth, cost, etc.
With the aim of providing critical nuclear data of primary knock-on atoms (PKAs) created from pro... more With the aim of providing critical nuclear data of primary knock-on atoms (PKAs) created from proton-induced spallation reactions, a new detection system was designed and dedicated to the PKA measurement that requires lower measurement threshold energies and superior mass resolution than the conventional experimental setups. Such requirements can be fulfilled by employing the TOF-E and dE-E methods, and this new PKA detection system, which consists of two fast timing detectors and one dE-E gas ionization detector. The design of the detectors and the experimental setup, along with the estimated system performed are briefly described in this paper.
In our previous work, a cost-effective Compton camera (CC) using Ce doped Gd3(Al,Ga)5O12(Ce:GAGG)... more In our previous work, a cost-effective Compton camera (CC) using Ce doped Gd3(Al,Ga)5O12(Ce:GAGG) scintillator consisting of two detectors, scatterer (20.8 × 20.8 × 5 mm3) and absorber (41.7 × 41.7 × 10 mm3), was developed to image gamma rays having energy more than 511 keV. This study fabricated a newly developed CC with a larger scatterer and thinner absorber. The system consists of two detectors: a scatterer and an absorber of Ce:GAGG scintillator. The size of the scatterer and absorber is the same; a 40-mm × 40-mm × 5-mm array block consists of 40 × 40 pixels. The size of each scintillator pixel is 0.85 mm × 0.85 mm for both systems. Imaging experiments of Na-22 and Cs-137 point sources were performed to investigate the imaging capability of the new camera, and then the obtained data were compared to the previous CC. The current CC's absolute detection efficiency (DE a ) and photopeak detection efficiency (DE p ) are improved by 1.6 and 2 times greater than the previous one. At the same time, both systems' spatial and angular resolutions are almost the same value at 511 keV. The Compton camera module (CCMod) in GATE v9.0 was employed for Monte Carlo simulations to reproduce the experimental data showing a good agreement.
The present work introduced a framework to investigate the effectiveness of proton boron fusion t... more The present work introduced a framework to investigate the effectiveness of proton boron fusion therapy (PBFT) at the cellular level. The framework consisted of a cell array generator program coupled with PHITS Monte Carlo package with a dedicated terminal-based code editor that was developed in this work. The framework enabled users to model large cell arrays with normal, all boron, and random boron filled cytoplasm, to investigate the underlying mechanism of PBFT. It was found that alpha particles and neutrons could be produced in absence of boron mainly because of nuclear reaction induced by proton interaction with 16O, 12C and 14N nuclei. The effectiveness of PBFT is highly dependent on the incident proton energy, source size, cell array size, buffer medium thickness layer, concentration and distribution of boron in the cell array. To quantitatively assess the effectiveness of PBFT, of the total energy deposition by alpha particle for different cases were determined. The number ...
To evaluate tumor blood flow using 15O-water positron emission tomography (PET) in patients with ... more To evaluate tumor blood flow using 15O-water positron emission tomography (PET) in patients with non-small cell lung cancer (NSCLC) before and after chemotherapy with bevacizumab, and to investigate the effects of bevacizumab on tumor blood flow changes and progression-free survival (PFS). Twelve patients with NSCLC were enrolled. Six patients underwent chemotherapy with bevacizumab and the other six without bevacizumab. 15O-water dynamic PET scans were performed within 1 week before the start of chemotherapy and within 1 week after the first day of chemotherapy. Tumor blood flow was analyzed quantitatively using a single one-tissue compartment model with the correction of pulmonary circulation blood volume and arterial blood volume via an image-derived input function. In the bevacizumab group, mean tumor blood flow was statistically significantly reduced post-chemotherapy (pre-chemotherapy 0.27 ± 0.14 mL/cm3/min, post-chemotherapy 0.18 ± 0.12 mL/cm3/min). In the no bevacizumab grou...
American journal of nuclear medicine and molecular imaging, 2019
Image statistics are frequently used for functional and molecular imaging research in which image... more Image statistics are frequently used for functional and molecular imaging research in which images from a patient group with a specific diagnosis are compared with images from a healthy control group who have been matched for demographic variables. The success of image statistics for brain imaging has encouraged us to develop a method for obtaining volumetrically normalized kidney to perform image statistics so that we can locally visualize the statistical significant difference comparing voxel by voxel between certain groups in terms kidney blood flow kinetic parameters. For the development of this evolutionary process, we first volumetrically normalized all subjects, which include healthy control (HC) and chronic renal failure (CRF) patients, 15O water PET image with respect to one HC subject's MRI image using affine transformation. Then 15O kinetic parametric images of normalized kidneys were obtained through the basis function method. Finally, the statistical map of these pa...
Simulations and numerical analysis of physical problems are important steps toward understanding ... more Simulations and numerical analysis of physical problems are important steps toward understanding underlying mechanisms of the processes. Important examples would be medical physics and medical imaging. Compartmental modeling has been found useful for estimating the transport and temporal variations of drugs/contaminants (commonly used in medical physics and medical imaging) in different organs, given that different organs would be modeled as compartments. Recycling among these modeled compartments (i.e., organs) was allowed through defining sets of constant transfer rates. In order to mathematically define these systems, one needs to use sets of differential equations (depending on the number of compartments) which would in fact be time-consuming and prone to mathematical error. Considering these issues, there is a need for a versatile computer program that is accurate, robust, and user-friendly to perform the required computations automatically. In the present work, we developed an...
Functional near-infrared spectroscopy (fNIRS) is an optical imaging tool to study brain activitie... more Functional near-infrared spectroscopy (fNIRS) is an optical imaging tool to study brain activities. Moreover, many researchers combined fNIRS with other modalities to gain a better understanding of the brain. This paper provides an overview of the combination of fNIRS with other imaging modalities in the detection and measurement of the cerebral hemodynamic. Cerebral haemodynamic such as the cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral blood oxygenation (CBO) are the important parameters in many neuroimaging studies. Cerebral hemodynamic had been studied by various medical imaging modalities. Initially, Xenon enhanced Computed Tomography (Xenon CT), Computed Tomography (CT) perfusion; Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET) are used to measure the cerebral hemodynamic. Recently, fNIRS is used to optically observe the changes in cerebral haemodynamic during brain activities and the combination of fNIRS with other ...
We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using ... more We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using fluorodeoxyglucose (F-FDG) can reveal extension of breast cancer in breast-conserving surgery (BCS), and assess the safety of radiation exposure to medical staff. Sixteen patients underwent positron emission tomography, and then BCS with intraoperative frozen section analysis on the same day. Resected specimens with remainingF-FDG accumulation were scanned by high-resolution PEM. At least 1 day after surgery, tumour extension was evaluated by three independent experienced readers and by binarized images from the specimen-PEM data. Intraoperative exposure of medical staff toF-FDG was measured. Specimen-PEM evaluations of binarized images and the three investigators detected all (100 %, 12/12) invasive lesions and 94.4 % (17/18) of in situ lesions using both methods. The positive predictive value of the accumulated lesions was 74.4 % (29/39) for the binarized images and 82.9 % (29/35) for ...
<p>The relationships among Vt by Logan plot analysis, SUV at 30 min, radioactivity count by... more <p>The relationships among Vt by Logan plot analysis, SUV at 30 min, radioactivity count by well counter, and AChE activity by fluorometric assay.</p
ABSTRACT Positron emission tomography (PET) with [F-18]-FDG can display cancerous activity depend... more ABSTRACT Positron emission tomography (PET) with [F-18]-FDG can display cancerous activity depending on glucose uptake. Consequently, different PET tracers with different metabolisms are needed for further indication. We have developed multifunctional PET agents by combining Zn-62(2+) ion with laserphyrin (R) and bisglycosylated 5,10,15,20-tetrakis (pentafluorophenyl)porphyrins (H(2)Glccis-2 and H(2)Glctrans-2), which can be easily synthesized and have a half-life of 9 h. Zn-62-Labeled chemicals were successfully detected as PET signals in vivo and showed PDT-induced cell death by photoirradiation.
In nuclear medicine, the development of portable imaging devices that provide high imaging resolu... more In nuclear medicine, the development of portable imaging devices that provide high imaging resolution and sensitivity, capable of imaging gamma rays with a wide energy range and multiple radioisotopes tracing capabilities, is so important. These goals have been possible thanks to developing a compact Compton camera, a collimatorless detector coupled to compact silicon photomultiplier(SiPM) array, using scintillator crystal. In this study, the portable segmented GAGG:Ce scintillator-based Compton camera (CC) is optimized with the GATE, a Monte Carlo simulation toolkit based on Geant4, to maximize its performance for a wide range of gamma-ray energy (364–1000 keV). The geometrical parameters are selected as optimization parameters to investigate their effects on CC's performance, including imaging resolution and absolute detection efficiency (DE a ). The geometry parameters of CC include the planner area of scatterer and absorber detectors, their thicknesses, and the distance between them. The results for the energy range of 364–1000 keV show that the most important contributions to the spatial resolution and DE a of the camera are SAD (scatterer to absorber distance) and the scatterer area while changing absorber area (AA ) showed the most negligible impact. In the short SADs, imaging resolution and DE a are significantly affected by the detector's size and thickness. On the other hand, in the long SADs (&gt; 4 cm), both spatial resolution and DE a are significantly affected by the detector's area but less affected by the detector's thickness. Decreasing the scatterer's thickness and the absorber's size or thickness improves imaging resolution without significantly reducing DE a . The simulation study's findings presented here will provide valuable guidelines for researchers choosing a desired CC's design according to particular objectives, manufacturing limitations in scintillator growth, cost, etc.
With the aim of providing critical nuclear data of primary knock-on atoms (PKAs) created from pro... more With the aim of providing critical nuclear data of primary knock-on atoms (PKAs) created from proton-induced spallation reactions, a new detection system was designed and dedicated to the PKA measurement that requires lower measurement threshold energies and superior mass resolution than the conventional experimental setups. Such requirements can be fulfilled by employing the TOF-E and dE-E methods, and this new PKA detection system, which consists of two fast timing detectors and one dE-E gas ionization detector. The design of the detectors and the experimental setup, along with the estimated system performed are briefly described in this paper.
In our previous work, a cost-effective Compton camera (CC) using Ce doped Gd3(Al,Ga)5O12(Ce:GAGG)... more In our previous work, a cost-effective Compton camera (CC) using Ce doped Gd3(Al,Ga)5O12(Ce:GAGG) scintillator consisting of two detectors, scatterer (20.8 × 20.8 × 5 mm3) and absorber (41.7 × 41.7 × 10 mm3), was developed to image gamma rays having energy more than 511 keV. This study fabricated a newly developed CC with a larger scatterer and thinner absorber. The system consists of two detectors: a scatterer and an absorber of Ce:GAGG scintillator. The size of the scatterer and absorber is the same; a 40-mm × 40-mm × 5-mm array block consists of 40 × 40 pixels. The size of each scintillator pixel is 0.85 mm × 0.85 mm for both systems. Imaging experiments of Na-22 and Cs-137 point sources were performed to investigate the imaging capability of the new camera, and then the obtained data were compared to the previous CC. The current CC's absolute detection efficiency (DE a ) and photopeak detection efficiency (DE p ) are improved by 1.6 and 2 times greater than the previous one. At the same time, both systems' spatial and angular resolutions are almost the same value at 511 keV. The Compton camera module (CCMod) in GATE v9.0 was employed for Monte Carlo simulations to reproduce the experimental data showing a good agreement.
The present work introduced a framework to investigate the effectiveness of proton boron fusion t... more The present work introduced a framework to investigate the effectiveness of proton boron fusion therapy (PBFT) at the cellular level. The framework consisted of a cell array generator program coupled with PHITS Monte Carlo package with a dedicated terminal-based code editor that was developed in this work. The framework enabled users to model large cell arrays with normal, all boron, and random boron filled cytoplasm, to investigate the underlying mechanism of PBFT. It was found that alpha particles and neutrons could be produced in absence of boron mainly because of nuclear reaction induced by proton interaction with 16O, 12C and 14N nuclei. The effectiveness of PBFT is highly dependent on the incident proton energy, source size, cell array size, buffer medium thickness layer, concentration and distribution of boron in the cell array. To quantitatively assess the effectiveness of PBFT, of the total energy deposition by alpha particle for different cases were determined. The number ...
To evaluate tumor blood flow using 15O-water positron emission tomography (PET) in patients with ... more To evaluate tumor blood flow using 15O-water positron emission tomography (PET) in patients with non-small cell lung cancer (NSCLC) before and after chemotherapy with bevacizumab, and to investigate the effects of bevacizumab on tumor blood flow changes and progression-free survival (PFS). Twelve patients with NSCLC were enrolled. Six patients underwent chemotherapy with bevacizumab and the other six without bevacizumab. 15O-water dynamic PET scans were performed within 1 week before the start of chemotherapy and within 1 week after the first day of chemotherapy. Tumor blood flow was analyzed quantitatively using a single one-tissue compartment model with the correction of pulmonary circulation blood volume and arterial blood volume via an image-derived input function. In the bevacizumab group, mean tumor blood flow was statistically significantly reduced post-chemotherapy (pre-chemotherapy 0.27 ± 0.14 mL/cm3/min, post-chemotherapy 0.18 ± 0.12 mL/cm3/min). In the no bevacizumab grou...
American journal of nuclear medicine and molecular imaging, 2019
Image statistics are frequently used for functional and molecular imaging research in which image... more Image statistics are frequently used for functional and molecular imaging research in which images from a patient group with a specific diagnosis are compared with images from a healthy control group who have been matched for demographic variables. The success of image statistics for brain imaging has encouraged us to develop a method for obtaining volumetrically normalized kidney to perform image statistics so that we can locally visualize the statistical significant difference comparing voxel by voxel between certain groups in terms kidney blood flow kinetic parameters. For the development of this evolutionary process, we first volumetrically normalized all subjects, which include healthy control (HC) and chronic renal failure (CRF) patients, 15O water PET image with respect to one HC subject's MRI image using affine transformation. Then 15O kinetic parametric images of normalized kidneys were obtained through the basis function method. Finally, the statistical map of these pa...
Simulations and numerical analysis of physical problems are important steps toward understanding ... more Simulations and numerical analysis of physical problems are important steps toward understanding underlying mechanisms of the processes. Important examples would be medical physics and medical imaging. Compartmental modeling has been found useful for estimating the transport and temporal variations of drugs/contaminants (commonly used in medical physics and medical imaging) in different organs, given that different organs would be modeled as compartments. Recycling among these modeled compartments (i.e., organs) was allowed through defining sets of constant transfer rates. In order to mathematically define these systems, one needs to use sets of differential equations (depending on the number of compartments) which would in fact be time-consuming and prone to mathematical error. Considering these issues, there is a need for a versatile computer program that is accurate, robust, and user-friendly to perform the required computations automatically. In the present work, we developed an...
Functional near-infrared spectroscopy (fNIRS) is an optical imaging tool to study brain activitie... more Functional near-infrared spectroscopy (fNIRS) is an optical imaging tool to study brain activities. Moreover, many researchers combined fNIRS with other modalities to gain a better understanding of the brain. This paper provides an overview of the combination of fNIRS with other imaging modalities in the detection and measurement of the cerebral hemodynamic. Cerebral haemodynamic such as the cerebral blood flow (CBF), cerebral blood volume (CBV) and cerebral blood oxygenation (CBO) are the important parameters in many neuroimaging studies. Cerebral hemodynamic had been studied by various medical imaging modalities. Initially, Xenon enhanced Computed Tomography (Xenon CT), Computed Tomography (CT) perfusion; Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET) are used to measure the cerebral hemodynamic. Recently, fNIRS is used to optically observe the changes in cerebral haemodynamic during brain activities and the combination of fNIRS with other ...
We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using ... more We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using fluorodeoxyglucose (F-FDG) can reveal extension of breast cancer in breast-conserving surgery (BCS), and assess the safety of radiation exposure to medical staff. Sixteen patients underwent positron emission tomography, and then BCS with intraoperative frozen section analysis on the same day. Resected specimens with remainingF-FDG accumulation were scanned by high-resolution PEM. At least 1 day after surgery, tumour extension was evaluated by three independent experienced readers and by binarized images from the specimen-PEM data. Intraoperative exposure of medical staff toF-FDG was measured. Specimen-PEM evaluations of binarized images and the three investigators detected all (100 %, 12/12) invasive lesions and 94.4 % (17/18) of in situ lesions using both methods. The positive predictive value of the accumulated lesions was 74.4 % (29/39) for the binarized images and 82.9 % (29/35) for ...
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Papers by Hiroshi Watabe