Papers by Kjell Erlandsson
The British Journal of Radiology, 2016
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2008
In European Journal of Nuclear Medicine and Molecular Imaging, 2002
Information Processing in Medical Imaging, 1997
In Khalil Mm Basic Sciences of Nuclear Medicine Springer Verlag Berlin Germany, 2011
In European Journal of Nuclear Medicine and Molecular Imaging, Oct 1, 2012
Journal of Cerebral Blood Flow & Metabolism, 2016
Kinetic analysis of (18)F-fluorodeoxyglucose positron emission tomography data requires an accura... more Kinetic analysis of (18)F-fluorodeoxyglucose positron emission tomography data requires an accurate knowledge the arterial input function. The gold standard method to measure the arterial input function requires collection of arterial blood samples and is an invasive method. Measuring an image derived input function is a non-invasive alternative but is challenging due to partial volume effects caused by the limited spatial resolution of the positron emission tomography scanners. In this work, a practical image derived input function extraction method is presented, which only requires segmentation of the carotid arteries from MR images. The simulation study results showed that at least 92% of the true intensity could be recovered after the partial volume correction. Results from 19 subjects showed that the mean cerebral metabolic rate of glucose calculated using arterial samples and partial volume corrected image derived input function were 26.9 and 25.4 mg/min/100 g, respectively, for the grey matter and 7.2 and 6.7 mg/min/100 g for the white matter. No significant difference in the estimated cerebral metabolic rate of glucose values was observed between arterial samples and corrected image derived input function (p > 0.12 for grey matter and white matter). Hence, the presented image derived input function extraction method can be a practical alternative to noninvasively analyze dynamic (18)F-fluorodeoxyglucose data without the need for blood sampling.
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2008
Cancer Biotherapy and Radiopharmaceuticals, Nov 1, 2004
Studies on animals with gliomas inoculated in the brain and treated with intratumoral injections ... more Studies on animals with gliomas inoculated in the brain and treated with intratumoral injections of 201Tl-chloride have previously shown very promising results, with a survival several weeks longer than controls. Total regression was found in some animals, and necrosis was found in all the 201Tl-treated brain tumors. This study was undertaken to estimate the absorbed dose and dose distribution to the tumor based on the localization and clearance properties obtained from images with two high-resolution imaging techniques; pinhole single photon emission computed tomography (SPECT) and beta-camera. The images from the beta-camera were used to calculate the absorbed dose rate, using an in-house-developed, voxel-based Monte Carlo program, based on the EGS4 package. To evaluate the effects of different beta-particle energies on the absorbed dose rate distribution, simulations of medium- and high-energy electrons were conducted. Dose-volume histograms from these simulations show that the energy absorption is very locally distributed for 201Tl and medium energy, whereas high-energy beta emitters show a broader dose-volume distribution. The calculated total absorbed dose of 2-8 Gy in the tumor seems to be relativity low when considering the therapeutic effect that was seen. Further investigations, to determine the cause of the high therapeutic efficacy, are needed.
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2011
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2008
Journal of Nuclear Medicine Technology, Feb 1, 1994
and other new radiopharmaceuticais for imaging and ther apy (1â€"3) place new demands on the need... more and other new radiopharmaceuticais for imaging and ther apy (1â€"3) place new demands on the need for high spatial resolution techniques to investigate the regional localiza tion propertiesof these radiopharmaceuticalsin preclinical and clinical studies.
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2009
Ieee Nuclear Science Symposium Conference Record Nuclear Science Symposium, 2010
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2009
Obstetrics Gynaecology Reproductive Medicine, 2003
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2010
Society of Nuclear Medicine Annual Meeting Abstracts, May 1, 2010
2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC), 2014
ABSTRACT
Proceedings of Spie the International Society For Optical Engineering 4322 804 813, Jul 1, 2001
Patient motion in gamma camera coincidence imaging results in severe reconstruction artifacts. A ... more Patient motion in gamma camera coincidence imaging results in severe reconstruction artifacts. A protocol is proposed to automatically detect and correct motion from SPECT coincidence studies. The method is based on fractionating the acquisition into three full ...
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Papers by Kjell Erlandsson