Introduzione: La diagnosi dei disturbi di personalità (DP), soprattutto se categoriale ed effettu... more Introduzione: La diagnosi dei disturbi di personalità (DP), soprattutto se categoriale ed effettuata attraverso strumenti differenti è spesso poco attendibile. Il DSM 5 ha proposto pertanto un nuovo modello gerarchico e multidimensionale. La relazione tra DP e disturbi dell'umore è complessa e molte questioni metodologiche restano aperte: scarsità e contraddittorietà dei dati, mancanza di teorie eziologiche definite, farmacoresistenza dei pazienti comorbidi che presentano decorso e outcome peggiori, anche nelle forme sotto-soglia. Metodi: 30 pazienti con disturbi dell'umore sono stati sottoposti a screening con il questionario self-report della SCID-5-PD e successivamente diagnosticati con la SCID-5-PD, il Dimensional Assessment of Personality Pathology - Basic Questionnaire (DAPP-BQ) e l'Inventario di Personalità per il DSM 5 (PID-5). Risultati: Le diagnosi dimensionali e la variabile “caratteristiche clinicamente significative” consentono di predire tratti psicopatolog...
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus... more Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a particular risk to people living with preexisting conditions that impair immune response or amplify pro-inflammatory response. Low-grade chronic systemic inflammation, common in people with obesity, is associated with the development of atherosclerosis, type 2 diabetes, and hypertension, well known comorbidities that adversely affect the outcomes of patients with COVID-19. Risk stratification based on the Edmonton Obesity Staging System (EOSS), which classifies obesity based on the presence of medical, mental, and/or functional complications rather than on body mass index (BMI), has been shown to be a better predictor of all-cause mortality and it may well be that EOSS stages may better describe the risk of hyperinflammation in patients with COVID-19 infection. Analyzing a group of metabolic ill patients with obesity (EOSS 2 and 3), we found an increased interleukin-6 and linear regression analysis showed a positive correlation with C-reactive protein (CRP) (p = 0.014) and waist-to-hip-ratio (WHR) (p = 0.031). Physicians should be aware of these findings in patients with COVID-19 infection. Early identification of possible hyperinflammation could be fundamental and should guide decision making regarding hospitalization, early respiratory support, and therapy with immunosuppression to improve mortality.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Background: The late positive potential (LPP) could be a marker of emotion dysregulation in youth... more Background: The late positive potential (LPP) could be a marker of emotion dysregulation in youth with pediatric bipolar disorder (PBD). However, the neuroanatomical correlates of the LPP are still not clarified. Objective: To provide cortical and deep gray matter correlates of the LPP in youth, specifically youth with PBD. Methods: Twenty-four 7 to 17 years-old children with PBD and 28 healthy controls (HC) underwent cortical thickness and deep gray matter volumes measurements through magnetic resonance imaging and LPP measurement elicited by passively viewing of emotional faces through electroencephalography. T-tests compared group differences in LPP, cortical thickness, and deep gray matter volumes. Linear regressions tested the relationship between LPP amplitude and cortical thickness/deep gray matter volumes. Results: PBD had a more pronounced LPP amplitude for happy faces and a thinner cortex in prefrontal areas than HC. While considering both groups, a higher LPP amplitude wa...
International Journal of Environmental Research and Public Health
In line with priorities set by the Italian Ministry of Health and international literature, the “... more In line with priorities set by the Italian Ministry of Health and international literature, the “Crisalide project” provides specific care pathways aimed at young adults (YA) with severe mental disorders (SMD). As described in Materials and Methods, it consists of three lines of activity: transition to adult mental health services (TSMREE/CSM 17–19); Diagnostic, Therapeutic, and Assistance Pathways for Young Adults (PDTA-YA); high-intensity treatment center for young adults “Argolab2 Potential Space”. The aim of the study is to assess the results relating to the first three years of implementation of this clinical-organizational model (2018/2020) according to the process indicators identified by the ministry. Among the population aged 18–30 under treatment, results show increased prevalence (30%) and incidence (26%); 0% treatment conclusions due to the expiration of the conventional time limit; 0% involuntary hospitalizations (TSO); 0% STPIT hospitalizations; 0% repeated hospitaliza...
Introduzione: La diagnosi dei disturbi di personalità (DP), soprattutto se categoriale ed effettu... more Introduzione: La diagnosi dei disturbi di personalità (DP), soprattutto se categoriale ed effettuata attraverso strumenti differenti è spesso poco attendibile. Il DSM 5 ha proposto pertanto un nuovo modello gerarchico e multidimensionale. La relazione tra DP e disturbi dell'umore è complessa e molte questioni metodologiche restano aperte: scarsità e contraddittorietà dei dati, mancanza di teorie eziologiche definite, farmacoresistenza dei pazienti comorbidi che presentano decorso e outcome peggiori, anche nelle forme sotto-soglia. Metodi: 30 pazienti con disturbi dell'umore sono stati sottoposti a screening con il questionario self-report della SCID-5-PD e successivamente diagnosticati con la SCID-5-PD, il Dimensional Assessment of Personality Pathology - Basic Questionnaire (DAPP-BQ) e l'Inventario di Personalità per il DSM 5 (PID-5). Risultati: Le diagnosi dimensionali e la variabile “caratteristiche clinicamente significative” consentono di predire tratti psicopatolog...
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus... more Coronavirus disease 2019 (COVID-19) and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a particular risk to people living with preexisting conditions that impair immune response or amplify pro-inflammatory response. Low-grade chronic systemic inflammation, common in people with obesity, is associated with the development of atherosclerosis, type 2 diabetes, and hypertension, well known comorbidities that adversely affect the outcomes of patients with COVID-19. Risk stratification based on the Edmonton Obesity Staging System (EOSS), which classifies obesity based on the presence of medical, mental, and/or functional complications rather than on body mass index (BMI), has been shown to be a better predictor of all-cause mortality and it may well be that EOSS stages may better describe the risk of hyperinflammation in patients with COVID-19 infection. Analyzing a group of metabolic ill patients with obesity (EOSS 2 and 3), we found an increased interleukin-6 and linear regression analysis showed a positive correlation with C-reactive protein (CRP) (p = 0.014) and waist-to-hip-ratio (WHR) (p = 0.031). Physicians should be aware of these findings in patients with COVID-19 infection. Early identification of possible hyperinflammation could be fundamental and should guide decision making regarding hospitalization, early respiratory support, and therapy with immunosuppression to improve mortality.
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Background: The late positive potential (LPP) could be a marker of emotion dysregulation in youth... more Background: The late positive potential (LPP) could be a marker of emotion dysregulation in youth with pediatric bipolar disorder (PBD). However, the neuroanatomical correlates of the LPP are still not clarified. Objective: To provide cortical and deep gray matter correlates of the LPP in youth, specifically youth with PBD. Methods: Twenty-four 7 to 17 years-old children with PBD and 28 healthy controls (HC) underwent cortical thickness and deep gray matter volumes measurements through magnetic resonance imaging and LPP measurement elicited by passively viewing of emotional faces through electroencephalography. T-tests compared group differences in LPP, cortical thickness, and deep gray matter volumes. Linear regressions tested the relationship between LPP amplitude and cortical thickness/deep gray matter volumes. Results: PBD had a more pronounced LPP amplitude for happy faces and a thinner cortex in prefrontal areas than HC. While considering both groups, a higher LPP amplitude wa...
International Journal of Environmental Research and Public Health
In line with priorities set by the Italian Ministry of Health and international literature, the “... more In line with priorities set by the Italian Ministry of Health and international literature, the “Crisalide project” provides specific care pathways aimed at young adults (YA) with severe mental disorders (SMD). As described in Materials and Methods, it consists of three lines of activity: transition to adult mental health services (TSMREE/CSM 17–19); Diagnostic, Therapeutic, and Assistance Pathways for Young Adults (PDTA-YA); high-intensity treatment center for young adults “Argolab2 Potential Space”. The aim of the study is to assess the results relating to the first three years of implementation of this clinical-organizational model (2018/2020) according to the process indicators identified by the ministry. Among the population aged 18–30 under treatment, results show increased prevalence (30%) and incidence (26%); 0% treatment conclusions due to the expiration of the conventional time limit; 0% involuntary hospitalizations (TSO); 0% STPIT hospitalizations; 0% repeated hospitaliza...
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