Gregory Auner

Wayne State University, Surgery, Faculty Member

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Undergraduate degrees in Physics and Biology, Masters in Physics, and Ph.D. in Physics. Dr. Auner currently holds the Strauss TEAMS Endowed Chair and is a Professor in the Department of Surgery and Biomedical Engineering at Wayne State University. He also has appointments in the Department of Physics and Astronomy, Karmanos Cancer Institute, and the Department of of Ophthalmology at Henry Ford Health Systems He is the founder and Director of the Smart Sensors and Integrated Microsystems Program. He has performed a litany of advanced biomedical research and development for the DOD, NIH, NASA, DOE, DTRA, and a host of industries. These projects include real time pathogen detection in fluid and air, neurological implants (under clinical evaluation), self powered (scavenger) bioimplants, and miniature genetic analysis systems to name a few. Dr. Auner has been appointed to the National Academies Board on Manufacturing and Engineering Design and has over 250 publications. His SSIM program has pioneered the development of advanced microsystems from the scientific ‘bench’ into the medical arena. He has formed a consortium within the Smart Sensors Program involving Karmanos Cancer Institute (Ultrasonic Breast Cancer Detection System), Henry Ford Health Systems ( research in real time detection of tumors in the brain and lung as well as the development of a heart assist implantable pump) and the Detroit Medical Center/Children’s Hospital of Michigan (Robotic Surgery and Real Time Surgical Diagnostics). His program is the main microsystems technology for these initiatives. Dr. Auner has over 30 patents (issued and pending) in the last few years for chemical, biomedical, and environmental sensors and microsystems and has been granted more than $35 million in research grants and contracts as principle investigator. He was recently appointed the Director of Research for the Detroit Institute of Ophthalmology in the Department of Ophthalmology at Henry Ford Health Systems. He is the Chief Technology Officer and Co-Founder of Visca, LLC, and Chief Science and Technology Officer for Medical Engineering Partners (MEP) in Detroit, MI.

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Adrian Iftene

Universitatea Alexandru Ioan Cuza Iasi

Francesco Bardozzo

University of Salerno

Igor Tsigelny

Ana Zulijani

University of Rijeka, Faculty of Medicine

RIKEN

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Papers by Gregory Auner

Artificial intelligence-cogito, ergo sum

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Check valve diaphragm micropump

Robotics technology: a journey into the future

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Joystick mapped Augmented Reality cues for end-effector controlled tele-operated Robots

… , 2007. VR'07. IEEE, Mar 10, 2007

End-effector control of robots using just remote camera views is difficult due to lack of perceiv... more End-effector control of robots using just remote camera views is difficult due to lack of perceived correspondence between the joysticks and the end-effector coordinate frame. This paper reports the positive effects of augmented reality visual cues on operator performance during end-effector controlled tele-operation using only camera views. Our solution is to overlay a color-coded coordinate system on the end-effector of the robot using AR techniques. This mapped and color-coded coordinate system is then directly mapped ...

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Raman spectral signatures of mouse mammary tissue and associated lymph nodes: normal, tumor and mastitis

Journal of Raman …, 2007

1 Department of Electrical and Computer Engineering, Wayne State University, Detroit, MI 48202, U... more

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Applications of Raman spectroscopy in cancer diagnosis

Cancer and Metastasis Reviews

Novel approaches toward understanding the evolution of disease can lead to the discovery of bioma... more Novel approaches toward understanding the evolution of disease can lead to the discovery of biomarkers that will enable better management of disease progression and improve prognostic evaluation. Raman spectroscopy is a promising investigative and diagnostic tool that can assist in uncovering the molecular basis of disease and provide objective, quantifiable molecular information for diagnosis and treatment evaluation. This technique probes molecular vibrations/rotations associated with chemical bonds in a sample to obtain information on molecular structure, composition, and intermolecular interactions. Raman scattering occurs when light interacts with a molecular vibration/rotation and a change in polarizability takes place during molecular motion. This results in light being scattered at an optical frequency shifted (up or down) from the incident light. By monitoring the intensity profile of the inelastically scattered light as a function of frequency, the unique spectroscopic fingerprint of a tissue sample is obtained. Since each sample has a unique composition, the spectroscopic profile arising from Raman-active functional groups of nucleic acids, proteins, lipids, and carbohydrates allows for the evaluation, characterization, and discrimination of tissue type. This review provides an overview of the theory of Raman spectroscopy, instrumentation used for measurement, and variation of Raman spectroscopic techniques for clinical applications in cancer, including detection of brain, ovarian, breast, prostate, and pancreatic cancers and circulating tumor cells.

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Intraoperative Raman Spectroscopy

Neurosurgery clinics of North America, 2017

Surface Modification and Neural Tissue Culture of Thin Film Electrode Materials

MRS Proceedings, 2005

Good interfaces between electrodes and neural tissue are very important in chronic in vivo stimul... more Good interfaces between electrodes and neural tissue are very important in chronic in vivo stimulation/recording. In order to study the effect of electrode materials and surface structure on neural interfaces, we cultured neurons on thin films of electrode materials that are expected to be biocompatible, such as platinum, and iridium oxide.We used both flat film surfaces and laser micro-structured ones. The laser micro-structuring consisted of creating regular arrays of micro-bumps with height of about 1μm and diameter of 2-3 microns. We have found conditions for fabrication of such micro-bumps on platinum and iridium thin films on borosilicate glass substrate (Pyrex 7740) by mask-projection irradiation with single nano-second pulses from a KrF excimer laser (λ=248nm). Laser micro-structured iridium films were coated with IrO2 by pulsed DC reactive sputtering to obtain micro-structured IrO2 films. Two types of iridium oxide films were studied: amorphous (reactively sputtered at room...

Shining light on neurosurgery diagnostics using Raman spectroscopy

Journal of Neuro-Oncology, 2016

Surgical excision of brain tumors provides a means of cytoreduction and diagnosis while minimizin... more Surgical excision of brain tumors provides a means of cytoreduction and diagnosis while minimizing neurologic deficit and improving overall survival. Despite advances in functional and three-dimensional stereotactic navigation and intraoperative magnetic resonance imaging, delineating tissue in real time with physiological confirmation is challenging. Raman spectroscopy is a promising investigative and diagnostic tool for neurosurgery, which provides rapid, non-destructive molecular characterization in vivo or in vitro for biopsy, margin assessment, or laboratory uses. The Raman Effect occurs when light temporarily changes a bond&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;s polarizability, causing change in the vibrational frequency, with a corresponding change in energy/wavelength of the scattered photon. The recorded inelastic scattering results in a &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot;fingerprint&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;quot; or Raman spectrum of the constituent under investigation. The amount, location, and intensity of peaks in the fingerprint vary based on the amount of vibrational bonds in a molecule and their ensemble interactions with each other. Distinct differences between various pathologic conditions are shown as different intensities of the same peak, or shifting of a peak based on the binding conformation. Raman spectroscopy has potential for integration into clinical practice, particularly in distinguishing normal and diseased tissue as an adjunct to standard pathologic diagnosis. Further, development of fiber-optic Raman probes that fit through the instrument port of a standard endoscope now allows researchers and clinicians to utilize spectroscopic information for evaluation of in vivo tissue. This review highlights the need for such an instrument, summarizes neurosurgical Raman work performed to date, and discusses the future applications of neurosurgical Raman spectroscopy.

Wide bandgap semiconductor waveguide structures

Microsystems arrays for digital radiation imaging and signal processing and method for making microsystem arrays

Raman Scattering Studies of Pb_1-x Srx TiO3 (x = 0 to 1.0) Films Grown by Metalorganic Decomposition (mod)

Pb_1-x Srx TiO3 (x = 0 to 1.0) films of thickness ˜ 4 mu m have been prepared on Pt substrates by... more Pb_1-x Srx TiO3 (x = 0 to 1.0) films of thickness ˜ 4 mu m have been prepared on Pt substrates by the metalorganic decomposition (MOD) technique. X-ray diffraction results show that the films are polycrystalline with a perovskite tetragonal phase at room temperature for x 0.6. Room temperature Raman spectra show a systematic variation of lattice vibrational modes with

Method and apparatus for activating molecules to stimulate neurological tissue

Static Interferometer with Step-Style Reflective Element

Stress-induced polarization-graded ferroelectrics

Applied Physics Letters, 2002

Dielectrics, piezoelectrics, and ferroelectrics and their properties. Dielectric thin films. Diel... more

Cubic (zinc-blend) aluminum nitride and method of making same

Anatase TiO2 films based CO gas sensor: Film thickness, substrate and temperature effects

Applied Surface Science, Aug 1, 2007

Electrical response of anatase TiO2 films is discussed for different concentrations of CO gas (20... more Electrical response of anatase TiO2 films is discussed for different concentrations of CO gas (20 100 ppm) in a nitrogen gas ambient. We investigated temperature (100 300 °C) and film thickness (100 1000 nm) effects for films deposited on glass, sapphire (0 0 0 1) and, Si(1 0 0) substrates. In general, there is a drop in resistance of the