Suriyan Sukati

Walailak University, Department of Medical Technology, School of Allied Health Sciences, Faculty Member

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Dr. Suriyan Sukati is an Assistant Professor in Medical Technology with expertise in the fields of hematology and medical technology. Dr. Sukati earned his Bachelor's degree with first-class honors in Medical Technology from Naresuan University and obtained a Ph.D. in Molecular Genetics and Genetic Engineering from the Institute of Molecular Biosciences at Mahidol University with The Royal Golden Jubilee Ph.D. Program Grant (RGJ). He then expanded his knowledge through a postdoctoral fellowship at the College of Medicine, University of Kentucky, USA.

Dr. Sukati has demonstrated interest and expertise in areas of hematology emphasizing the coagulation system, thrombosis, hemostasis, and extracellular vesicles for biomarker mechanisms of the hypercoagulation state. His research also includes the study of natural products that reduce thrombotic risk.

In addition to his academic achievements, Dr. Sukati has held the position of Director of Medical Technology (International Program), Department of Medical Technology, School of Allied Health Sciences, Walailak University from 2020 - 2024.

Dr. Sukati's contributions to the field of hematology and medical technology are evident through publications in various journals such as Scientific Reports, Brain Research, PLoS One, Redox Biology, Free Radical Biology and Medicine, Frontiers in Pharmacology, Frontiers in Immunology, Journal of Tropical Medicine, International Journal of Applied Pharmaceutics, The Scientific World Journal, International Journal of Pharmacological and Pharmaceutical Sciences, Journal of Applied Pharmaceutical Science, and Journal of Advanced Pharmaceutical Technology & Research, etc.
Address: 222 Walailak University, Thaiburi
School of Allied Health Sciences, Academic Building 7

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Assay of total calpastatin activity

The bar graph represents calpastatin activity in the sample groups. Calpastatin activity... more

Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis

D-dimer, a byproduct of cross-linked fibrin degradation, arises during the fibrinolysis process, ... more D-dimer, a byproduct of cross-linked fibrin degradation, arises during the fibrinolysis process, breaking down blood clots in circulation. This systematic review and meta-analysis aimed to synthesize evidence of D-dimer alteration in people with malaria, including variations in disease severity. The systematic review was registered in PROSPERO with registration number CRD42024528245. Searches were performed in EMBASE, Scopus, MEDLINE, PubMed, Nursing & Allied Health Premium, and Journals@ Ovid on March 25, 2024, to identify original studies that reported D-dimer in patients with Plasmodium infections. The methodological quality of the included studies was assessed using the Joanna Briggs Institute critical appraisal tools. Thematic synthesis and meta-analysis were carried out to synthesize the findings of the included studies. A total of 24 studies were included in the review out of 1,115 records identified. According to the evaluated studies, patients with Plasmodium infections had higher D-dimer levels. A meta-analytic evaluation of D-dimer levels between patients with and without Plasmodium infections revealed a significant elevation of D-dimer in patients with infection, with high heterogeneity (SMD = 2.11, 95% CI = 0.59; 3.64, P = 0.007, I² = 98%, 6 studies, 1,418 participants, random-effects model). However, no significant alterations in D-dimer levels were observed following the comparison between patients with severe and uncomplicated malaria, also with high heterogeneity (SMD = 2.54, 95% CI = -1.60; 6.68, P = 0.23, I² = 99%, 3 studies, 595 participants). The findings suggested that malaria patients have significantly higher D-dimer levels compared to nonmalarial individuals. However, there was no significant difference in D-dimer levels between severe and uncomplicated malaria cases. These results highlight the potential of D-dimer as a biomarker for Plasmodium infections, but its clinical utility requires further validation. Future studies should prioritize standardizing D-dimer measurement methods, including assay types, threshold values, and sample types, to ensure consistent and reliable application in clinical settings. Additionally, large, multicentric cohorts are needed to establish robust guidelines for incorporating D-dimer into malaria management practices. Further research should also explore the role of D-dimer in the pathogenesis of Plasmodium infections to deepen our understanding of their clinical significance.

Suriyan Sukati

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