Combined epithelial odontogenic tumors-fact or fallacy

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2007

European Journal of Cancer Part B: Oral Oncology, 1993

The combination of two odontogenic tumours is a rarely reported finding. To date only 10 cases of adenomatoid odontogenic tumour (AOT) combined with areas of calcifying epithelial odontogenic tumour (CEOT) have been published. This article describes the clinical, radiographical and microscopic findings of 12 cases of AOT, in which CEOT-like areas of variable sizes were found. These results suggest that such areas may be considered as a normal feature within the histomorphological spectrum of AOT.

Journal of Oral and Maxillofacial Surgery, 1986

The following is the third reported case of a combined epithelial odontogenic tumor, with the first two having been reported by Damm et al.' in May 1983. Report of Case A 14-year-old black girl presented with an asymptomatic swelling of the right face. She stat ed that she had been treated on at least two previous occasions by cos

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2002

European Journal of …, 1993

Oral Oncol, EurI Cancer, Yol. 29B, No. 3, pp. 221-224, 1993 Printed In Great Britain 0964-1955193 $6.00+0.00 Pergaman Press Ltd Adenomatoid Odontogenic Tumour with Features of Calcifying Epithelial Odontogenic Tumour. (The so-called Combined Epithelial Odontogenic ...

Journal of King Abdulaziz University-Medical Sciences, 2007

The combined epithelial odontogenic tumor is known to be an uncommon lesion characterized by the synchronous presentation of typical histological features of adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, or Pindborg tumor. Combination between other types of odontogenic tumors has occasionally been reported in the literature. In this work we report 2 cases of adenomatoid odontogenic tumor associated with odontomas, one in a 16-year-old male patient and the other in an 11-year-old female child. The 2 cases, with this type of combination, seem to be the first reported in the literature. In addition, we report a third case of association between calcifying epithelial odontogenic cyst or Gorlin cyst and ameloblastoma in a 14-year-old female patient. This case seems also to be the fourth case reported in the literature. The cases reported in this present work were evaluated clinically, radiographically, and histologically.

Background: Calcifying epithelial odontogenictumour (CEOT) also known as Pindborg's tumour is a relatively rare odontogenic neoplasm of epithelial derivation that constitutes about 0.4-3% of all intraosseousodontogenictumours. Objectives: The aim of this study was to document all cases of CEOT encountered in 5 tertiary centers in Nigeria and their clinical, radiologic and histologic characteristics. Design: A retrospective study. Setting: Tertiary Dental Facilities in Lagos, Ibadan, Ife, Port Harcourt and Zaria (all in Nigeria) were involved in the study. Subjects: All odontogenictumours (OTs) in the period from 1970-2014. Case file records and biopsy reports were retrieved from the records of the five Teaching Hospitals, to obtain age, gender, location, size, clinical symptoms, pathological reports and radiographic description. Results: Out of a total of 1369 OTs, 20 (1.5%) cases of CEOT were reported. CEOT had a male to female ratio of 1.9:1, with mandible: maxilla ratio of 1.5:1 and the most common location being the premolar /molar region in the mandible. Nine (45%) cases appeared radiolucent while 11(55%) cases had mixed radio density. The mean diameter for mixed radio-dense lesions (4.83±2.99) was higher than that for radiolucent lesions (2.75±1.17) and the difference was statistically significant (p=0.049). Conclusion: CEOT is a rare tumour representing 1.5% of OTs. CEOT presents with some subtle geographic differences in its demography, however, further studies are required to investigate if these differences are coincidental or genetically determined.

Journal of Oral and Maxillofacial Surgery, 2013

A calcifying epithelial odontogenic tumor (CEOT), also known as a Pindborg tumor, is a benign odontogenic neoplasm first described by the Danish pathologist, Dr Jens Pindborg, in 1955. 1 CEOT is an uncommon, locally aggressive tumor that accounts for 0.4% to 3% of all odontogenic tumors. Since 2004, approximately 200 cases of CEOT have been reported. Because the tumor is so rare, its biological characteristics have not been adequately studied. The authors present the case of a 50year-old woman with CEOT and the results of immunohistochemical and electron microscopic studies.

Head and Neck Pathology, 2012

Adenomatoid odontogenic tumor (AOT) is an uncommon benign epithelial lesion of odontogenic origin and, thus far, only few studies regarding the frequency of its many histopathologic features have been published in the literature. Thus, the aim of this study was to perform a retrospective analysis in a case series of AOT, with emphasis on the histopathological features. Fifteen cases of AOT were studied considering their clinical, radiographic and histopathologic aspects. Twelve cases affected females and the mean age was 16.2 years. The anterior maxilla was the most common site (66.6 %) and radiographically most cases showed a unilocular radiolucency with well-defined borders (57.1 %). Histologically, most cases exhibited predominantly a solid growth pattern (46.7 %) or a similar proportion of solid and cribriform patterns (46.7 %). Eosinophilic amorphous material (''tumor droplets'') was found in all cases (100 %). Most tumors showed duct-like spaces (93.3 %) and convoluted structures (60.0 %) whereas a minor proportion of cases presented calcifying epithelial odontogenic tumor (CEOT)-like areas (26.7 %). Variable amounts of calcified material were found in most AOTs (80.0 %) whereas osteodentin and perivascular hyalinization were seen only rarely (6.7 % each one). Five (33.3 %) cases had areas mimicking a dentigerous cyst and most of these were diagnosed in females (80.0 %). Regarding the histopathologic features, our results suggest that AOTs usually show predominance of solid pattern or a similar proportion of solid and cribriform patterns while osteodentin and perivascular hyalinization are rarely seen in these tumors. In addition, areas mimicking a dentigerous cyst and CEOT-like areas are relatively infrequent findings in AOTs.

Acta Cytologica, 2005

Calcifying epithelial odontogenic tumor (CEOT), or Pindborg's tumor, is a rare, benign, odontogenic neoplasm first described by Pindborg in 1955. It is most commonly seen in the fourth and fifth decades of life, usually arises in the mandibular premolarmolar areas and accounts for approximately 1% of all intraosseous odontogenic tumors. This report describes the cytologic findings in a case of CEOT. Case A 62-year-old woman was referred to the ear, nose and throat clinic with a right maxillary mass. The fine needle aspiration (FNA) smears showed numerous calcifications; amorphous, eosinophilic material; and clusters of round epithelial cells embedded in a bloody background. The smears were diagnosed as suspicious for malignancy. Maxillectomy was done. The histologic sections were diagnosed as CEOT. Conclusion FNA findings of calcifying epithelial odontogenic tumor have been described rarely. The clusters of epithelial cells with prominent nucleoli are mistaken for features of a malignant tumor. (Acta Cytol 2005;49:533-536)