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Academia Biology, 2024
The increasing complexity of biological systems demands advanced analytical approaches to decode the underlying mechanisms of health and disease. Integrative multi-omics approaches use multi-layered datasets such as genomic, transcriptomic, proteomic, and metabolomic data to understand biological processes much more comprehensively compared to the single-omics analysis and to provide a comprehensive view of cellular and molecular processes. However, these integrative approaches have their own computational and analytical challenges due to the large volume and nature of multi-omics data. Machine learning has emerged as a powerful tool to help and resolve these challenges. It offers sophisticated algorithms that can identify and discover hidden patterns and provide insights into complex biological networks. By integrating machine learning in multi-omics, we can enhance our understanding of drug discovery, disease, pathway, and network analysis. Machine learning and ensemble methods allow researchers to model nonlinear relationships and manage high-dimensional data, improving the precision of predictions. This approach paves the way for personalized medicine by identifying unique molecular signatures for individual patients, which can provide valuable insights into treatment planning and support more effective treatment. As machine learning continues to evolve, its role in multi-omics analysis will be pivotal in advancing our ability to interpret biological complexity and translate findings into clinical applications.
СОДЕРЖАНИЕ: С.Н. Беззаконов, М.И. Жих ДРЕВНЕЙШИЕ ИЗВЕСТИЯ О РУСАХ Sergey Bezzakonov, Maksim Zhikh OLDEST INFORMATION ABOUT THE RUS PEOPLE И.А. Гагин ДИАЛЕКТИЧЕСКИЙ МЕТОД А.Г. КУЗЬМИНА И «ИСТОРИЯ РОССИЙСКАЯ» В.Н. ТАТИЩЕВА Igor Gagin A.G. KUZMIN’S DIALECTICAL METHOD AND V.N. TATISHCHEV’S HISTORY OF RUSSIA Д.С. Логинов ЭТНИЧЕСКИЕ ПРОЦЕССЫ В РЯЗАНСКОМ ПООЧЬЕ В ЭПОХУ НЕОЛИТА Dmitry Loginov ETHNIC PROCESSES IN THE RYAZAN REGION IN THE NEOLITHIC ERA В.И. Кулаков ГЕРМАНСКИЙ РИТУАЛ ЭПОХИ МЕРОВИНГОВ – В ВОСТОЧНОЙ ЕВРОПЕ Vladimir Kulakov GERMANIC RITUAL OF THE MEROVINGIAN ERA IN EASTERN EUROPE С.Б. Чебаненко ВЕЧЕВОЕ ПРАВОСУДИЕ И МОТИВ МЕСТИ В КИЕВСКИХ СОБЫТИЯХ 1147 г.: СМЕРТЬ ИГОРЯ ОЛЬГОВИЧА Sergey Chebanenko VECHE JUSTICE AND THE MOTIVE OF REVENGE IN THE KIEV EVENTS OF 1147: THE DEATH OF IGOR OLGOVICH С.В. Томсинский НЕКОТОРЫЕ СПОРНЫЕ ВОПРОСЫ ИСТОРИИ УГЛИЧА: О ВОЗМОЖНЫХ ПРЕДПОСЫЛКАХ ПОЛЕМИКИ Sergey Tomsinsky SOME CONTROVERSIAL ISSUES OF THE HISTORY OF UGLICH: ON POSSIBLE BACKGROUND OF POLEMICS А.В. Парунин СПИСКИ СОЧИНЕНИЯ УТЕМИША-ХАДЖИ В ОЦЕНКЕ СОВРЕМЕННОЙ ИСТОРИОГРАФИИ Alexey Parunin MANUSCRIPT COPIES OF WORK BY UTEMISH HAJJI FROM THE POINT OF VIEW OF MODERN HISTORIOGRAPHY И.Ю. Васильев ТЕРРИТОРИАЛЬНЫЕ КОЛЛЕКТИВЫ ВЫЖИВАНИЯ КУБАНСКИХ КАЗАКОВ Igor Vasilyev TERRITORIAL SURVIVAL COLLECTIVES OF KUBAN COSSACKS С.Н. Азбелев НЕИЗДАННАЯ КРУПНЕЙШАЯ ЛЕТОПИСЬ ВЕЛИКОГО НОВГОРОДА КАК ИСТОРИЧЕСКИЙ ИСТОЧНИК И КАК ПАМЯТНИК ИСТОРИОГРАФИИ Sergey Azbelev THE UNPUBLISHED LARGEST CHRONICLE OF NOVGOROD THE GREAT AS A HISTORICAL SOURCE AND A HISTORIOGRAPHICAL MONUMENT М.И. Жих О НЕКОТОРЫХ ДИСКУССИОННЫХ ВОПРОСАХ ПОХОДА РУСОВ НА КОНСТАНТИНОПОЛЬ В 860 г. Maksim Zhikh SOME DEBATABLE ISSUES OF THE RUS’ CAMPAIGN TO CONSTANTINOPLE IN 860
[...] O assunto deste livro é a filosofia "moderna". Suponho, como outros, que a filosofia moderna tem início com Descartes, e que sua mais significativa manifestação recente possa ser encontrada nos escritos de Wittgenstein. Espero embasar tais suposições, mas meu principal objetivo será apresentar a história da filosofia 0ci- dental moderna de modo tão breve quanto possível. Desejo que o teor deste livro seja inteligível para os que não possuem conhecimento especializado de filosofia analítica contemporânea. Infelizmente, é muito difícil descrever breve- mente a natureza da filosofia; a única satisfação que um autor pode auferir da tentativa de fazê-lo está em saber que uma res- posta à questão "que é filosofia?" só pode parecer persuasiva na medida em que seja breve. Quanto mais se pondera acerca das restrições que qualquer resposta dada deve apresentar, mais se é impelido à conclusão de que tal questão constitui em si mesma o principal objeto da pesquisa filosófica. É claro que a descrição que agora faço da natureza da filosofia refletirá meu ponto de vista filosófico particular, e, aos olhos do leitor, seu mérito deve residir no fato de ter-se recomendado a um filósofo que é também seu contemporâneo. [...] "Que causou isso?" Provavelmente, uma resposta científica deve ser formulada em termos de eventos e condições precedentes, juntamente com certas leis ou hipóteses que articulem o evento a ser explicado com os eventos que o explicam. Entretanto, poderíamos fazer a mesma pergunta com relação a esses outros eventos e, caso se respondesse do mesmo modo, pelo menos potencialmente, as séries causais poderiam prolongar-se eternamente, regredindo ao infinito. Percebendo tal possibilidade, poderíamos ser levados a perguntar: "Que causou a existência das séries?", ou, ainda mais abstratamente, "Por que devem existir eventos?"; ou seja, não apenas por que deveria haver este ou aquele evento, mas por que existe alguma coisa? Naturalmente, a investigação científica que nos leva do que é dado ao que o explica pressupõe a existência de coisas. Consequentemente, ela não pode resolver essa questão mais abstrata e intrincada. [...] Excerto do Capítulo 1 do livro
This is the transcript of a two-hours conversation with HH the Dalai Lama, at a Mind & Life conference held in January 2013 at Drepung monastery (South India). Its central claim is that quantum mechanics, and even science in general, becomes much clearer as soon as one understands that its explanations are given in terms of relations rather than in terms of absolute properties. It addresses several well-known paradoxes of quantum mechanics, and shows that they dissolve straightaway when one realizes that this theory does not provide us with a representation of the world, but a user’s manual for the network of relations we establish within this world.
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