| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Shrek Forever After | $57,060,434 | - | 4,367 | - | $13,066 | $146,810,785 | 2 | DreamWorks | false | false |
| 2 | - | Prince of Persia: The Sands of Time | $37,813,075 | - | 3,646 | - | $10,371 | $37,813,075 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 3 | - | Sex and the City 2 | $36,835,353 | - | 3,445 | - | $10,692 | $51,043,450 | 1 | Warner Bros. | true | false |
| 4 | - | Iron Man 2 | $21,076,239 | - | 3,804 | - | $5,540 | $279,653,149 | 4 | Paramount Pictures | false | false |
| 5 | - | Robin Hood | $13,424,540 | - | 3,373 | - | $3,980 | $86,144,405 | 3 | Universal Pictures | false | false |
| 6 | - | Letters to Juliet | $7,492,524 | - | 2,825 | - | $2,652 | $38,195,942 | 3 | Summit Entertainment | false | false |
| 7 | - | Just Wright | $2,835,702 | - | 1,195 | - | $2,372 | $18,833,220 | 3 | - | false | false |
| 8 | - | Date Night | $2,307,657 | - | 1,126 | - | $2,049 | $94,005,365 | 8 | Twentieth Century Fox | false | false |
| 9 | - | MacGruber | $2,024,110 | - | 2,546 | - | $795 | $7,674,445 | 2 | Universal Pictures | false | false |
| 10 | - | How to Train Your Dragon | $1,513,677 | - | 825 | - | $1,834 | $213,117,896 | 10 | DreamWorks | false | false |
| 11 | - | A Nightmare on Elm Street | $1,127,395 | - | 891 | - | $1,265 | $61,906,422 | 5 | Warner Bros. | false | false |
| 12 | - | Alice in Wonderland | $730,145 | - | 341 | - | $2,141 | $333,160,345 | 13 | Walt Disney Studios Motion Pictures | false | false |
| 13 | - | Babies | $642,273 | - | 301 | - | $2,133 | $6,090,771 | 4 | Focus Features | false | false |
| 14 | - | The Secret in Their Eyes | $577,670 | - | 155 | - | $3,726 | $3,452,774 | 7 | Sony Pictures Classics | false | false |
| 15 | - | City Island | $532,862 | - | 201 | - | $2,651 | $4,862,137 | 11 | Anchor Bay Films | false | false |
| 16 | - | The Girl with the Dragon Tattoo | $502,055 | - | 166 | - | $3,024 | $6,938,569 | 11 | Music Box Films | false | false |
| 17 | - | Hubble | $423,169 | - | 48 | - | $8,816 | $7,104,630 | 11 | Warner Bros. | false | false |
| 18 | - | The Back-up Plan | $359,677 | - | 391 | - | $919 | $36,594,990 | 6 | CBS Films | false | false |
| 19 | - | The Bounty Hunter | $354,260 | - | 287 | - | $1,234 | $65,652,479 | 11 | Sony Pictures Releasing | false | false |
| 20 | - | Diary of a Wimpy Kid | $335,000 | - | 283 | - | $1,183 | $62,769,868 | 11 | Twentieth Century Fox | false | false |
| 21 | - | Kites | $315,016 | - | 176 | - | $1,789 | $1,497,645 | 2 | Reliance Big Pictures | false | false |
| 22 | - | Death at a Funeral | $290,528 | - | 247 | - | $1,176 | $41,945,596 | 7 | Screen Gems | false | false |
| 23 | - | Hot Tub Time Machine | $285,782 | - | 364 | - | $785 | $50,007,104 | 10 | Metro-Goldwyn-Mayer (MGM) | false | false |
| 24 | - | Clash of the Titans | $278,708 | - | 225 | - | $1,238 | $161,379,503 | 9 | Warner Bros. | false | false |
| 25 | - | Please Give | $255,836 | - | 50 | - | $5,116 | $1,395,290 | 5 | Sony Pictures Classics | false | false |
| 26 | - | The Last Song | $247,405 | - | 214 | - | $1,156 | $61,971,248 | 9 | Walt Disney Studios Motion Pictures | false | false |
| 27 | - | Exit Through the Gift Shop | $241,171 | - | 46 | - | $5,242 | $1,950,348 | 7 | - | false | false |
| 28 | - | Furry Vengeance | $217,303 | - | 247 | - | $879 | $16,501,858 | 5 | Summit Entertainment | false | false |
| 29 | - | Shutter Island | $202,436 | - | 201 | - | $1,007 | $127,845,041 | 15 | Paramount Pictures | false | false |
| 30 | - | Kick-Ass | $198,960 | - | 163 | - | $1,220 | $47,508,227 | 7 | Lionsgate | false | false |
| 31 | - | Oceans | $174,685 | - | 178 | - | $981 | $18,910,083 | 6 | Walt Disney Studios Motion Pictures | false | false |
| 32 | - | Harry Brown | $168,860 | - | 54 | - | $3,127 | $1,066,758 | 5 | The Samuel Goldwyn Company | false | false |
| 33 | - | Why Did I Get Married Too? | $150,708 | - | 177 | - | $851 | $59,982,629 | 9 | Lionsgate | false | false |
| 34 | - | Avatar | $144,241 | - | 84 | - | $1,717 | $749,073,100 | 24 | Twentieth Century Fox | false | false |
| 35 | - | Princess Kaiulani | $122,396 | - | 38 | - | $3,220 | $626,985 | 3 | Roadside Attractions | false | false |
| 36 | - | The Losers | $119,149 | - | 83 | - | $1,435 | $23,247,269 | 6 | Warner Bros. | false | false |
| 37 | - | Solitary Man | $110,531 | - | 6 | - | $18,421 | $243,087 | 2 | Anchor Bay Films | false | false |
| 38 | - | The Ghost Writer | $92,981 | - | 58 | - | $1,603 | $15,331,639 | 15 | Summit Entertainment | false | false |
| 39 | - | Percy Jackson & the Olympians: The Lightning Thief | $82,957 | - | 108 | - | $768 | $88,603,078 | 16 | Twentieth Century Fox | false | false |
| 40 | - | Mother and Child | $72,226 | - | 33 | - | $2,188 | $336,545 | 4 | Sony Pictures Classics | false | false |
| 41 | - | Holy Rollers | $71,955 | - | 20 | - | $3,597 | $126,085 | 2 | First Independent Pictures | false | false |
| 42 | - | Under the Sea 3D | $64,014 | - | 18 | - | $3,556 | $22,231,251 | 68 | Warner Bros. | false | false |
| 43 | - | Survival of the Dead | $54,605 | - | 20 | - | $2,730 | $54,605 | 1 | Magnolia Pictures | true | false |
| 44 | - | Micmacs | $51,914 | - | 4 | - | $12,978 | $51,914 | 1 | Sony Pictures Classics | true | false |
| 45 | - | La Mission | $44,446 | - | 25 | - | $1,777 | $863,332 | 8 | Screen Media Films | false | false |
| 46 | - | Agora | $44,313 | - | 2 | - | $22,156 | $44,313 | 1 | Newmarket Films | true | false |
| 47 | - | Father of My Children | $42,538 | - | 5 | - | $8,507 | $56,024 | 2 | IFC Films | false | false |
| 48 | - | Breathless 2010 Re-release | $41,449 | - | 4 | - | $10,362 | $41,449 | 1 | Rialto Pictures | true | false |
| 49 | - | Tooth Fairy | $41,162 | - | 76 | - | $541 | $59,965,649 | 19 | Twentieth Century Fox | false | false |
| 50 | - | The Secret of Kells | $34,503 | - | 25 | - | $1,380 | $541,971 | 13 | GKIDS | false | false |
| 51 | - | Our Family Wedding | $32,047 | - | 52 | - | $616 | $20,217,845 | 12 | - | false | false |
| 52 | - | Magnificent Desolation: Walking on the Moon | $31,231 | - | 5 | - | $6,246 | $32,995,119 | 245 | IMAX | false | false |
| 53 | - | Kites The Remix | $31,191 | - | 40 | - | $779 | $31,191 | 1 | Reliance Big Pictures | true | false |
| 54 | - | The City of Your Final Destination | $28,954 | - | 14 | - | $2,068 | $290,993 | 7 | Screen Media Films | false | false |
| 55 | - | Casino Jack and the United States of Money | $27,977 | - | 21 | - | $1,332 | $136,691 | 4 | Magnolia Pictures | false | false |
| 56 | - | Mid-August Lunch | $27,659 | - | 12 | - | $2,304 | $456,592 | 11 | Zeitgeist Films | false | false |
| 57 | - | Mademoiselle Chambon | $25,595 | - | 2 | - | $12,797 | $25,595 | 1 | Lorber Films | true | false |
| 58 | - | Only the Brave | $22,135 | - | 5 | - | $4,427 | $65,200 | 1 | Indican Pictures | true | false |
| 59 | - | Deep Sea | $21,674 | - | 2 | - | $10,837 | $43,309,262 | 222 | Warner Bros. | false | false |
| 60 | - | The Square 2010 Re-release | $21,307 | - | 15 | - | $1,420 | $288,731 | 8 | Apparition | false | false |
| 61 | - | The Cremaster Cycle 2010 Re-release | $15,547 | - | 1 | - | $15,547 | $52,679 | 8 | International Film Circuit | false | false |
| 62 | - | The Human Centipede (First Sequence) | $14,216 | - | 14 | - | $1,015 | $135,962 | 5 | IFC Films | false | false |
| 63 | - | Mother | $12,263 | - | 12 | - | $1,021 | $526,453 | 12 | Magnolia Pictures | false | false |
| 64 | - | The Good the Bad the Weird | $11,522 | - | 13 | - | $886 | $101,773 | 6 | IFC Films | false | false |
| 65 | - | Metropolis 2010 Re-release | $11,327 | - | 2 | - | $5,663 | $138,876 | 4 | Kino International | false | false |
| 66 | - | A Prophet | $10,296 | - | 14 | - | $735 | $2,063,520 | 14 | Sony Pictures Classics | false | false |
| 67 | - | Chloe | $9,945 | - | 18 | - | $552 | $3,014,592 | 10 | Sony Pictures Classics | false | false |
| 68 | - | Vincere | $9,810 | - | 12 | - | $817 | $590,978 | 11 | IFC Films | false | false |
| 69 | - | Looking for Eric | $9,244 | - | 8 | - | $1,155 | $34,035 | 3 | IFC Films | false | false |
| 70 | - | Sea Monsters: A Prehistoric Adventure | $8,755 | - | 6 | - | $1,459 | $23,196,718 | 139 | National Geographic Entertainment | false | false |
| 71 | - | Two in the Wave | $7,332 | - | 1 | - | $7,332 | $20,760 | 2 | Lorber Films | false | false |
| 72 | - | 180° South | $6,645 | - | 4 | - | $1,661 | $24,206 | 2 | Magnolia Pictures | false | false |
| 73 | - | Racing Dreams | $6,133 | - | 8 | - | $766 | $29,409 | 2 | Hannover House | false | false |
| 74 | - | Best Worst Movie | $5,852 | - | 2 | - | $2,926 | $41,146 | 6 | Abramorama | false | false |
| 75 | - | Letters to God | $5,229 | - | 14 | - | $373 | $2,838,982 | 8 | Vivendi Entertainment | false | false |
| 76 | - | John Rabe | $5,199 | - | 4 | - | $1,299 | $12,824 | 2 | Strand Releasing | false | false |
| 77 | - | The Eclipse | $5,115 | - | 5 | - | $1,023 | $119,377 | 10 | Magnolia Pictures | false | false |
| 78 | - | OSS 117: Lost in Rio | $5,105 | - | 3 | - | $1,701 | $49,866 | 4 | Music Box Films | false | false |
| 79 | - | The Runaways | $4,278 | - | 11 | - | $388 | $3,571,735 | 11 | Apparition | false | false |
| 80 | - | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | $4,276 | - | 5 | - | $855 | $445,948 | 18 | First Run | false | false |
| 81 | - | The Joneses | $3,807 | - | 8 | - | $475 | $1,435,754 | 7 | Roadside Attractions | false | false |
| 82 | - | No One Knows About Persian Cats | $3,681 | - | 7 | - | $525 | $69,633 | 7 | IFC Films | false | false |
| 83 | - | Touching Home | $3,630 | - | 2 | - | $1,815 | $96,578 | 5 | CFI Releasing | false | false |
| 84 | - | Crazy Heart | $3,563 | - | 7 | - | $509 | $39,462,438 | 24 | - | false | false |
| 85 | - | Sweetgrass | $3,517 | - | 3 | - | $1,172 | $164,101 | 21 | The Cinema Guild | false | false |
| 86 | - | Daddy Longlegs | $2,517 | - | 2 | - | $1,258 | $20,728 | 3 | IFC Films | false | false |
| 87 | - | Beetle Queen Conquers Tokyo | $2,387 | - | 2 | - | $1,193 | $19,588 | 3 | Argot Pictures | false | false |
| 88 | - | Prodigal Sons | $2,220 | - | 1 | - | $2,220 | $72,618 | 14 | First Run | false | false |
| 89 | - | Ajami | $2,111 | - | 2 | - | $1,055 | $587,401 | 17 | Kino International | false | false |
| 90 | - | After the Cup: Sons of Sakhnin United | $1,840 | - | 2 | - | $920 | $5,507 | 2 | Variance Films | false | false |
| 91 | - | House | $1,624 | - | 2 | - | $812 | $134,023 | 20 | Janus Films | false | false |
| 92 | - | Valley of the Heart's Delight | $1,237 | - | 1 | - | $1,237 | $116,740 | 8 | Indican Pictures | false | false |
| 93 | - | Dancing Across Borders | $1,022 | - | 1 | - | $1,022 | $59,912 | 10 | First Run | false | false |
| 94 | - | Behind the Burly Q | $900 | - | 1 | - | $900 | $15,516 | 6 | First Run | false | false |
| 95 | - | Space Station 3D | $849 | - | 2 | - | $424 | $81,949,989 | 424 | IMAX | false | false |
| 96 | - | U2 3D | $592 | - | 1 | - | $592 | $10,329,092 | 123 | National Geographic Entertainment | false | false |
| 97 | - | Here and There | $568 | - | 4 | - | $142 | $15,797 | - | Cinema Purgatorio | - | false |
| 98 | - | October Country | $541 | - | 1 | - | $541 | $22,636 | 16 | International Film Circuit | false | false |
| 99 | - | The Last Station | $534 | - | 3 | - | $178 | $6,606,852 | 20 | Sony Pictures Classics | false | false |
| 100 | - | The Girl on the Train | $457 | - | 2 | - | $228 | $201,795 | 19 | Strand Releasing | false | false |
| 101 | - | Small Change | $448 | - | 1 | - | $448 | $28,396 | - | The Film Desk | - | false |
| 102 | - | The White Ribbon | $245 | - | 1 | - | $245 | $2,222,647 | 22 | Sony Pictures Classics | false | false |
| 103 | - | Promised Lands | $52 | - | 1 | - | $52 | $3,690 | - | The Film Desk | - | false |
