| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The Twilight Saga: Eclipse | $83,637,242 | - | 4,468 | - | $18,719 | $176,382,220 | 1 | Summit Entertainment | true | false |
| 2 | - | The Last Airbender | $51,804,232 | - | 3,169 | - | $16,347 | $69,315,329 | 1 | Paramount Pictures | true | false |
| 3 | - | Toy Story 3 | $43,057,129 | - | 4,028 | - | $10,689 | $301,883,298 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 4 | - | Grown Ups | $26,052,792 | - | 3,534 | - | $7,372 | $84,634,307 | 2 | Sony Pictures Releasing | false | false |
| 5 | - | Knight and Day 2010 Re-release | $14,151,734 | - | 3,104 | - | $4,559 | $49,460,348 | 2 | Twentieth Century Fox | false | false |
| 6 | - | The Karate Kid | $11,031,522 | - | 3,109 | - | $3,548 | $154,554,780 | 4 | Sony Pictures Releasing | false | false |
| 7 | - | The A-Team | $4,403,057 | - | 2,153 | - | $2,045 | $70,494,007 | 4 | Twentieth Century Fox | false | false |
| 8 | - | Get Him to the Greek | $1,723,840 | - | 884 | - | $1,950 | $57,965,435 | 5 | Universal Pictures | false | false |
| 9 | - | Shrek Forever After | $1,275,957 | - | 957 | - | $1,333 | $232,664,432 | 7 | DreamWorks | false | false |
| 10 | - | Cyrus | $1,094,111 | - | 77 | - | $14,209 | $1,811,985 | 3 | - | false | false |
| 11 | - | Letters to Juliet | $972,374 | - | 340 | - | $2,859 | $51,094,679 | 8 | Summit Entertainment | false | false |
| 12 | - | Prince of Persia: The Sands of Time | $884,816 | - | 600 | - | $1,474 | $88,338,986 | 6 | Walt Disney Studios Motion Pictures | false | false |
| 13 | - | Iron Man 2 | $875,834 | - | 522 | - | $1,677 | $308,530,297 | 9 | Paramount Pictures | false | false |
| 14 | - | I Am Love | $722,544 | - | 80 | - | $9,031 | $1,290,480 | 3 | Magnolia Pictures | false | false |
| 15 | - | Solitary Man | $657,233 | - | 176 | - | $3,734 | $2,916,412 | 7 | Anchor Bay Films | false | false |
| 16 | - | Killers | $628,261 | - | 727 | - | $864 | $45,323,590 | 5 | Lionsgate | false | false |
| 17 | - | Winter's Bone | $599,597 | - | 83 | - | $7,224 | $1,881,488 | 4 | Roadside Attractions | false | false |
| 18 | - | Sex and the City 2 | $528,330 | - | 355 | - | $1,488 | $94,223,099 | 6 | Warner Bros. | false | false |
| 19 | - | Marmaduke | $483,697 | - | 475 | - | $1,018 | $30,939,738 | 5 | Twentieth Century Fox | false | false |
| 20 | - | How to Train Your Dragon | $481,505 | - | 303 | - | $1,589 | $216,296,739 | 15 | DreamWorks | false | false |
| 21 | - | Joan Rivers: A Piece of Work | $455,440 | - | 111 | - | $4,103 | $1,604,877 | 4 | IFC Films | false | false |
| 22 | - | Robin Hood | $449,745 | - | 378 | - | $1,189 | $104,034,820 | 8 | Universal Pictures | false | false |
| 23 | - | I Hate Luv Storys | $448,502 | - | 85 | - | $5,276 | $535,273 | 1 | UTV Motion Pictures | true | false |
| 24 | - | Hubble | $345,523 | - | 52 | - | $6,644 | $9,774,536 | 16 | Warner Bros. | false | false |
| 25 | - | The Girl with the Dragon Tattoo | $269,706 | - | 109 | - | $2,474 | $9,086,440 | 16 | Music Box Films | false | false |
| 26 | - | Date Night | $250,435 | - | 242 | - | $1,034 | $97,697,723 | 13 | Twentieth Century Fox | false | false |
| 27 | - | The Secret in Their Eyes | $240,617 | - | 127 | - | $1,894 | $5,662,489 | 12 | Sony Pictures Classics | false | false |
| 28 | - | Please Give | $233,476 | - | 145 | - | $1,610 | $3,498,143 | 10 | Sony Pictures Classics | false | false |
| 29 | - | Splice 2010 Re-release | $200,491 | - | 140 | - | $1,432 | $16,571,701 | 5 | Warner Bros. | false | false |
| 30 | - | Coco Chanel & Igor Stravinsky | $177,208 | - | 43 | - | $4,121 | $480,233 | 4 | Sony Pictures Classics | false | false |
| 31 | - | Jonah Hex | $164,259 | - | 350 | - | $469 | $9,978,085 | 3 | Warner Bros. | false | false |
| 32 | - | Clash of the Titans | $154,391 | - | 175 | - | $882 | $162,955,464 | 14 | Warner Bros. | false | false |
| 33 | - | City Island | $149,420 | - | 81 | - | $1,844 | $6,365,196 | 16 | Anchor Bay Films | false | false |
| 34 | - | Death at a Funeral | $144,894 | - | 136 | - | $1,065 | $42,739,347 | 12 | Screen Gems | false | false |
| 35 | - | Furry Vengeance | $118,989 | - | 107 | - | $1,112 | $17,489,464 | 10 | Summit Entertainment | false | false |
| 36 | - | Micmacs | $84,464 | - | 50 | - | $1,689 | $853,095 | 6 | Sony Pictures Classics | false | false |
| 37 | - | Exit Through the Gift Shop | $82,393 | - | 31 | - | $2,657 | $2,792,148 | 12 | - | false | false |
| 38 | - | Mother and Child | $82,270 | - | 77 | - | $1,068 | $934,414 | 9 | Sony Pictures Classics | false | false |
| 39 | - | Restrepo | $82,088 | - | 10 | - | $8,208 | $142,711 | 2 | National Geographic Entertainment | false | false |
| 40 | - | Harry Brown | $74,635 | - | 45 | - | $1,658 | $1,704,115 | 10 | The Samuel Goldwyn Company | false | false |
| 41 | - | Just Wright | $72,963 | - | 95 | - | $768 | $21,329,433 | 8 | - | false | false |
| 42 | - | The Back-up Plan | $68,902 | - | 97 | - | $710 | $37,375,686 | 11 | CBS Films | false | false |
| 43 | - | Ondine | $68,688 | - | 38 | - | $1,807 | $362,149 | 5 | Magnolia Pictures | false | false |
| 44 | - | The Bounty Hunter | $67,129 | - | 67 | - | $1,001 | $67,061,228 | 16 | Sony Pictures Releasing | false | false |
| 45 | - | Under the Sea 3D | $63,302 | - | 13 | - | $4,869 | $22,703,088 | 73 | Warner Bros. | false | false |
| 46 | - | Love Ranch | $60,353 | - | 11 | - | $5,486 | $74,776 | 1 | - | true | false |
| 47 | - | The Killer Inside Me | $60,251 | - | 17 | - | $3,544 | $110,808 | 3 | IFC Films | false | false |
| 48 | - | Oceans | $58,708 | - | 79 | - | $743 | $19,361,893 | 11 | Walt Disney Studios Motion Pictures | false | false |
| 49 | - | Diary of a Wimpy Kid | $56,434 | - | 70 | - | $806 | $63,803,221 | 16 | Twentieth Century Fox | false | false |
| 50 | - | A Nightmare on Elm Street | $53,403 | - | 110 | - | $485 | $63,005,877 | 10 | Warner Bros. | false | false |
| 51 | - | Magnificent Desolation: Walking on the Moon | $52,078 | - | 2 | - | $26,039 | $33,287,279 | 250 | IMAX | false | false |
| 52 | - | Babies | $50,193 | - | 42 | - | $1,195 | $7,291,384 | 9 | Focus Features | false | false |
| 53 | - | South of the Border | $45,951 | - | 6 | - | $7,658 | $76,159 | 2 | Cinema Libre Studio | false | false |
| 54 | - | The Last Song | $45,700 | - | 79 | - | $578 | $62,884,422 | 14 | Walt Disney Studios Motion Pictures | false | false |
| 55 | - | Wild Grass | $39,736 | - | 6 | - | $6,622 | $106,416 | 2 | Sony Pictures Classics | false | false |
| 56 | - | Avatar | $35,706 | - | 9 | - | $3,967 | $749,603,864 | 29 | Twentieth Century Fox | false | false |
| 57 | - | The City of Your Final Destination | $22,628 | - | 14 | - | $1,616 | $441,410 | 12 | Screen Media Films | false | false |
| 58 | - | Let it Rain | $16,796 | - | 5 | - | $3,359 | $66,659 | 3 | IFC Films | false | false |
| 59 | - | Holy Rollers | $15,416 | - | 13 | - | $1,185 | $283,591 | 7 | First Independent Pictures | false | false |
| 60 | - | Raavan | $15,262 | - | 28 | - | $545 | $705,704 | 3 | Reliance Big Pictures | false | false |
| 61 | - | Deep Sea | $13,729 | - | 2 | - | $6,864 | $43,414,429 | 227 | Warner Bros. | false | false |
| 62 | - | The Secret of Kells | $13,248 | - | 14 | - | $946 | $658,435 | 18 | GKIDS | false | false |
| 63 | - | Raajneeti | $11,003 | - | 11 | - | $1,000 | $1,510,687 | 5 | UTV Motion Pictures | false | false |
| 64 | - | Mid-August Lunch | $9,050 | - | 9 | - | $1,005 | $592,295 | 16 | Zeitgeist Films | false | false |
| 65 | - | Agora | $8,160 | - | 2 | - | $4,080 | $206,893 | 6 | Newmarket Films | false | false |
| 66 | - | La Mission | $7,767 | - | 5 | - | $1,553 | $1,010,617 | 13 | Screen Media Films | false | false |
| 67 | - | The Square 2010 Re-release | $7,379 | - | 5 | - | $1,475 | $394,562 | 13 | Apparition | false | false |
| 68 | - | Princess Kaiulani | $7,379 | - | 5 | - | $1,475 | $838,308 | 8 | Roadside Attractions | false | false |
| 69 | - | The Nature of Existence | $7,265 | - | 1 | - | $7,265 | $11,274 | 3 | Walking Shadows | false | false |
| 70 | - | Alice in Wonderland | $6,640 | - | 23 | - | $288 | $334,185,206 | 18 | Walt Disney Studios Motion Pictures | false | false |
| 71 | - | Stonewall Uprising | $6,075 | - | 4 | - | $1,518 | $68,284 | 3 | First Run | false | false |
| 72 | - | Breathless 2010 Re-release | $5,875 | - | 2 | - | $2,937 | $169,530 | 6 | Rialto Pictures | false | false |
| 73 | - | Only the Brave | $5,787 | - | 1 | - | $5,787 | $141,184 | 6 | Indican Pictures | false | false |
| 74 | - | Sea Monsters: A Prehistoric Adventure | $4,350 | - | 3 | - | $1,450 | $23,240,080 | 144 | National Geographic Entertainment | false | false |
| 75 | - | Best Worst Movie | $4,350 | - | 1 | - | $4,350 | $63,601 | 11 | Abramorama | false | false |
| 76 | - | Everyone Else | $4,204 | - | 3 | - | $1,401 | $73,396 | 13 | The Cinema Guild | false | false |
| 77 | - | The Lottery | $4,098 | - | 2 | - | $2,049 | $42,615 | 4 | Variance Films | false | false |
| 78 | - | The Sun Behind the Clouds: Tibet's Struggle for Freedom | $3,907 | - | 4 | - | $976 | $60,134 | - | Balcony Releasing | - | false |
| 79 | - | Rosencrantz and Guildenstern Are Undead | $3,608 | - | 1 | - | $3,608 | $40,123 | 5 | Indican Pictures | false | false |
| 80 | - | The Joneses | $3,581 | - | 1 | - | $3,581 | $1,470,569 | 12 | Roadside Attractions | false | false |
| 81 | - | OSS 117: Lost in Rio | $3,260 | - | 3 | - | $1,086 | $81,871 | 9 | Music Box Films | false | false |
| 82 | - | Kings of the Evening | $3,242 | - | 1 | - | $3,242 | $79,389 | 4 | Indican Pictures | false | false |
| 83 | - | Only When I Dance | $2,923 | - | 1 | - | $2,923 | $2,923 | 1 | Film Movement | true | false |
| 84 | - | Sweetgrass | $2,658 | - | 4 | - | $664 | $194,507 | 26 | The Cinema Guild | false | false |
| 85 | - | Racing Dreams | $2,494 | - | 3 | - | $831 | $49,344 | 7 | Hannover House | false | false |
| 86 | - | Survival of the Dead | $2,444 | - | 4 | - | $611 | $97,778 | 6 | Magnolia Pictures | false | false |
| 87 | - | Casino Jack and the United States of Money | $2,287 | - | 7 | - | $326 | $175,604 | 9 | Magnolia Pictures | false | false |
| 88 | - | Cropsey | $1,619 | - | 3 | - | $539 | $27,999 | 5 | Cinema Purgatorio | false | false |
| 89 | - | John Rabe | $1,376 | - | 2 | - | $688 | $46,338 | 7 | Strand Releasing | false | false |
| 90 | - | Chloe | $1,245 | - | 3 | - | $415 | $3,073,824 | 15 | Sony Pictures Classics | false | false |
| 91 | - | A Town Called Panic | $958 | - | 1 | - | $958 | $162,582 | 29 | Zeitgeist Films | false | false |
| 92 | - | Small Change | $568 | - | 1 | - | $568 | $29,612 | 32 | The Film Desk | false | false |
| 93 | - | Behind the Burly Q | $541 | - | 1 | - | $541 | $16,657 | 11 | First Run | false | false |
| 94 | - | Space Station 3D | $484 | - | 4 | - | $121 | $81,960,047 | 429 | IMAX | false | false |
| 95 | - | U2 3D | $346 | - | 1 | - | $346 | $10,335,544 | 128 | National Geographic Entertainment | false | false |
| 96 | - | Breath Made Visible: Anna Halprin | $155 | - | 1 | - | $155 | $50,398 | 14 | Argot Pictures | false | false |
