AurKa Pharma was established as part of the TVM Life Science Ventures VII fund, to develop an Aurora kinase A inhibitor called AK-01, an oncology compound that was originally discovered through a Lilly research and development program.
The compound is a potential first-in-class asset that
AurKa Pharma is studying in Phase 1 clinical trials in multiple types of solid tumors.
Prostate cancer with Paneth cell--like neuroendocrine differentiation has recognizable histomorphology and harbors
AURKA gene amplification.
The resulting analysis identified 18 genes - some such as
AURKA, UBE2C, TPX2, FAM83D, ZNF217, SALL4 and MMP9 have been previously known to potentially cause cancer.
Hizkuntza atzerritarren menpean zapalduta galbidean aurkitzen den une hontan, iraultzaile batentzat lehenengo eginkizuna nazio hizkuntzaren alde burrukatzea dela zapaltzaile guztien
aurka, eta ez gure artean [...] (8).
(Yorkshire) (2012) 17 Composite population
AURKA, Schneider et al.
Brief scores Group C: South Africa 293-6, 50 overs (Yaseen Valli 102 not out, Kirwin Christoffels 57, Bradley Dial 47, Aiden Markram 31, Bradley Bopp 20; Nikhil Dutta 3-54) beat Canada 248-8, 50 overs (Sudeepta
Aurka 69, Nitish Kumar 53, Nikhil Dutta 35; Yaseen Vali 4-43, Sibonelo Makhanya 3-42).
Canada's top-order batsmen kept them in the game after openers Sudeepta
Aurka (69) and Yug Rao (23) provided them with a good start.
The Aurora-A is encoded by the
AURKA gene (also known as AIK, Aurora/IPL1-like kinase; ARK1, Aurora related kinase 1; AURA, AURORA2; BTAK, breast tumoramplified kinase; PPP1R47, protein phosphatase 1 regulatory subunit 47; STK15, serine/threonine-protein kinase 15; STK6, serine/threonine kinase 6), located at 20q13.2 and consisting of 11 exons (Gene ID: 6790).
The resulting cDNA was subjected to SYBR green real-time PCR to investigate the differential expression of PLK1 interacting genes including
AURKA, PSMB5, MDM2, PKMYT, CHUK, and CDK1.
and Europe concluded that the majority of neuroendocrine prostate cancers significantly overexpressed
AURKA and MYCN genes, and 40 percent of these tumours also had extra copies of these genes.
KARACHI -- The much anticipated drama serial 'Main Khayal Hoon Kisi
AurKa' starring Hareem Farooq and Ali Rehman Khan in lead roles is all set to be aired from Saturday [June 23rd] at 8pm on Hum TV.
M2 EQUITYBITES-May 14, 2018-Lilly to Acquire Oncology Drug Developer
AurKa Pharma
