Effect of miR-142-3p overexpression on
Cox-2 expression on MLE-12 cells challenged by bleomycin
To find out the expression of
COX-2 enzyme by immunohistochemistry in malignant tumours of colorectal cancer in North India.
Considering the important roles that VEGF and
COX-2 play in angiogenesis and their contribution to the formation, growth, progression, and metastasis of tumors, it has been theorized that the expression of these two factors might be related to greater size and/ or aggressiveness of laryngeal and hypopharyngeal cancer tumors.
Immunohistochemistry Analysis for the Expressions of
COX-2 and VEGF in Eyes.
There are two isoforms of cyclooxygenase (Williams et al., 1999), COX-1 is mainly involved in the production of prostaglandins and is constitutively produced (Williams et al., 1999) while
COX-2 gene is only constitutively produced in kidneys, central nervous system and seminal vesicles, while in most of the cases it is inducible and being produced during ovulation, inflammation in cancers, anti-apoptotic activities, angiogenesis and immune suppression (Cha and DuBois, 2007).
It was observed that in patients on high dose warfarin therapy increased
COX-2 caused stimulation of IL-6.
Immunohistochemistry was performed using a primary rabbit monoclonal anti-human
COX-2 antibody (SP21, 1 : 20, Lab Vision, Freemont, CA), as described by LAVALLE et al.
The extracellular inducible factors of
COX-2 include growth factors, tumor promoters, cytokines, hypoxia, ionizing radiation and carcinogens (Singh, 2002; Howe, 2003; Wang, 2004).
Conclusion:
COX-2, GLUT-1 and VEGF were highly prominent in endometrial cancer, especially in the patients with low degree of differentiation, late stage and metastasis.
"While newer versions of
COX-2 drugs have been pulled from shelves, older ones are still frequently prescribed," said study author Dr.
The comprehensive epidemiological observations have demonstrated that daily use of NSAIDs or cyclooxygenase-2 (
COX-2) selective inhibitors can reduce the risk of colorectal cancer (Arber et al.
NSAIDs work by inhibiting cyclooxygenase, COX-1 and
COX-2, enzymes, which cause inflammation.
Instead, the scientists found, this particular lncRNA acts as an on/off switch for a key gene whose excessive activity is tied to inflammation and cancer,
COX-2.
(5) In the CV system, prostacyclin is synthesized by
COX-2. Prostacyclin plays a major role in the maintenance of cardiovascular homeostasis; prostacyclin also contributes to the inhibition of thrombosis when functioning as a platelet-aggregation inhibitor and potent vasodilator.
The
COX-2 enzymatic product, [PGE.sub.2], is a lipid mediator that, similar to TGF-[beta], has been showntohavepro-or anti-inflammatory properties under differing circumstances.
