Green adaptations to known asymmetric
aldol additions were investigated by replacing standard organic solvents with acidic, basic, and neutral Hot-Pressurized Water.
On the other side, 2-ethylhexanol is industrially produced through three consecutive reaction processes such as, propylene hydroformylation to n-butyraldehyde, n-butyraldehyde self-condensation, and typical
aldol condensation reaction, which can be catalyzed by an acid, a base, or an acid-base bifunctional catalyst, to give 2-ethyl-2-hexenal, and a hydrogenation, catalyzed by the supported Cu or Ni catalysts, of this last compound to give 2-ethylhexanol [21].
The last method used the classical
aldol reaction to couple acetylferrocene with two different aromatic aldehydes.
In fact, there is a cross-linking reaction and the formation of a Schiff base (imine) by one glutaraldehyde molecule with one amino group, enhancing its
aldol condensation with other glutaraldehyde molecules.
Ramos et al., "Nanosized Ti[O.sub.2]--a promising catalyst for the
aldol condensation of furfural with acetone in biomass upgrading," Catalysis Today, vol.
The
aldol condensation reactions follow the production of pentaerythritose forming the pentaerythritol by reaction kinetics.
(2011) Stereocontrolled total synthesis of (D)-concanamycin F: the strategic use of boron-mediated
aldol reactions of chiral ketones.
Acetone is a backbone intermediate in the production of methyl methacrylate monomers, bisphenol A, and
aldol chemicals such as methyl isobutyl ketone, and is used as a solvent in many of the same products.
2',4'-Dimethoxy-4-hydroxychalcone (4) was synthesized via
aldol condensation by adding thionyl chloride to a mixture of 2',4'-dimethoxyacetophenone and 4-hydroxybenzaldehyde in ethanol at room temperature (Jaypal et al.
reported the application of the chiral ionic liquid 1 and its derivatives as an organocatalyst for
aldol reaction; however, the
aldol products were obtained in moderate yields and selectivities (up to 80% ee) [18].
Among their topics are the inertia of conventional functional groups, the
aldol condensation, macrocycles from reluctant ring closure to reluctant ring opening, transformations mediated by transition metals versus conventional reactions, oxidations and carbon-carbon bond building, and the failure of epoxide ring opening and the limits of cascade reactions.
Papadopoulos, "Green asymmetric synthesis: b-amino alcohol-catalyzed direct asymmetric
aldol reactions in aqueous micelles," Chirality, vol.
