However, the question is why neurostimulation treatment is aimed at increasing cortical excitability (high-frequency rTMS and anodal tDCS) in AD patients who show cortex hyperexcitability.
Indeed, it has been shown that anodal stimulation of the left dorsolateral prefrontal cortex (DLPFC) increases the performance of a sequential-letter working memory task in healthy young adults [18].
However, different methods of noninvasive stimulation, both anodal tDCS and high-frequency rTMS, increase cortical excitability to improve cognitive functioning [7].
For the effective stimulation of tDCS, before this experiment we had already administered both anodal and cathodal stimulation to SMA and M1 of the patient and selected the cathodal stimulation to SMA from the other stimulations.
Patients were randomized to 3 groups, with twenty participants each: Group A, anodal stimulation in ipsilesional M1 and CIMT; Group B, anodal stimulation in ipsilesional PMC and CIMT; Group C, sham stimulation and CIMT.