(NASDAQ: HOOK) is a clinical stage biopharmaceutical company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary
arenavirus platform that is designed to reprogram the body's immune system.
Hookipa Pharma is a clinical stage biopharmaceutical company developing a new class of immunotherapeutics, targeting infectious diseases and cancers based on its proprietary
arenavirus platform that is designed to reprogramme the body's immune system.
(2011) Pathogenesis of
arenavirus hemorrhagic fevers.
A new
arenavirus in a cluster of fatal transplant-associated diseases.
Many viruses have been identified to cause SSHL like CMV, rubella, rubeola, varicella zoster, HSV I, HSV II, parainfluenza A, B, and C, Lassa fever (
Arenavirus), EB virus, HIV with mumps virus accounting for about 7% of adult cases.
[USPRwire, Fri Oct 23 2015] Global Markets Direct's, '
Arenavirus Infection Lassa Fever - Pipeline Review, H2 2015', provides an overview of the
Arenavirus Infection Lassa Fever's therapeutic pipeline.
[1] A small number of nosocomial outbreaks have occurred in SA: Marburg virus disease (MVD) in Johannesburg in 1975, CCHF near Cape Town in 1984, EVD in Johannesburg in 1996, and the Lujo virus, a newly identified
arenavirus, in Johannesburg in 2008 [7-10] (these are dealt with in detail in the 'Clinical Alert' article in this issue of SAMJ [11]).
Examples include the discovery of a novel
arenavirus in liver and kidney transplant tissue (2) and genome reconstruction of an epidemic strain of Shiga toxin-producing Escherichia coli found in stool samples (3).
Viral isolation studies have characterized a divergent
arenavirus associated with the disease that has envelope glycoproteins more similar to those of filoviruses than to those of other arenaviruses.
Examples in which NGS strategies have identified likely causal agents in idiopathic conditions (not all in humans) include Heartland Bunyavirus, titi monkey adenovirus, Bas-Congo virus, Theiler's disease-associated virus, Lujo
arenavirus, and many others.
Aronson, "Genistein treatment of cells inhibits
arenavirus infection," Antiviral Research, vol.
(96) Similarly, Palacios et al (97) used unbiased high-throughput sequencing to identify a previously unknown Old World
arenavirus in specimens collected from 3 recipients of visceral organ transplants from a single donor, who each died of a febrile illness.
Sometimes an
arenavirus, such as the one that causes Lassa hemorrhagic fever, will infect a human.
LCMV is an
arenavirus carried by the common house mouse.
