Later, except with the least potent
fluvastatin, it was identified that statin, in combination with gemfibrosil, produced severe myopathy and rhabdomyolysis.
The data are presented for individual doses of each statin (lovastatin, 10, 20, 40, and 80 mg; pravastatin, 10, 20, and 40 mg; simvastatin, 5, 10, 20, 40, and 80 mg; atorvastatin, 10, 20, 40, and 80 mg;
fluvastatin, 20 and 40 mg; rosuvastatin, 5, 10, 20, and 40 mg; and ezetimibe, 10 mg).
showed that both methotrexate and
fluvastatin are highly effective in lowering proatherogenic cytokines.
The studies which were included in this meta-analysis should meet the following criteria: (1) the design of studies should be controlled strictly, including case-control studies, cohort studies, and RCTs; (2) no prior diagnosis of any cancer prior to the date of cancer diagnosis; (3) studies should specific one or more types of statins, including rosuvastatin, atorvastatin, simvastatin, pravastatin,
fluvastatin, cerivastatin, and lovastatin; (4) studies should be designed to evaluate the impact of statins on the risk of cancers with T2DM; (5) studies should have provided sufficient information to calculate odds ratios (ORs) and 95% confidence intervals (CIs).
In contrast to those lipophilic statins, hydrophilic statins such as pravastatin and
fluvastatin do not deteriorate glycemic control [7,11,14-16] because of the pharmacokinetic differences including hydrophilicity [4,17].
The treatment of mononuclear cells with
fluvastatin produced the discrete activation of caspase 1 and moderated the secretion of IL-1[beta], IL-18, and IFN-[gamma] [67].
Yasue H, Mizuno Y, Harada E et al (2008) Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductaseinhibitor,
fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers.
The hydrophilic statins--pravastatin (Pravacol), rosuvastatin (Crestor) and
fluvastatin (Lescol)--are less likely to affect the muscles than the other four statins.
Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin,
fluvastatin and pravastatin Clin Pharmacokinet 2008; 47(7): 463-74.
The academy also strongly discourages unpasteurized juice products and says grapefruit juice should not be served to children taking certain medications-ibuprofen, flurbiprofen, warfarin, phenytoin,
fluvastatin and amitriptyline-because it interferes with their effects.
Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by
fluvastatin in an in vivo animal model.
The three statins (lovastatin, simvastatin, and atorvastatin) are metabolized by the cytochrome p-450 3A4 (CYP-3A4) isoenzymes, whereas pravastatin is metabolized in the liver by sulfation and
fluvastatin is metabolized by the cytochrome 2C9 isoenzyme (CYP-2C9) [8].
The samples for analysis were fluorinated pharmaceuticals consisting of fluorometholone, flutamide, sodium flurbiprofen (USP-Standard, Rockville, MD, USA), flumazenil, flunitrazepam (Hoffmann-La Roche, Grenzach-Wyhlen, Germany),
fluvastatin sodium hydrate (Hemofarm, Vrsac, Serbia), fluprednidene acetate (Alcon-Pharma, Freiburg, Germany), fluphenazine dihydrochloride (from the former pharmaceutical company Byk-Gulden, Konstanz, Germany), fluoxetine hydrochloride (Teva, Ulm, Germany), fludarabine phosphate (CRS-standard from EDQM, Strasbourg, France), flurazepam hydrochloride (Roche Diagnostics, Mannheim, Germany), flucytosine (Sigma-Aldrich, Taufkirchen, Germany), and fluconazole (Dr.
In serum, pravastatin has been found to have a lower rate of binding with plasma proteins of 43-48% compared to lovastatin, simvastatin, and
fluvastatin which have plasma protein binding rates of at least 95%.
