Miyazawa, "Calculating distortions of short DNA duplexes with base pairing between an oxidatively damaged
guanine and a
guanine," Molecules, vol.
Caption: FIGURE 2: X-ray structures of HD22-27mer (a) and RE31 (b)
guanine quadruplex-containing aptamers bound to thrombin, for ease of differentiating the thrombin binding sites: shown in red ribbon is the light chain of thrombin and shown in grey ribbon is the heavy chain of thrombin with the C-terminal nub of the heavy chain shown in red.
The complete M RNA genome of BA66019 was found to be 5,368 nt long, with a nucleotide composition of 30.9% adenine, 24.7% uracile, 22.1%
guanine, and 22.3% cytocine (G/C content 44.4%).
They form in regions of DNA that are rich in the building block
guanine, usually abbreviated to 'G'.
A compound called cyclic
guanine monophosphate (cyclic GMP) plays a role in regulating circadian rhythm.
In particular, the ith phosphate group can be hydrogenbonded to the exocyclic amino group of the (i + 3)th
guanine base (i.e., [N.sub.2]-[H.sup.B] *** O=P) along the helical strand.
In cell division, each DNA double helix would separate into two strands, and each strand would build up its complementary strand on itself; an adenine fitting over every thymine on the strand, a thymine over every adenine, a
guanine over every cytosine, and a cytosine over every
guanine.
Only four bases (or "letters") combine to form a strand of DNA: adenine (A), thymine (T),
guanine (G), and cytosine (C).
Svetkey and her colleagues found that there is a
guanine (G) to arginine (A) switch at position 6 in the angiotensinogen gene that correlated strongly with pressure response in the DASH cohort.
Kim, "Effects of
guanine bases at the central loop on stabilization of the quadruplex DNAs and their interactions with Meso-tetrakis(N-methylpyridium-4-yl)porphyrin," Biophysical Chemistry, vol.
Utilizing isothermal titration calorimetry, the enthalpy of binding was measured and our results show a large enthalpy change (AH) in the binding of actinomycin D to the two sequences that only differ by the presence of one
guanine. The enthalpy value switches from a favorable value of-3.8 keal/mol for the 5'-TGGGT-3' to an unfavorable value of + 2 keal/mol for the 5'-TGGGT-3'.
To investigate, Levy-Lior and her colleagues extracted
guanine crystals from the skin of the Japanese koi fish and redeye tetra and analyzed them with X-ray diffraction and an electron microscope.
The primer pair Mt-1/A4136G, which includes a single-basepair-mismatched reverse primer (A4136G), and normal template DNA were used to generate the synthetic positive-control PCR product: a 1016-bp product containing a
guanine at nucleotide position 4136.