Fatality after deliberate ingestion of sustained-release
ibuprofen: a case report.
Ibuprofen is established as effective treatment option for acute migraine according to American Academy of Neurology (AAN) and American Headache Society (AHS) Guidelines11, and proved to be better than placebo.12,13 In a recent Cochrane review, NNT for 2-hour pain relief was 7.2 with 400 mg, and 9.7 with 200 mg
ibuprofen.12
Testicular tissues exposed to paracetamol or
ibuprofen in a culture dish had around a quarter fewer sperm-producing cells, the scientists said.
The impact of agitation times of 20 min, 30 min, and 60 min was observed on the preparation of spherical agglomeration of
ibuprofen. (12)
Researchers also measured the quantity of
ibuprofen in the blood in the umbilical cord in order to analyse how much the foetus would have already been exposed to.
Swan explained that "a large body of evidence points to the role of prenatal exposure to environmental factors that alter the in utero hormonal milieu, causing decreased male reproductive health that persists throughout life." However, she said, "this would not likely be an issue for
ibuprofen" because it's not typically recommended for use during pregnancy.
"WITHIN 14 DAYSThe study recruited 31 male volunteers between 18 and 35 years.Of these, 14 were given a daily dosage of
ibuprofen and were given a 1200 mg-per-day dose.
Further analyses revealed that 23.2 percent of
ibuprofen patients who had normal blood pressure at the start of the study developed elevated blood pressure (systolic pressure 130 mmHg or higher and/or diastolic pressure of 80 mmHg or higher), compared with 19 percent of the naproxen users and 10.3 percent of those taking celecoxib (European Heart Journal, online Aug.
"Prescription-strength
ibuprofen is under pressure--it has a high incidence of new-onset hypertension, particularly when compared to the more selective COX-2 inhibitor celecoxib.
BARCELONA -- Prescription-strength
ibuprofen has a bigger adverse effect on blood pressure than celecoxib or naproxen, a finding that suggests a likely mechanism for the worse cardiovascular event rate documented in ibuprofen-treated arthritis patients in the PRECISION trial, Frank Ruschitzka, MD, said at the annual congress of the European Society of Cardiology.
The occurrence of cardiovascular events was 2.3 percent in the celecoxib group, compared to 2.5 percent in the naproxen (Aleve, Anaprox) group and 2.7 percent in the
ibuprofen (Advil, Motrin) group.
Researchers from Cleveland Clinic and Brigham and Women's Hospital, Boston, embarked on a 10-year trial (Prospective Randomized Evaluation of Celecoxib Integrated Safety versus
Ibuprofen or Naproxen, or PRECISION), involving 24,081 patients in 13 countries to investigate the relative cardiovascular safety of celecoxib compared to
ibuprofen and naproxen.
