lysin

The oral presentation, titled 'Exebacase (Lysin CF-301) Improved Clinical Responder Rates In MRSA Bacteremia Including Endocarditis Compared To Standard Of Care Antibiotics Alone In A First-in-Patient Phase 2 Study,' reported data demonstrating clinically meaningful increases in clinical responder rates in the pre-specified MRSA subgroup treated with exebacase, compared to MRSA patients treated with SOC alone, at all timepoints tested, including a 43% higher clinical responder rate at the day 14 primary efficacy timepoint (p=0.010).

NIAID's efforts were initiated by President Obama's National Action Plan for Combating Antibiotic-Resistant Bacteria, which directed governmental agencies to support research into the use of "phage and phage-derived lysins to kill specific bacteria," as well as other nontraditional antibiotics.

Full-length sequence of VERL, the egg vitelline envelope receptor for abalone sperm lysin. Gene 288:111-117.

The VERL-lysin complex structures also suggest how lysin opens a hole into the egg coat, allowing sperm to penetrate into the egg.

Lysin structure reflects this dissimilar biological activity.

Sperm Penetration of Vitelline Envelope of SicyoniaIngentis Eggs is Mediated by a Trypsin like Lysin of Acrosomal Vesicle Origin.

Lysin Motif-Containing Proteins LYP4 and LYP6 Play Dual Roles in Peptidoglycan and Chitin Perception in Rice Innate Immunity.

Scithera Microbial Technologies is engaged in the research and development of lysin solutions for pathogen control in the field of human health.

Lectins have been classified into 12 different families based on their domain structures and phylogenetic analyses: ABA (Agaricus bisporus agglutinin), amaranthin, chitinase-related agglutinin (CRA), cyanovirin, Euonymus europaeus agglutinin (EEA), Galanthus nivalis agglutinin (GNA), hevein, jacalins, legume lectin, lysin motif (LysM), and nictaba and ricin B families (Jiang et al.

CRP--c reactive protein, ASLO--anti streptococcal lysin O

Bacteriophage lysin mediates the binding of Streptococcus mitis to human platelets through interaction with fibrinogen.

While the role of the acrosomal protein M7 lysin on reproductive isolation in Mytilus is well understood, the mechanisms driving the evolution of this protein are not jet fully elucidated (Springer & Crespi, 2007; Hess et al., 2012).

Portnoy, "Listeriolysin O: a phagosome-specific lysin," Microbes and Infection, vol.

Two of the best-characterized gamete recognition systems studied thus far are the sperm-egg binding proteins, bindin and EBR1 (the egg bindin receptor protein-1) in sea urchins, and the lysin and VERL (the egg vitelline envelope receptor for lysin) proteins in abalone and other gastropods (see reviews by Kresge et al., 2001; Swanson and Vacquier, 2002a; Clark et al., 2006; Turner and Hoekstra, 2008; Palumbi, 2009).

There are no known reports of lysin resistance, but "it could happen," says Seal.