KEGG   NETWORK: N01346
Entry
N01346                      Network                                
Name
Nicotine/NNK to cAMP signaling pathway
Definition
(Nicotine,NNK) -> ADRB2 -> GNAS -> ADCY -> cAMP -> PKA
  Expanded
(C00745,C16453) -> 154 -> 2778 -> (107,108,109,196883,111,112,113,114,115) -> C00575 -> (5566+5567+5568)
Class
nt06234 cAMP signaling (cancer)
Type
Env factor
Pathway
hsa05207  Chemical carcinogenesis - receptor activation
Disease
H00014  Non-small cell lung cancer
H00013  Small cell lung cancer
Gene
154  ADRB2; adrenoceptor beta 2
2778  GNAS; GNAS complex locus
107  ADCY1; adenylate cyclase 1
108  ADCY2; adenylate cyclase 2
109  ADCY3; adenylate cyclase 3
196883  ADCY4; adenylate cyclase 4
111  ADCY5; adenylate cyclase 5
112  ADCY6; adenylate cyclase 6
113  ADCY7; adenylate cyclase 7
114  ADCY8; adenylate cyclase 8
115  ADCY9; adenylate cyclase 9
5566  PRKACA; protein kinase cAMP-activated catalytic subunit alpha
5567  PRKACB; protein kinase cAMP-activated catalytic subunit beta
5568  PRKACG; protein kinase cAMP-activated catalytic subunit gamma
Perturbant
C00745 (Nicotine)  Nicotine
C16453 (NNK)  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Metabolite
C00575  3',5'-Cyclic AMP
Reference
PMID:21801603
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:12189387
  Authors
Schuller HM
  Title
Mechanisms of smoking-related lung and pancreatic adenocarcinoma development.
  Journal
Nat Rev Cancer 2:455-63 (2002)
DOI:10.1038/nrc824

  All links  
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical substance (3)   
   KEGG COMPOUND (3)   
Gene (14)   
   KEGG GENES (14)   
Literature (3)   
   PubMed (3)   
All databases (21)   

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