| RLR signaling |
| N00469 |
| | RNA | → | RIGI | → | MAVS | → | TRAF3 | → | (TANK+NAP1+SINTBAD.. | → | (TBK1+IKBKE) | → | (IRF7,IRF3) | ⇒ | (IFNA,IFNB1) |
| N01310 |
| | | | | | | | | | nsp13 | ⊣ | TBK1 |
| N01320 |
| | | | | | | | | | nsp3 | ⊣ | ISG15 | = | IRF3 |
| N01319 |
| | | | | | | | | | | | (nsp6,ORF6) | ⊣ | IRF3 |
| N01308 |
| | RNA | → | (MDA5,ZNFX1) | → | MAVS | → | TRAF3 | → | (TANK+NAP1+SINTBAD.. | → | (TBK1+IKBKE) | → | (IRF7,IRF3) | ⇒ | (IFNA,IFNB1) |
| N01309 |
nsp3 | ⊣ | ISG15 | = | MDA5 |
| | | |
| Complement cascade |
| N01491 |
| | [C4,C2] | − | ((MBL2,COLEC10/11,.. | → | [C4b,C2a] | → | (C4b+C2a) |
| | | D1,D2,D3,D4,D5,D6,D7,D8,D9,D10,D11
| | | |
| N01312 |
| | S | → | (MBL2+MASP1/2) |
| N01487 |
| | [C4,C2] | − | ((C1QA,C1QB,C1QC)+.. | → | [C4b,C2a] | → | (C4b+C2a) |
| D1,D2,D3,D4,D5,D6,D7,D8,D9,D10,D11
| | | | | |
| N01314 |
S | → | (IgG,IgM) | → | ((C1QA,C1QB,C1QC)+.. |
| N01315 |
| | F2 | − | ((MBL2,COLEC10/11,.. | → | F2a |
| N01502 |
| | | | FG | − | (F2a,((MBL2,COLEC1.. | → | Fibrin |
| | | D1,D2,D3,D4,D5,D6,D7,D8,D9,D10,D11
| | | |
| N01316 |
| | (S,N) | → | (MBL2,COLEC10/11,F.. |
| | | |
| IFN signaling |
| N00150 |
(IFNA,IFNB1) | → | (IFNAR1+IFNAR2) | → | (JAK1,TYK2) | → | (STAT1+STAT2+IRF9) | ⇒ | (IRF7,EIF2AK2) |
| N01321 |
| | | | (nsp1,nsp6,nsp13,O.. | ⊣ | STAT1 |
| N01322 |
| | | | (nsp6,nsp13,ORF7a,.. | ⊣ | STAT2 |
| | | |
| Translation |
| N01317 |
| | 40S | = | mRNA | = | 60S |
| N01318 |
nsp1 | ⊣ | 40S |
| | | |
| Angiotensin II signaling |
| N01306 |
| | | | AngII | → | AGTR1 | → | NOX2 | → | ROS | → | NFKB | → | (VCAM1,IL6,MMP2,MM.. |
| D1,D2,D3,D4,D5,D6,D7,D8,D9,D10,D11
| | | | | | | | | | | | | | | |
| N01307 |
S | ⊣ | ACE2 | ⊣ | AngII | → | AGTR1 | → | NOX2 | → | ROS | → | NFKB | → | (TNF,IL6,IL1B,IL12.. |
|
Network variation - SARS coronavirus 2 (SARS-CoV-2)