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Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.

Chronicles ordinary people getting caught up in extraordinary situations, where one wrong turn leads to another, until it's too late to turn back.

Shaun Murphy, a young surgeon with autism and Savant syndrome, is recruited into the surgical unit of a prestigious hospital.

Two detectives with different views on the world team up and using cynicism, guile and deception, they clean up the streets of Battle Creek.

At the turn of the 20th century the Metropolitan Police were overwhelmed with bizarre cases so they turned to outsiders including Houdini and Doyle, who collaborated with New Scotland Yard on some unsolved and inexplicable crimes.

In a traditionally male-dominated world, one female police officer (Janssen) finds her place at the center of this new drama.

House treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.

A very brave and mature 9-year-old girl has terminal cancer, but that is not what the problem seems to be.

While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.

Can House save a high powered female executive from the same problem that has left him in constant pain? A new head of the hospital board could cause problems. Clinic cases: A boy and his mute dad.

A young boy's fever lasts nearly a week after a Ouija board predicts he will die. Clinic Cases: Chase's case of a man with numb fingers.

A famous jazz trumpeter, diagnosed with ALS, signs a DNR form, but because House believes the diagnosis wrong, he breaks the law by resuscitating him.

The team takes care of a student with inexplicable electrical shocks, and House's parents visit.

A nun suffering from acute dermatitis and asthma treated by House with possibly the wrong medication comes dangerously close to death.

A woman collapses at an off-track betting parlor in front of House, and he must battle his new boss to find her diagnosis.

A girl crashes a Porsche after her boyfriend starts coughing up blood and continues to have unexplained bleeds. Clinic Cases: Cuddy gives House a month off clinic duties if he can spend a week off his pain meds.

When a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.

A woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.

A patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.

A morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Clinic Patients: Unidentified man with an infected pierced scrotum; overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.

A delusional homeless woman is found unconscious in an acid house exhibiting a variety of symptoms which Foreman thinks she's faking.

Cuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."

After being accused of assaulting a sick man, House is forced to take on his case. However, despite the fact that he has AIDS, it's clearly not what's killing him.