For starters, we have 3 autistic characters who are trying to become independent. I love that all 3 of them have different personalities when usually on shows with autistic characters autism is portrayed as a personality.
Each character has very different struggles which are also realistic. Violet wants to get a boyfriend for some resemblance of "normality". Jack is dealing with his dad's illness and feeling the pressure of having to stand on his own, with no support system. Harrison struggles to get out of the house because of several hypersensitivities.
In between all of this, their families struggle with a balance between wanting them to change and accepting them as they are. Sad but also quite realistic. They struggle with starting and maintaining relationships. They struggle with getting and keeping a job. These are things most autistics can identify with.
I would have liked the show to focus more on mental health which is pretty much absent for the whole season. Mandy is not a psychologist and I find it hard to believe these characters would have families that support them but no mental health services.