Charlene deGuzman, John Hawkes and Melissa Leo are all brilliant in this film. Sex and love can be the worst of all addictions, because it is free and easily attainable, and most don't understand what a nightmare it can be for the person. Charlene's Joy captured that, and her performance will surely resonate with those who suffer. There is something light and charming about her, that makes you root for her, despite how little she loves herself. John Hawkes is subtle and perfect, as a shy, peculiar man who is unable to even make eye contact, yet has more attachment skills than Joy. Melissa Leo is brittle yet compassionate. Ellen Geer, who plays the grandmother, was spot-on as a woman with Alzheimer's. It was quite a movie, and I'm so glad I saw it.