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- DirectorJennifer GetzingerStarsMichael SheenLizzy CaplanCaitlin FitzGeraldVirginia and Dr. Masters move on to filming involuntary reactions during the study, with Jane as usual being the first subject. Ethan reveals information about his heritage that threatens their relationship.
- DirectorLesli Linka GlatterStarsMichael SheenLizzy CaplanCaitlin FitzGeraldA former study participant comes forward with news of her pregnancy. Ethan learns he has been effectively fired, but not for the reason he thought.
- DirectorPhil AbrahamStarsMichael SheenLizzy CaplanCaitlin FitzGeraldMasters and Libby compile study information for hospital-wide presentation; DePaul and Johnson travel to a medical convention; Virginia's ex returns finds Ethan playing father to his children.
- DirectorMichael DinnerStarsMichael SheenLizzy CaplanCaitlin FitzGeraldDr. Masters' big day is at hand after 12 months of studies. Without Virginia as a voice of moderation will Bill's pitch hit the mark? Margaret Scully is confronted with her husband's homosexuality and investigates what is involved with his 'treatment'.
- DirectorMichael AptedStarsMichael SheenLizzy CaplanCaitlin FitzGeraldVirginia breaks the news to Ethan and Bill tries to be there for Libby and their new baby but finds it hard. Bill is struggling with getting his career back on track and Virginia is still working for Dr. DePaul but hungers for more. Scully is determined to succeed in his "therapy", but Margaret will bear no more illusions in her life.
- DirectorMichael AptedStarsMichael SheenLizzy CaplanCaitlin FitzGeraldMasters begins a new job at Memorial Hospital - under Betty's terms - only to find his boss insisting he leave Virginia behind in favor of a handpicked secretary. Johnson, meanwhile, still alienated at Maternity, is torn between pressing Masters to rehire her and staying by DePaul's side as her condition worsens.
- CreatorMichelle AshfordStarsMichael SheenLizzy CaplanCaitlin FitzGeraldDrama about the pioneers of the science of human sexuality whose research touched off the sexual revolution.
- DirectorMichael AptedStarsMichael SheenLizzy CaplanCaitlin FitzGeraldVirginia unearths Masters' troubled childhood during a secret rendezvous.
- DirectorMichael EnglerStarsMichael SheenLizzy CaplanCaitlin FitzGeraldJohnson tries to cover when she and Masters are seen by Langham leaving a hotel together after an evening tryst. Later, Masters attempts to bring Johnson aboard as his assistant at his new post; and Betty tries to conceal her infertility from Gene, over Masters' objections.
- DirectorEdward OrnelasStarsMike VogelRachelle LefevreAlexander KochJulia takes over as leader of Chester's Mill after the town becomes divided in the wake of Big Jim and Rebecca's plans for population control. Meanwhile, Joe and Norrie continue to help Melanie search for more clues about her identity.
- DirectorNeil JordanStarsJeremy IronsFrançois ArnaudHolliday GraingerExtremely ruthless and ambitious cardinal Rodrigo Borgia uses bribery to take advantage of the death of the current Pope and rise to the Papacy.
- DirectorNeil JordanStarsJeremy IronsFrançois ArnaudHolliday GraingerMicheletto, Orsini's assassin is recruited by Cesare to defect into the service of Della Rovere who is trying to prove Rodrigo has taken on a mistress.
- DirectorSimon Cellan JonesStarsJeremy IronsFrançois ArnaudHolliday GraingerSultan Cem of the Ottoman Empire arrives at Rome. Cesare declines his brothers request of using Michelotto. The Pope tries to decide who is to marry his daughter.
- DirectorSimon Cellan JonesStarsJeremy IronsFrançois ArnaudHolliday GraingerRodrigo's children insist that their mother be invited to Lucrezia's arranged political marriage to a Sforza, but the Pope resists.
- DirectorJohn MayburyStarsJeremy IronsFrançois ArnaudHolliday GraingerCesare Borgia takes the beautiful Ursula Bornadeo as his mistress and vows to revenge himself on her husband who has insulted his mother.
- DirectorJohn MayburyStarsJeremy IronsFrançois ArnaudHolliday GraingerIn order to ensure a lasting alliance with Naples, the Pope betroths his 13 year old son to his bastard daughter while Della Rovere conspires in France.
- DirectorJeremy PodeswaStarsJeremy IronsFrançois ArnaudHolliday GraingerDella Rovere convinces the French king to invade Milan and is aghast at the slaughter while Cesare discovers the abbey where Ursula has retreated after her husband's death.
- DirectorJeremy PodeswaStarsJeremy IronsFrançois ArnaudHolliday GraingerPaolo helps Lucrezia and Guilia escape Sforza, but they are captured by advancing French forces as the Pope's cardinals flee Rome before King Charles' military juggernaut.
- DirectorJeremy PodeswaStarsJeremy IronsFrançois ArnaudHolliday GraingerThe Pope disarms King Charles by promising his support for his Neapolitan claims, and wishes to annul Lucrezia's marriage on grounds of her husband's impotency.
- DirectorNeil JordanStarsJeremy IronsFrançois ArnaudHolliday GraingerThe King of France revenges himself on King Alfonso of Naples for the plague, and after finding pornographic frescoes the Pope decides to revive Roman bacchanalia.
- DirectorNeil JordanStarsJeremy IronsFrançois ArnaudHolliday GraingerPaolo searches for Lucrezia and their son, and the Pope inspects the lives of commoners with Vittoria and Guilia in disguise.
- DirectorJon AmielStarsJeremy IronsFrançois ArnaudHolliday GraingerLucrezia is inconsolable after Paolo's death, but it is ruled a suicide as King Charles marches north to revenge themselves on the Pope and the Eternal City.
- DirectorJon AmielStarsJeremy IronsFrançois ArnaudHolliday GraingerCesare learns that Ursula and others at the convent have been slaughtered by the French, and he plans revenge as the Pope organizes a coalition to attack the retreating French.
- DirectorKari SkoglandStarsJeremy IronsFrançois ArnaudHolliday GraingerCesare goes to Forli to convince Catherina Sforza to pledge allegiance to the Pope while the Pontiff tries to find a way to buy off Cardinal Savarona.
- DirectorJohn MayburyStarsJeremy IronsFrançois ArnaudHolliday GraingerMachiavelli gives Cesare information on De Medici gold, and Rodrigo pressures Lucrezia into another political marriage.