- Is the only actor to appear in 14 different seasons of "Star Trek," more than any other actor (Star Trek: The Next Generation (1987), seasons 1 through 7, and Star Trek: Deep Space Nine (1993), seasons 1 through 7).
- Meaney and Star Trek wife Rosalind Chao remained good friends after Star Trek: Deep Space Nine (1993) ended. Chao attended Meaney's 2007 wedding to his second (real-life) wife Ines Glorian.
- Along with Jonathan Frakes, Marina Sirtis, Michael Dorn, he is one of only four actors to appear in the finales of two different "Star Trek" series: Star Trek: The Next Generation (1987) and Star Trek: Deep Space Nine (1993).
- His role and rank in the Star Trek series took several years to evolve. Beginning as a crewman in Star Trek: The Next Generation (1987) the character of Miles O'Brien then graduated to the transporter room and was briefly a lieutenant before being made a chief petty officer, thus joining one of the very few recurring enlisted roles in Star Trek (Mr Leslie and Yeoman Rand being two others from the original series). Transferring to Star Trek: Deep Space Nine (1993), the O'Brien character mutated the first two seasons between a warrant officer and an chief warrant officer before again becoming enlisted as a senior chief petty officer around the fourth season. In the last seasons of Star Trek: Deep Space Nine (1993), the rank of senior chief was once and for all confirmed and O'Brien became the first-ever Star Trek enlisted character to be given an enlisted rank insignia collar pin.
- Was offered the chance to direct an episode of Star Trek: Deep Space Nine like his DS9 co stars Avery Brooks, Rene Auberjonois, Alexander Siddig, Michael Dorn and Andrew Robinson, but declined.
- Acted in the Focus Company in Dublin with Gabriel Byrne and Stephen Rea in the late 1970s.
- Despite having different names in each movie, he played the same character in The Commitments (1991), The Snapper (1993) and The Van (1996).
- Was a background character on Star Trek: The Next Generation (1987)'s pilot episode, Encounter at Farpoint (1987). He had a semi-recurring role as "Battle Bridge Conn." His character was eventually given a name and rank (transporter chief Miles Edward O'Brien). He was made the engineer of DS9 on Star Trek: Deep Space Nine (1993) in 1993.
- Meaney has appeared in 3 different movies in which hijackings were major plot components: Die Hard 2 (1990), Under Siege (1992), and Con Air (1997).
- Both he and his Star Trek: Deep Space Nine (1993) co-star Rene Auberjonois, appeared in "Stargate" series, each playing the leader of a human civilization on another planet whose population lived under the surface. In both cases, the main characters of the series in question attempted to form an alliance and arrange an exchange of technology before learning that this civilization could not be trusted. Meaney played Cowen, leader of the Genii in three episodes of Stargate: Atlantis (2004); Auberjonois played Alar, leader of the Eurondans, in one episode of Stargate SG-1 (1997).
- Meaney himself has stated that he thoroughly disliked Up the Long Ladder (1989)(#2.18) for its depiction of a group of Irish colonists as little more than backwards, drunken farmers. Critics and fans have commented that Meaney's discomfort during the episode was quite visible.
- Played the same character, Chief Miles Edward O'Brien, on Star Trek: The Next Generation (1987) and Star Trek: Deep Space Nine (1993) for twelve consecutive years from 1987 to 1999. The only other "Star Trek" actor to do this is Michael Dorn.
- Along with Patrick Stewart and Armin Shimerman, he is one of only three actors to appear in the pilots of two different "Star Trek" series: Star Trek: The Next Generation (1987) and Star Trek: Deep Space Nine (1993) for Patrick and Colm. Armin appeared in Star Trek: Deep Space Nine (1993) and Star Trek: Voyager (1995).
- In 2007 he was nominated for a Olivier award for Best performance in a supporting role for his role in " A Moon for the Misbegotten " at the Old Vic.
- Daughter Ada born in 2004.
- Also has a daughter named Brenda.
- Currently starring alongside Kevin Spacey in "Eugene O'Neill''s "A Moon for the Misbegotten" at the Old Vic Theatre in London, UK. (October 2006)
- Former son-in-law of Irish-American actor Vincent Dowling and Brenda Doyle.
- One of only three actors to appear in over 200 episodes of Star Trek, the others being Patrick Stewart and Michael Dorn.
- Shares a birthday anniversary (month and day only) with fellow Star Trek actor Mark Sheppard.
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