- Her father, Jim O'Brien, was a well known and respected radio and TV News weatherman/personality in Philadelphia in the '70s and early 80s. He died in a skydiving accident on September 25, 1983.
- Worked as a makeup artist before getting her acting break after meeting Blythe Danner, who became her main supporter.
- Actually worked as a radio show sound engineer.
- Was the only one of the five main cast members for Frasier (1993) never to be nominated for an Emmy.
- Godmother to Frasier (1993) co-star Jane Leeves's daughter, Isabella Kathryn Coben.
- Owns a production company, "Bristol Cities", with Frasier (1993) co-star Jane Leeves and Jane's sister, Kathryn.
- Her parents named her after the titular squirrel from Walt Disney Pictures' live action feature Perri (1957).
- After years of failed in vitro treatments, she and her husband turned to surrogacy. Twin daughters, Stella and Ava finally arrived in a Nevada hospital on May 7, 2004. The couple burbled that holding their new girls was "the best, best in the world, world."
- Graduated from Skyline High School, Dallas, Texas.
- Older sister of actors Marc Gilpin and April Gilpin.
- Her husband, Vincent, is an artist.
- Weighed so much during gestation that her parents thought she was a boy.
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