- His parents own and live in a bed & breakfast establishment in London across the street from the Sherlock Holmes Museum.
- Plays piano and guitar to performance level
- Graduated from the London Academy of Music & Dramatic Arts in 1996.
- He is of Polish Jewish and Russian Jewish descent.
- James studied for a BA in English and Related Literature at the University of York, where he was a member of Derwent college. He graduated in 1993.
- His wife, Neha, is from India.
- Two sons and a daughter with wife, Neha Callis: Joshua Amaan Callis (born 2003) and Sacha Callis (born 2005). Anika Jahan Callis (born 2009).
- He was awarded the 1996 Jack Tinker Award (Theatre Record Critic of the Year) for Most Promising Newcomer for his performance in Old Wicked Songs.
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