- Auditioned for the House role on House (2004).
- Ridiculed the Bravo interview series, Inside the Actors Studio (1994), in both his stand-up comedy and on Mr. Show with Bob and David (1995). He later acted alongside its host, James Lipton, in several episodes of Arrested Development (2003) where, despite some initial awkwardness, the two got along well with Cross praising Lipton's comedic performance while maintaining that he "didn't care for" Lipton's interview series.
- Is best friends with H. Jon Benjamin.
- Has a daughter with wife Amber Tamblyn, Marlow Alice Cross (b. February 2017).
- In long-term relationship with Amber Tamblyn (2009).
- Attended Emerson College in Boston.
- His British father and American mother divorced when he was very young.
- Engaged to Amber Tamblyn [August 17, 2011]. They have been together since 2009.
- Cross is 19 years older than his wife, Amber Tamblyn.
- Once lived with Greg Behrendt. Both comedians have at one point told jokes involving their former landlord, Shumul.
- His father was originally from England. David's family is Jewish.
- The Rock Against Bush Vol. 1 bonus DVD includes footage of his standup comedy.
- Son-in-law of Russ Tamblyn and Bonnie Tamblyn.
- Brother of Juli Cross and Wendy Cross.
- Stand-up comedian and actor.
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