Drena De Niro, Lady Gaga, and Leandro De Niro Rodriguez in A Star Is Born (2018)

Rene Russo, William Shatner, and Drena De Niro in Showtime (2002)

Rene Russo and Drena De Niro in Showtime (2002)

Robert De Niro, Eddie Murphy, Rene Russo, William Shatner, and Drena De Niro in Showtime (2002)

Robert De Niro, Drena De Niro, and Leandro De Niro Rodriguez

Drena De Niro and Melissa Rivers in Joy (2015)

Debi Mazar, Rosie Perez, and Drena De Niro at an event for Entourage (2004)

Drena De Niro at an event for Entourage (2004)

Jaid Barrymore, Drena De Niro, and Victoria Gotti at an event for Entourage (2004)

Drena De Niro at an event for Showtime (2002)

Robert De Niro, Rene Russo, and Drena De Niro at an event for Showtime (2002)

Drena De Niro, Michael Imperioli, and John Ventimiglia in On the Run (1999)