- Daughter of actors Diahnne Abbott and Robert De Niro. Robert adopted her when he married her mother.
- She is proficient in martial arts, muay thai and yoga.
- She was named after a river called Drina that is featured in the book "The Bridge on the Drina" by a Nobel-winning writer Ivo Andric.
- Siblings are Raphael De Niro, Aaron Kendrick De Niro, Julian Henry De Niro and Elliott De Niro.
- Worked as a dee-jay, a model, and a fashion consultant before turning to acting.
- Has a son, Leandro (b.2003).
- Drena is an accomplished equestrian, and will take the opportunity to go horseback riding any chance she can get.
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