- Didn't like being called Chris as a kid, so he changed his name to Topher by dropping Chris from Christopher for show business.
- Wore a wig on That '70s Show (1998) to make his haircut look more in line with the men's hairstyles of the 1970s. This is why during the first season his hair changes color from brown to light red in some episodes.
- To prepare for his role as Venom in Spider-Man 3 (2007), he worked out for six months, gaining 24 pounds of muscle. He based his performance on alcoholics and drug addicts.
- While in the Venom costume he used in Spider-Man 3 (2007), he didn't drink any water during his breaks because he couldn't use the bathroom with his costume on.
- Decided not to come back for the last season of That '70s Show (1998) and, instead, bought an apartment in New York to be closer to his family and focus on his film career. [2005].
- Attended summer camp with Chloë Sevigny, they appeared in several stage plays together. Though only a few years older, Chloë used to babysit he and his younger sister.
- He has made his own fan edits of several popular films. In 2012 he edited the three Star Wars "Prequel Trilogy" films into a single 85 minute film, and in 2019 edited a five minute trailer with every live-action Star Wars film. He also edited the Hobbit films into a single two hour film.
- His acting mentors were Kurtwood Smith and Debra Jo Rupp, who played his character's parents on That '70s Show (1998).
- His favorite performances are James Stewart in It's a Wonderful Life (1946) and Bill Murray in Groundhog Day (1993).
- (January 5, 2020) His wife, Ashley Hinshaw, is expecting their second child.
- Recommended ex-girlfriend Ginnifer Goodwin for the role of Cathy Feely in Win a Date with Tad Hamilton! (2004).
- Enjoys playing tennis and even considered doing it professionally. He also enjoys soccer.
- Godfather of Kyle Newman & Jaime King's son James.
- Attended USC.
- Corey Howard (Glenn Howerton), the central character of the failed That '80s Show (2002), was the cousin of Topher's character, Eric Forman, from That '70s Show (1998).
- Heroes are Chris Farley and David Spade.
- Entertainment Weekly once predicted that he would be the next Tom Hanks.
- As of 2019, Grace has appeared in two films nominated for Best Picture, Traffic (2000) and BlacKkKlansman (2018).
- Father, with Ashley Hinshaw, of daughter Mabel Jane Grace (b. November 1, 2017).
- Dislikes the movie Space Jam (1996). He once worked in a video shop that played it constantly.
- The directors he wants to work with the most are P.J. Hogan, Peter Sollett, Robert Zemeckis, James Cameron, Sofia Coppola, Steven Spielberg, Clint Eastwood, and Guillermo del Toro.
- Second cousin, twice removed, of H&R Block founders, brothers Henry W. Bloch and Richard Bloch. Jonas Wollman and Betty Kohn, who were Topher's three times paternal great-grandparents, were also the Bloch brothers' maternal great-grandparents.
- He and his fellow cast mates from That '70s Show (1998), Laura Prepon (Donna) and Danny Masterson (Hyde), have all made guest appearances on King of the Hill (1997), but not in the same episode.
- Performed the lead role of Pseudolus, the comical narrator, in "A Funny Thing Happened On The Way To The Forum" at his high school. He also appeared in "Fiddler On The Roof," "Joseph And The Amazing Technicolor Dreamcoat" and "The Pirates Of Penzance".
- Topher's great-great-great-aunt was Kate Wollman, who donated the funds to build New York's famous Wollman Rink, a public ice rink which opened in 1949. Kate was the sister of Topher's paternal great-great-grandmother Rosa Wollman.
- Often seen wearing a watch on his right wrist, but appears to be ambidextrous.
- Won the 2005 New Power Award for In Good Company (2004) and P.S. (2004).
- Topher's paternal grandfather, Walter Kenneth Grace, was from Oklahoma. Topher's paternal grandmother, Muriel Cecile Hess, who was from New York City, was from an upper-class German Jewish family. Topher's mother is of Irish heritage.
- Attended the Brewster Academy, Wolfeboro, New Hampshire; boarding school University of Southern California for one year.
- Mother, Pat, works as a receptionist at the New Canaan Country School in New Canaan, Connecticut.
- New York City: Starring in the off-broadway play "Lonely, I'm Not" until June 5th. (May 2012)
- Shares the exact birth date and birth year (July 12, 1978) with actress Michelle Rodriguez.
- Contributed to and supports Barack Obama for the 2008 presidential campaign.
- Childhood friend of Dave Karger.
- Nephew of Susan Grace.
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