- Roomed with Jay Leno when both were fledgling entertainers, during which time Prinze learned how to drive a car under Leno's tutelage. According to Leno, when Freddie eventually landed the title role in Chico and the Man (1974), he was earning $750 per week.
- Explained how he got his professional last name by saying, "Bob Hope is the king of comedy. Everyone knows that. I'd just be content with being the prince." He later altered prince to Prinze.
- Was pulled over by police on a highway on November 16, 1976, for DUI (driving under the influence). At the time, he was under the influence of methaqualone, a prescription drug that was prescribed by his psychiatrist.
- He was posthumously awarded a Star on the Hollywood Walk of Fame for Television at 6755 Hollywood Boulevard in Hollywood, California, on December 14, 2004.
- During his lifetime, he described his ethnic heritage as 'Hunga-rican' (Hungarian and Puerto Rican). While his mother was of Puerto Rican ancestry, his father, Edward Karl Pruetzel, was German, not Hungarian, having been born in Berlin, Germany, in 1914, to Friedrich Karl Prutzel and Eleonare Maria Schultes. Edward moved to the United States in 1934. Prinze's son, Freddie Prinze Jr., has stated that his father was of half German and half Puerto Rican ancestry.
- He appeared on the show Jack Paar Tonite (1973) with Charlton Heston, who said that he hoped one day he would able to say he was on the first show on which Freddie Prinze performed.
- According to fellow comic Jimmie 'JJ' Walker, Prinze was so furious when John Travolta made a cover of a magazine instead of him that he appeared at Travolta's front door with a loaded pistol. Travolta, who was a growing sex symbol due to his stardom on Welcome Back, Kotter (1975) at the time, was not at home.
- Once had a relationship with Raquel Welch.
- Once had a relationship with actress Pam Grier.
- Dropped out of the Fiorello LaGuardia High School of the Performing Arts to pursue his comedy career.
- Following his untimely death, he was interred at Forest Lawn Memorial Park (Hollywood Hills) in Los Angeles, California, in the Court of Remembrance. He was buried near tough guy actor George Raft.
- His last public performance was less than a week before his untimely death, at the Jimmy Carter Inaugural Gala in Washington, D.C.
- Friends with Alan Bursky and Tony Orlando.
- Freddie Prinze was classmates and childhood friends with tough guy actor Vic Noto.
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