- Was high school prom king.
- Set a record on Celebrity Jeopardy! for most money earned at $29,400 ($24,400 + $5000 victory bonus). (1999)
- While attending Columbia College in Chicago, Andy had the title role in a class film called "My Dinner with Andy", a parody of the film My Dinner with Andre (1981).
- His last name means "judge" in German. Andy's paternal grandmother was of French descent. Andy's maternal grandmother was born in Lahowkow, China, to Swedish parents. His other ancestry is German, English, and remote Welsh.
- His father is an expert in Russian linguistics.
- Attended the University of Illinois at Urbana-Champaign.
- In September 1999, he announced his retirement from Late Night with Conan O'Brien (1993) nine months hence (mid-May 2000).
- Son, William Oscar, born 2001.
- Attended Yorkville High School in Yorkville, Illinois.
- Daughter, Mercy Josephine, was born March 2007.
- Brother-in-law of Becky Thyre.
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